TY - JOUR
T1 - The fission yeast heterochromatin protein Rik1 is required for telomere clustering during meiosis
AU - Tuzon, Creighton T
AU - Borgstrøm, Britta
AU - Weilguny, Dietmar
AU - Egel, Richard
AU - Cooper, Julia Promisel
AU - Nielsen, Olaf
N1 - Keywords: Chromosomal Proteins, Non-Histone; Cloning, Molecular; Gene Deletion; Heterochromatin; Meiosis; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Telomere
PY - 2004
Y1 - 2004
N2 - Telomeres share the ability to silence nearby transcription with heterochromatin, but the requirement of heterochromatin proteins for most telomere functions is unknown. The fission yeast Rik1 protein is required for heterochromatin formation at centromeres and the mating-type locus, as it recruits the Clr4 histone methyltransferase, whose modification of histone H3 triggers binding by Swi6, a conserved protein involved in spreading of heterochromatin. Here, we demonstrate that Rik1 and Clr4, but not Swi6, are required along with the telomere protein Taz1 for crucial chromosome movements during meiosis. However, Rik1 is dispensable for the protective roles of telomeres in preventing chromosome end-fusion. Thus, a Swi6-independent heterochromatin function distinct from that at centromeres and the mating-type locus operates at telomeres during sexual differentiation.
AB - Telomeres share the ability to silence nearby transcription with heterochromatin, but the requirement of heterochromatin proteins for most telomere functions is unknown. The fission yeast Rik1 protein is required for heterochromatin formation at centromeres and the mating-type locus, as it recruits the Clr4 histone methyltransferase, whose modification of histone H3 triggers binding by Swi6, a conserved protein involved in spreading of heterochromatin. Here, we demonstrate that Rik1 and Clr4, but not Swi6, are required along with the telomere protein Taz1 for crucial chromosome movements during meiosis. However, Rik1 is dispensable for the protective roles of telomeres in preventing chromosome end-fusion. Thus, a Swi6-independent heterochromatin function distinct from that at centromeres and the mating-type locus operates at telomeres during sexual differentiation.
U2 - 10.1083/jcb.200312061
DO - 10.1083/jcb.200312061
M3 - Journal article
C2 - 15197176
VL - 165
SP - 759
EP - 765
JO - Journal of Cell Biology
JF - Journal of Cell Biology
SN - 0021-9525
IS - 6
ER -