The effect of free glutamine and peptide ingestion on the rate of muscle glycogen resynthesis in man

Gerrit Van Hall; W H Saris; P A van de Schoor; A J Wagenmakers

The effect of free glutamine and peptide ingestion on the rate of muscle glycogen resynthesis in man

Gerrit Van Hall, W H Saris, P A van de Schoor, A J Wagenmakers

Exercise and Muscle

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

36 Citationer (Scopus)

Abstract

Udgivelsesdato: 2000-Jan

Originalsprog	Engelsk
Tidsskrift	International Journal of Sports Medicine
Vol/bind	21
Udgave nummer	1
Sider (fra-til)	25-30
Antal sider	5
ISSN	0172-4622
Status	Udgivet - 2000

Bibliografisk note

Keywords: Administration, Oral; Adult; Dietary Carbohydrates; Dietary Supplements; Exercise; Glutamine; Glycogen; Humans; Male; Muscle, Skeletal; Peptides; Physical Endurance

Citationsformater

@article{accf3e704f7311de87b8000ea68e967b,

title = "The effect of free glutamine and peptide ingestion on the rate of muscle glycogen resynthesis in man",

abstract = "The present study investigated previous claims that ingestion of glutamine and of protein-carbohydrate mixtures may increase the rate of glycogen resynthesis following intense exercise. Eight trained subjects were studied during 3 h of recovery while consuming one of four drinks in random order. Drinks were ingested in three 500 ml boluses, immediately after exercise and then after 1 and 2 h of recovery. Each bolus of the control drink contained 0.8 g x kg(-1) body weight of glucose. The other drinks contained the same amount of glucose and 0.3 g x kg(-1) body weight of 1) glutamine, 2) a wheat hydrolysate (26% glutamine) and 3) a whey hydrolysate (6.6% glutamine). Plasma glutamine, decreased by approximately 20% during recovery with ingestion of the control drink, no changes with ingestion of the protein hydrolysates drinks, and a 2-fold increase with ingestion of the free glutamine drinks. The rate of glycogen resynthesis was not significantly different in the four tests: 28 +/- 5, 26 +/- 6, 33 +/- 4, and 34 +/- 3 mmol glucosyl units x kg(-1) dry weight muscle x h(-1) for the control, glutamine, wheat- and whey hydrolysate ingestion, respectively. It is concluded that ingestion of a glutamine/carbohydrate mixture does not increase the rate of glycogen resynthesis in muscle. Glycogen resynthesis rates were higher, although not statistically significant, after ingestion of the drink containing the wheat (21 +/- 8%) and whey protein hydrolysate (20 +/- 6%) compared to ingestion of the control and free glutamine drinks, implying that further research is needed on the potential protein effect.",

author = "{Van Hall}, Gerrit and Saris, {W H} and {van de Schoor}, {P A} and Wagenmakers, {A J}",

note = "Keywords: Administration, Oral; Adult; Dietary Carbohydrates; Dietary Supplements; Exercise; Glutamine; Glycogen; Humans; Male; Muscle, Skeletal; Peptides; Physical Endurance",

year = "2000",

language = "English",

volume = "21",

pages = "25--30",

journal = "International Journal of Sports Medicine",

issn = "0172-4622",

publisher = "GeorgThieme Verlag",

number = "1",

}

TY - JOUR

T1 - The effect of free glutamine and peptide ingestion on the rate of muscle glycogen resynthesis in man

AU - Van Hall, Gerrit

AU - Saris, W H

AU - van de Schoor, P A

AU - Wagenmakers, A J

N1 - Keywords: Administration, Oral; Adult; Dietary Carbohydrates; Dietary Supplements; Exercise; Glutamine; Glycogen; Humans; Male; Muscle, Skeletal; Peptides; Physical Endurance

PY - 2000

Y1 - 2000

N2 - The present study investigated previous claims that ingestion of glutamine and of protein-carbohydrate mixtures may increase the rate of glycogen resynthesis following intense exercise. Eight trained subjects were studied during 3 h of recovery while consuming one of four drinks in random order. Drinks were ingested in three 500 ml boluses, immediately after exercise and then after 1 and 2 h of recovery. Each bolus of the control drink contained 0.8 g x kg(-1) body weight of glucose. The other drinks contained the same amount of glucose and 0.3 g x kg(-1) body weight of 1) glutamine, 2) a wheat hydrolysate (26% glutamine) and 3) a whey hydrolysate (6.6% glutamine). Plasma glutamine, decreased by approximately 20% during recovery with ingestion of the control drink, no changes with ingestion of the protein hydrolysates drinks, and a 2-fold increase with ingestion of the free glutamine drinks. The rate of glycogen resynthesis was not significantly different in the four tests: 28 +/- 5, 26 +/- 6, 33 +/- 4, and 34 +/- 3 mmol glucosyl units x kg(-1) dry weight muscle x h(-1) for the control, glutamine, wheat- and whey hydrolysate ingestion, respectively. It is concluded that ingestion of a glutamine/carbohydrate mixture does not increase the rate of glycogen resynthesis in muscle. Glycogen resynthesis rates were higher, although not statistically significant, after ingestion of the drink containing the wheat (21 +/- 8%) and whey protein hydrolysate (20 +/- 6%) compared to ingestion of the control and free glutamine drinks, implying that further research is needed on the potential protein effect.

AB - The present study investigated previous claims that ingestion of glutamine and of protein-carbohydrate mixtures may increase the rate of glycogen resynthesis following intense exercise. Eight trained subjects were studied during 3 h of recovery while consuming one of four drinks in random order. Drinks were ingested in three 500 ml boluses, immediately after exercise and then after 1 and 2 h of recovery. Each bolus of the control drink contained 0.8 g x kg(-1) body weight of glucose. The other drinks contained the same amount of glucose and 0.3 g x kg(-1) body weight of 1) glutamine, 2) a wheat hydrolysate (26% glutamine) and 3) a whey hydrolysate (6.6% glutamine). Plasma glutamine, decreased by approximately 20% during recovery with ingestion of the control drink, no changes with ingestion of the protein hydrolysates drinks, and a 2-fold increase with ingestion of the free glutamine drinks. The rate of glycogen resynthesis was not significantly different in the four tests: 28 +/- 5, 26 +/- 6, 33 +/- 4, and 34 +/- 3 mmol glucosyl units x kg(-1) dry weight muscle x h(-1) for the control, glutamine, wheat- and whey hydrolysate ingestion, respectively. It is concluded that ingestion of a glutamine/carbohydrate mixture does not increase the rate of glycogen resynthesis in muscle. Glycogen resynthesis rates were higher, although not statistically significant, after ingestion of the drink containing the wheat (21 +/- 8%) and whey protein hydrolysate (20 +/- 6%) compared to ingestion of the control and free glutamine drinks, implying that further research is needed on the potential protein effect.

M3 - Journal article

C2 - 10683095

SN - 0172-4622

VL - 21

SP - 25

EP - 30

JO - International Journal of Sports Medicine

JF - International Journal of Sports Medicine

IS - 1

ER -