The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer

Christian W Wang; Cornelus C Hermsen; Robert W Sauerwein; David E Arnot; Thor G Theander; Thomas Lavstsen

doi:10.1016/j.parint.2009.07.004

The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer

Christian W Wang, Cornelus C Hermsen, Robert W Sauerwein, David E Arnot, Thor G Theander, Thomas Lavstsen

DISCOVERY team

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

55 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Dec

Originalsprog	Engelsk
Tidsskrift	Parasitology International
Vol/bind	58
Udgave nummer	4
Sider (fra-til)	478-80
Antal sider	2
ISSN	1383-5769
DOI	https://doi.org/10.1016/j.parint.2009.07.004
Status	Udgivet - 2009

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10.1016/j.parint.2009.07.004

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Citationsformater

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title = "The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer",

abstract = "The var genes encode a family of adhesion receptor proteins, Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), which profoundly influence malaria pathogenesis. Only a single var gene is transcribed and one PfEMP1 expressed per P.falciparum parasite. Here we present the in vivo transcript distribution of var genes in a P. falciparum-infected non-immune individual and show that the initial expression of PfEMP1 is based on a strategy that allows all or most variants of PfEMP1s to be expressed by the parasite population at the onset of the blood stage infection.",

author = "Wang, {Christian W} and Hermsen, {Cornelus C} and Sauerwein, {Robert W} and Arnot, {David E} and Theander, {Thor G} and Thomas Lavstsen",

year = "2009",

doi = "10.1016/j.parint.2009.07.004",

language = "English",

volume = "58",

pages = "478--80",

journal = "Parasitology International",

issn = "1383-5769",

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TY - JOUR

T1 - The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer

AU - Wang, Christian W

AU - Hermsen, Cornelus C

AU - Sauerwein, Robert W

AU - Arnot, David E

AU - Theander, Thor G

AU - Lavstsen, Thomas

PY - 2009

Y1 - 2009

N2 - The var genes encode a family of adhesion receptor proteins, Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), which profoundly influence malaria pathogenesis. Only a single var gene is transcribed and one PfEMP1 expressed per P.falciparum parasite. Here we present the in vivo transcript distribution of var genes in a P. falciparum-infected non-immune individual and show that the initial expression of PfEMP1 is based on a strategy that allows all or most variants of PfEMP1s to be expressed by the parasite population at the onset of the blood stage infection.

AB - The var genes encode a family of adhesion receptor proteins, Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), which profoundly influence malaria pathogenesis. Only a single var gene is transcribed and one PfEMP1 expressed per P.falciparum parasite. Here we present the in vivo transcript distribution of var genes in a P. falciparum-infected non-immune individual and show that the initial expression of PfEMP1 is based on a strategy that allows all or most variants of PfEMP1s to be expressed by the parasite population at the onset of the blood stage infection.

U2 - 10.1016/j.parint.2009.07.004

DO - 10.1016/j.parint.2009.07.004

M3 - Journal article

C2 - 19616120

SN - 1383-5769

VL - 58

SP - 478

EP - 480

JO - Parasitology International

JF - Parasitology International

IS - 4

ER -