The interleukin-1 receptor antagonist anakinra improves first-phase insulin secretion and insulinogenic index in subjects with impaired glucose tolerance

P C M van Poppel, E J P van Asseldonk, Jens Juul Holst, Tina Vilsbøll, M G Netea, C J Tack

Publikation: Bidrag til tidsskriftLetterForskningpeer review

27 Citationer (Scopus)

Abstract

Inflammation at the level of the β cell appears to be involved in progressive β-cell dysfunction in type 2 diabetes. We assessed the effect of blocking interleukin-1 (IL-1) by anakinra [recombinant human interleukin-1 receptor antagonist (IL-1Ra)] on β-cell function. Sixteen participants with impaired glucose tolerance were treated with 150 mg anakinra daily for 4 weeks in a double blind, randomized, placebo-controlled cross-over study with a wash-out period of 4 weeks. At the end of each treatment period, oral glucose tolerance tests (OGTTs) and hyperglycaemic clamps were performed. First-phase insulin secretion improved after anakinra treatment compared with placebo, 148 ± 20 versus 123 ± 14 mU/l, respectively (p = 0.03), and the insulinogenic index was higher after anakinra treatment. These results support the concept of involvement of IL-1β in the (progressive) decrease of insulin secretion capacity associated with type 2 diabetes.

OriginalsprogEngelsk
TidsskriftDiabetes, Obesity and Metabolism
Vol/bind16
Udgave nummer12
Sider (fra-til)1269-73
Antal sider5
ISSN1462-8902
DOI
StatusUdgivet - dec. 2014

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