The Landscape of Atypical and Eukaryotic Protein Kinases

Georgi K Kanev, Chris de Graaf, Iwan J P de Esch, Rob Leurs, Thomas Würdinger, Bart A Westerman, Albert J Kooistra

Publikation: Bidrag til tidsskriftReviewForskningpeer review

88 Citationer (Scopus)
80 Downloads (Pure)

Abstract

Kinases are attractive anticancer targets due to their central role in the growth, survival, and therapy resistance of tumor cells. This review explores the two primary kinase classes, the eukaryotic protein kinases (ePKs) and the atypical protein kinases (aPKs), and provides a structure-centered comparison of their sequences, structures, hydrophobic spines, mutation and SNP hotspots, and inhibitor interaction patterns. Despite the limited sequence similarity between these two classes, atypical kinases commonly share the archetypical kinase fold but lack conserved eukaryotic kinase motifs and possess altered hydrophobic spines. Furthermore, atypical kinase inhibitors explore only a limited number of binding modes both inside and outside the orthosteric binding site. The distribution of genetic variations in both classes shows multiple ways they can interfere with kinase inhibitor binding. This multilayered review provides a research framework bridging the eukaryotic and atypical kinase classes.

OriginalsprogEngelsk
TidsskriftTrends in Pharmacological Sciences
Vol/bind40
Udgave nummer11
Sider (fra-til)818-832
Antal sider15
ISSN0165-6147
DOI
StatusUdgivet - nov. 2019
Udgivet eksterntJa

Bibliografisk note

Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.

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