TY - JOUR
T1 - The Notch pathway in cancer: differentiation gone awry.
AU - Sjölund, Jonas
AU - Manetopulos, Anna Kristina
AU - Stockhausen, Marie-Thérése
AU - Axelson, Håkan
N1 - Keywords: Animals; Breast Neoplasms; Carcinoma, Mucoepidermoid; Cell Transformation, Neoplastic; Epstein-Barr Virus Infections; Humans; Leukemia-Lymphoma, Adult T-Cell; Medulloblastoma; Mice; Receptors, Notch
PY - 2005
Y1 - 2005
N2 - The Notch signalling cascade influences several key aspects of normal development by regulating differentiation, proliferation and apoptosis. Its association to human cancer is firmly established in T-cell leukaemia where point mutations or chromosomal translocations lead to constitutive signalling. Accumulating data indicate that deregulated Notch activity is involved also in the genesis of other human cancers, such as pancreatic cancer, medulloblastoma and mucoepidermoid carcinoma. In these tumours, the oncogenic effect of Notch signalling reflects an aberrant recapitulation of the highly tissue-specific function of the cascade during normal development and in tissue homeostasis.
AB - The Notch signalling cascade influences several key aspects of normal development by regulating differentiation, proliferation and apoptosis. Its association to human cancer is firmly established in T-cell leukaemia where point mutations or chromosomal translocations lead to constitutive signalling. Accumulating data indicate that deregulated Notch activity is involved also in the genesis of other human cancers, such as pancreatic cancer, medulloblastoma and mucoepidermoid carcinoma. In these tumours, the oncogenic effect of Notch signalling reflects an aberrant recapitulation of the highly tissue-specific function of the cascade during normal development and in tissue homeostasis.
U2 - 10.1016/j.ejca.2005.06.025
DO - 10.1016/j.ejca.2005.06.025
M3 - Journal article
C2 - 16239105
SN - 0959-8049
VL - 41
SP - 2620
EP - 2629
JO - European Journal of Cancer
JF - European Journal of Cancer
IS - 17
ER -