@article{af05d7b0589511dd8d9f000ea68e967b,
title = "The integrin-actin connection, an eternal love affair.",
abstract = "Integrin receptors connect the extracellular matrix to the actin cytoskeleton. This interaction can be viewed as a cyclical liaison, which develops again and again at new adhesion sites only to cease at sites of de-adhesion. Recent work has demonstrated that multidomain proteins play crucial roles in the integrin-actin connection by providing a high degree of regulation adjusted to the needs of the cell. In this review we present several examples of this paradigm and with special emphasis on the ILK-PINCH-parvin complex, which amply demonstrates how structural and signalling functions are linked together.",
author = "Cord Brakebusch and Reinhard F{\"a}ssler",
note = "Keywords: Actinin; Actins; Animals; Carrier Proteins; Cell Adhesion; Cytoskeleton; DNA-Binding Proteins; Extracellular Matrix; Focal Adhesion Protein-Tyrosine Kinases; Integrins; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Microfilament Proteins; Protein-Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction",
year = "2003",
doi = "10.1093/emboj/cdg245",
language = "English",
volume = "22",
pages = "2324--33",
journal = "E M B O Journal",
issn = "0261-4189",
publisher = "Wiley-Blackwell",
number = "10",
}