TY - JOUR
T1 - The interactive effects of selenomethionine and methylmercury on their absorption, disposition, and elimination in juvenile white sturgeon
AU - Huang, Susie Shih-Yin
AU - Strathe, Anders Bjerring
AU - Fadel, James G.
AU - Johnson, Michael L.
AU - Lin, Pinpin
AU - Liu, Tsung-Yun
AU - Hung, Silas S. O.
N1 - Copyright © 2012 Elsevier B.V. All rights reserved.
PY - 2013
Y1 - 2013
N2 - Selenium (Se) and mercury (Hg) are prevalent pollutants of industrialized watersheds. However, when co-administered, Se has protective effects on organisms from Hg. The mechanism is not fully understood, but it is thought that Se reduces Hg availability, either by forming biologically inert complexes and/or associating with selenoproteins. Despite concerns with aquatic contaminations, relatively little information is available on the interaction in aquatic organisms. In the present study, the interactive effects of Se and Hg on their absorption, disposition, and elimination were examined in juvenile white sturgeon, a benthic fish species at high risk to exposures of both contaminants. Selenium and Hg were provided as L-selenomethionine (SeMet) and methylmercury (MeHg), respectively. Groups of 10 sturgeon were orally intubated with a single dose of either 0 (control), SeMet (500 µg Se/kg body weight; BW), MeHg (850 µg Hg/kg BW), or their combination (Se/Hg; 500 µg Se/kg and 850 µg Hg/kg BW). The blood was repeatedly sampled and urine collected from the fish, over a 48 h post intubation period. At 48 h, the fish were sacrificed for Se and Hg tissue concentration and distribution. The co-administration of SeMet and MeHg significantly (p
AB - Selenium (Se) and mercury (Hg) are prevalent pollutants of industrialized watersheds. However, when co-administered, Se has protective effects on organisms from Hg. The mechanism is not fully understood, but it is thought that Se reduces Hg availability, either by forming biologically inert complexes and/or associating with selenoproteins. Despite concerns with aquatic contaminations, relatively little information is available on the interaction in aquatic organisms. In the present study, the interactive effects of Se and Hg on their absorption, disposition, and elimination were examined in juvenile white sturgeon, a benthic fish species at high risk to exposures of both contaminants. Selenium and Hg were provided as L-selenomethionine (SeMet) and methylmercury (MeHg), respectively. Groups of 10 sturgeon were orally intubated with a single dose of either 0 (control), SeMet (500 µg Se/kg body weight; BW), MeHg (850 µg Hg/kg BW), or their combination (Se/Hg; 500 µg Se/kg and 850 µg Hg/kg BW). The blood was repeatedly sampled and urine collected from the fish, over a 48 h post intubation period. At 48 h, the fish were sacrificed for Se and Hg tissue concentration and distribution. The co-administration of SeMet and MeHg significantly (p
KW - Absorption
KW - Animals
KW - Drug Interactions
KW - Fishes
KW - Methylmercury Compounds
KW - Selenomethionine
KW - Tissue Distribution
KW - Water Pollutants, Chemical
U2 - 10.1016/j.aquatox.2012.09.018
DO - 10.1016/j.aquatox.2012.09.018
M3 - Journal article
C2 - 23089250
VL - 126
SP - 274
EP - 282
JO - Aquatic Toxicology
JF - Aquatic Toxicology
SN - 0166-445X
ER -