The imprinted gene neuronatin is regulated by metabolic status and associated with obesity

Niels Vrang; David Meyre; Phillippe Froguel; Jacob Jelsing; Mads Tang-Christensen; Vincent Vatin; Jens D Mikkelsen; Kenneth Thirstrup; Leif K Larsen; Karina B Cullberg; Jan Fahrenkrug; Per Jacobson; Lars Sjöström; Lena M S Carlsson; Yongjun Liu; Xiaogang Liu; Hong-Wen Deng; Philip J Larsen

doi:10.1038/oby.2009.361

The imprinted gene neuronatin is regulated by metabolic status and associated with obesity

Niels Vrang, David Meyre, Phillippe Froguel, Jacob Jelsing, Mads Tang-Christensen, Vincent Vatin, Jens D Mikkelsen, Kenneth Thirstrup, Leif K Larsen, Karina B Cullberg, Jan Fahrenkrug, Per Jacobson, Lars Sjöström, Lena M S Carlsson, Yongjun Liu, Xiaogang Liu, Hong-Wen Deng, Philip J Larsen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

57 Citationer (Scopus)

Abstract

Using restriction fragment differential display (RFDD) technology, we have identified the imprinted gene neuronatin (Nnat) as a hypothalamic target under the influence of leptin. Nnat mRNA expression is decreased in several key appetite regulatory hypothalamic nuclei in rodents with impaired leptin signaling and during fasting conditions. Furthermore, peripheral administration of leptin to ob/ob mice normalizes hypothalamic Nnat expression. Comparative immunohistochemical analysis of human and rat hypothalami demonstrates that NNAT protein is present in anatomically equivalent nuclei, suggesting human physiological relevance of the gene product(s). A putative role of Nnat in human energy homeostasis is further emphasized by a consistent association between single nucleotide polymorphisms (SNPs) in the human Nnat gene and severe childhood and adult obesity.

Originalsprog	Engelsk
Tidsskrift	Obesity
Vol/bind	18
Udgave nummer	7
Sider (fra-til)	1289-96
Antal sider	8
ISSN	1930-7381
DOI	https://doi.org/10.1038/oby.2009.361
Status	Udgivet - 1 jul. 2010

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Vrang, N., Meyre, D., Froguel, P., Jelsing, J., Tang-Christensen, M., Vatin, V., Mikkelsen, J. D., Thirstrup, K., Larsen, L. K., Cullberg, K. B., Fahrenkrug, J., Jacobson, P., Sjöström, L., Carlsson, L. M. S., Liu, Y., Liu, X., Deng, H.-W., & Larsen, P. J. (2010). The imprinted gene neuronatin is regulated by metabolic status and associated with obesity. Obesity, 18(7), 1289-96. https://doi.org/10.1038/oby.2009.361

Vrang, N, Meyre, D, Froguel, P, Jelsing, J, Tang-Christensen, M, Vatin, V, Mikkelsen, JD, Thirstrup, K, Larsen, LK, Cullberg, KB, Fahrenkrug, J, Jacobson, P, Sjöström, L, Carlsson, LMS, Liu, Y, Liu, X, Deng, H-W & Larsen, PJ 2010, 'The imprinted gene neuronatin is regulated by metabolic status and associated with obesity', Obesity, bind 18, nr. 7, s. 1289-96. https://doi.org/10.1038/oby.2009.361

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title = "The imprinted gene neuronatin is regulated by metabolic status and associated with obesity",

abstract = "Using restriction fragment differential display (RFDD) technology, we have identified the imprinted gene neuronatin (Nnat) as a hypothalamic target under the influence of leptin. Nnat mRNA expression is decreased in several key appetite regulatory hypothalamic nuclei in rodents with impaired leptin signaling and during fasting conditions. Furthermore, peripheral administration of leptin to ob/ob mice normalizes hypothalamic Nnat expression. Comparative immunohistochemical analysis of human and rat hypothalami demonstrates that NNAT protein is present in anatomically equivalent nuclei, suggesting human physiological relevance of the gene product(s). A putative role of Nnat in human energy homeostasis is further emphasized by a consistent association between single nucleotide polymorphisms (SNPs) in the human Nnat gene and severe childhood and adult obesity.",

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doi = "10.1038/oby.2009.361",

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T1 - The imprinted gene neuronatin is regulated by metabolic status and associated with obesity

AU - Vrang, Niels

AU - Meyre, David

AU - Froguel, Phillippe

AU - Jelsing, Jacob

AU - Tang-Christensen, Mads

AU - Vatin, Vincent

AU - Mikkelsen, Jens D

AU - Thirstrup, Kenneth

AU - Larsen, Leif K

AU - Cullberg, Karina B

AU - Fahrenkrug, Jan

AU - Jacobson, Per

AU - Sjöström, Lars

AU - Carlsson, Lena M S

AU - Liu, Yongjun

AU - Liu, Xiaogang

AU - Deng, Hong-Wen

AU - Larsen, Philip J

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Using restriction fragment differential display (RFDD) technology, we have identified the imprinted gene neuronatin (Nnat) as a hypothalamic target under the influence of leptin. Nnat mRNA expression is decreased in several key appetite regulatory hypothalamic nuclei in rodents with impaired leptin signaling and during fasting conditions. Furthermore, peripheral administration of leptin to ob/ob mice normalizes hypothalamic Nnat expression. Comparative immunohistochemical analysis of human and rat hypothalami demonstrates that NNAT protein is present in anatomically equivalent nuclei, suggesting human physiological relevance of the gene product(s). A putative role of Nnat in human energy homeostasis is further emphasized by a consistent association between single nucleotide polymorphisms (SNPs) in the human Nnat gene and severe childhood and adult obesity.

AB - Using restriction fragment differential display (RFDD) technology, we have identified the imprinted gene neuronatin (Nnat) as a hypothalamic target under the influence of leptin. Nnat mRNA expression is decreased in several key appetite regulatory hypothalamic nuclei in rodents with impaired leptin signaling and during fasting conditions. Furthermore, peripheral administration of leptin to ob/ob mice normalizes hypothalamic Nnat expression. Comparative immunohistochemical analysis of human and rat hypothalami demonstrates that NNAT protein is present in anatomically equivalent nuclei, suggesting human physiological relevance of the gene product(s). A putative role of Nnat in human energy homeostasis is further emphasized by a consistent association between single nucleotide polymorphisms (SNPs) in the human Nnat gene and severe childhood and adult obesity.

U2 - 10.1038/oby.2009.361

DO - 10.1038/oby.2009.361

M3 - Journal article

SN - 1930-7381

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SP - 1289

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JO - Obesity

JF - Obesity

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ER -