The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing

L Luu; F F Dai; K J Prentice; X Huang; A B Hardy; Jakob Bondo Hansen; Y Liu; J W Joseph; M B Wheeler

doi:10.1007/s00125-013-2946-5

The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing

L Luu, F F Dai, K J Prentice, X Huang, A B Hardy, Jakob Bondo Hansen, Y Liu, J W Joseph, M B Wheeler

Endocrinology and Metabolism

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

72 Citationer (Scopus)

Abstract

Sirtuin 1 (SIRT1) has emerged as a key metabolic regulator of glucose homeostasis and insulin secretion. Enhanced SIRT1 activity has been shown to be protective against diabetes, although the mechanisms remain largely unknown. The aim of this study was to determine how SIRT1 regulates insulin secretion in the pancreatic beta cell.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	56
Udgave nummer	9
Sider (fra-til)	2010-20
Antal sider	11
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-013-2946-5
Status	Udgivet - sep. 2013

Adgang til dokumentet

10.1007/s00125-013-2946-5

Citationsformater

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title = "The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing",

abstract = "Sirtuin 1 (SIRT1) has emerged as a key metabolic regulator of glucose homeostasis and insulin secretion. Enhanced SIRT1 activity has been shown to be protective against diabetes, although the mechanisms remain largely unknown. The aim of this study was to determine how SIRT1 regulates insulin secretion in the pancreatic beta cell.",

author = "L Luu and Dai, {F F} and Prentice, {K J} and X Huang and Hardy, {A B} and Hansen, {Jakob Bondo} and Y Liu and Joseph, {J W} and Wheeler, {M B}",

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AU - Luu, L

AU - Dai, F F

AU - Prentice, K J

AU - Huang, X

AU - Hardy, A B

AU - Hansen, Jakob Bondo

AU - Liu, Y

AU - Joseph, J W

AU - Wheeler, M B

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AB - Sirtuin 1 (SIRT1) has emerged as a key metabolic regulator of glucose homeostasis and insulin secretion. Enhanced SIRT1 activity has been shown to be protective against diabetes, although the mechanisms remain largely unknown. The aim of this study was to determine how SIRT1 regulates insulin secretion in the pancreatic beta cell.

U2 - 10.1007/s00125-013-2946-5

DO - 10.1007/s00125-013-2946-5

M3 - Journal article

C2 - 23783352

SN - 0012-186X

VL - 56

SP - 2010

EP - 2020

JO - Diabetologia

JF - Diabetologia

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