The effect of in vivo growth hormone treatment on blood gene expression in adults with growth hormone deficiency reveals potential biomarkers to monitor growth hormone therapy

L Fernández-Pérez; J Nóvoa; N Ståhlberg; R Santana-Farré; M Boronat; D Marrero; L Henríquez-Hernández; G Norstedt; Amilcar Flores Morales

doi:10.1111/j.1365-2265.2009.03732.x

The effect of in vivo growth hormone treatment on blood gene expression in adults with growth hormone deficiency reveals potential biomarkers to monitor growth hormone therapy

L Fernández-Pérez, J Nóvoa, N Ståhlberg, R Santana-Farré, M Boronat, D Marrero, L Henríquez-Hernández, G Norstedt, Amilcar Flores Morales

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

13 Citationer (Scopus)

Abstract

Growth hormone (GH) replacement therapy is presently utilized in the treatment of adult GH deficiency (AGHD). Adult responses to GH treatment are highly variable and, apart from measurement of IGF-I, few tools are currently available for monitoring GH treatment progress. As GH receptors are expressed in certain blood cell types, changes in gene expression in peripheral blood can reflect perturbations induced as a result of GH therapy.

Originalsprog	Engelsk
Tidsskrift	Clinical Endocrinology
Vol/bind	72
Udgave nummer	6
Sider (fra-til)	800-6
Antal sider	7
DOI	https://doi.org/10.1111/j.1365-2265.2009.03732.x
Status	Udgivet - 2010
Udgivet eksternt	Ja

Adgang til dokumentet

10.1111/j.1365-2265.2009.03732.x

Citationsformater

Fernández-Pérez, L., Nóvoa, J., Ståhlberg, N., Santana-Farré, R., Boronat, M., Marrero, D., Henríquez-Hernández, L., Norstedt, G., & Flores Morales, A. (2010). The effect of in vivo growth hormone treatment on blood gene expression in adults with growth hormone deficiency reveals potential biomarkers to monitor growth hormone therapy. Clinical Endocrinology, 72(6), 800-6. https://doi.org/10.1111/j.1365-2265.2009.03732.x

The effect of in vivo growth hormone treatment on blood gene expression in adults with growth hormone deficiency reveals potential biomarkers to monitor growth hormone therapy. / Fernández-Pérez, L; Nóvoa, J; Ståhlberg, N et al.
I: Clinical Endocrinology, Bind 72, Nr. 6, 2010, s. 800-6.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Fernández-Pérez, L, Nóvoa, J, Ståhlberg, N, Santana-Farré, R, Boronat, M, Marrero, D, Henríquez-Hernández, L, Norstedt, G & Flores Morales, A 2010, 'The effect of in vivo growth hormone treatment on blood gene expression in adults with growth hormone deficiency reveals potential biomarkers to monitor growth hormone therapy', Clinical Endocrinology, bind 72, nr. 6, s. 800-6. https://doi.org/10.1111/j.1365-2265.2009.03732.x

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abstract = "Growth hormone (GH) replacement therapy is presently utilized in the treatment of adult GH deficiency (AGHD). Adult responses to GH treatment are highly variable and, apart from measurement of IGF-I, few tools are currently available for monitoring GH treatment progress. As GH receptors are expressed in certain blood cell types, changes in gene expression in peripheral blood can reflect perturbations induced as a result of GH therapy.",

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AU - Fernández-Pérez, L

AU - Nóvoa, J

AU - Ståhlberg, N

AU - Santana-Farré, R

AU - Boronat, M

AU - Marrero, D

AU - Henríquez-Hernández, L

AU - Norstedt, G

AU - Flores Morales, Amilcar

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AB - Growth hormone (GH) replacement therapy is presently utilized in the treatment of adult GH deficiency (AGHD). Adult responses to GH treatment are highly variable and, apart from measurement of IGF-I, few tools are currently available for monitoring GH treatment progress. As GH receptors are expressed in certain blood cell types, changes in gene expression in peripheral blood can reflect perturbations induced as a result of GH therapy.

U2 - 10.1111/j.1365-2265.2009.03732.x

DO - 10.1111/j.1365-2265.2009.03732.x

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