The interactive effects of selenomethionine and methylmercury on their absorption, disposition, and elimination in juvenile white sturgeon

Susie Shih-Yin Huang, Anders Bjerring Strathe, James G. Fadel, Michael L. Johnson, Pinpin Lin, Tsung-Yun Liu, Silas S. O. Hung

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    23 Citationer (Scopus)

    Abstract

    Selenium (Se) and mercury (Hg) are prevalent pollutants of industrialized watersheds. However, when co-administered, Se has protective effects on organisms from Hg. The mechanism is not fully understood, but it is thought that Se reduces Hg availability, either by forming biologically inert complexes and/or associating with selenoproteins. Despite concerns with aquatic contaminations, relatively little information is available on the interaction in aquatic organisms. In the present study, the interactive effects of Se and Hg on their absorption, disposition, and elimination were examined in juvenile white sturgeon, a benthic fish species at high risk to exposures of both contaminants. Selenium and Hg were provided as L-selenomethionine (SeMet) and methylmercury (MeHg), respectively. Groups of 10 sturgeon were orally intubated with a single dose of either 0 (control), SeMet (500 µg Se/kg body weight; BW), MeHg (850 µg Hg/kg BW), or their combination (Se/Hg; 500 µg Se/kg and 850 µg Hg/kg BW). The blood was repeatedly sampled and urine collected from the fish, over a 48 h post intubation period. At 48 h, the fish were sacrificed for Se and Hg tissue concentration and distribution. The co-administration of SeMet and MeHg significantly (p
    OriginalsprogEngelsk
    TidsskriftAquatic Toxicology
    Vol/bind126
    Sider (fra-til)274-282
    Antal sider9
    ISSN0166-445X
    DOI
    StatusUdgivet - 2013

    Citationsformater