Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | NeuroImage |
| Vol/bind | 45 |
| Udgave nummer | 2 |
| Sider (fra-til) | 280-5 |
| Antal sider | 5 |
| ISSN | 1053-8119 |
| DOI | |
| Status | Udgivet - 2009 |
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The personality trait openness is related to cerebral 5-HTT levels. / Kalbitzer, Jan; Frokjaer, Vibe G; Erritzoe, David; Svarer, Claus; Cumming, Paul; Nielsen, Finn A; Hashemi, Sayed H; Baaré, William F C; Madsen, Jacob; Hasselbalch, Steen G; Kringelbach, Morten L; Mortensen, Erik Lykke; Knudsen, Gitte M.
I: NeuroImage, Bind 45, Nr. 2, 2009, s. 280-5.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - The personality trait openness is related to cerebral 5-HTT levels
AU - Kalbitzer, Jan
AU - Frokjaer, Vibe G
AU - Erritzoe, David
AU - Svarer, Claus
AU - Cumming, Paul
AU - Nielsen, Finn A
AU - Hashemi, Sayed H
AU - Baaré, William F C
AU - Madsen, Jacob
AU - Hasselbalch, Steen G
AU - Kringelbach, Morten L
AU - Mortensen, Erik Lykke
AU - Knudsen, Gitte M
PY - 2009
Y1 - 2009
N2 - Potentiation of serotonergic transmission increases cognitive flexibility, but can in other circumstances increase sensitivity to stressful environmental cues. The personality trait Openness to Experience reflects and is also associated with an increased risk for mood disorders. We hypothesized that the personality trait has an association with a biomarker of serotonergic transmission, the plasma membrane serotonin transporter (5-HTT). In 50 healthy volunteers, we tested for correlations between scores on the NEO-PI-R scale Openness to Experience and its subscales, and cerebral binding of the 5-HTT selective PET radioligand [11C]DASB. Subjects were genotyped for the 5-HTT long/short polymorphism, and for a single nucleotide polymorphism in the long allele, designated LA/LG. Midbrain [11C]DASB binding correlated negatively with scores for Openness to Experience and its two subscales, Openness to Actions and Openness to Values. The latter subscore was negatively correlated with [11C]DASB binding in all brain regions in which [11C]DASB binding was quantified. Genetic analysis showed that homozygote LA carriers had significantly higher [11C]DASB binding in the caudate nucleus, but no significant differences in openness scores. Thus, high scores in personality facets indicative of cognitive flexibility and openness to change are associated with lower [11C]DASB binding. Lower abundance of 5-HTT sites may result in potentiation of serotonergic signaling, which occurs during treatment with SSRIs. We speculate that the set-point of serotonergic signaling in an individual represents a trade-off between flexibility and vulnerability when exposed to environmental stress.
AB - Potentiation of serotonergic transmission increases cognitive flexibility, but can in other circumstances increase sensitivity to stressful environmental cues. The personality trait Openness to Experience reflects and is also associated with an increased risk for mood disorders. We hypothesized that the personality trait has an association with a biomarker of serotonergic transmission, the plasma membrane serotonin transporter (5-HTT). In 50 healthy volunteers, we tested for correlations between scores on the NEO-PI-R scale Openness to Experience and its subscales, and cerebral binding of the 5-HTT selective PET radioligand [11C]DASB. Subjects were genotyped for the 5-HTT long/short polymorphism, and for a single nucleotide polymorphism in the long allele, designated LA/LG. Midbrain [11C]DASB binding correlated negatively with scores for Openness to Experience and its two subscales, Openness to Actions and Openness to Values. The latter subscore was negatively correlated with [11C]DASB binding in all brain regions in which [11C]DASB binding was quantified. Genetic analysis showed that homozygote LA carriers had significantly higher [11C]DASB binding in the caudate nucleus, but no significant differences in openness scores. Thus, high scores in personality facets indicative of cognitive flexibility and openness to change are associated with lower [11C]DASB binding. Lower abundance of 5-HTT sites may result in potentiation of serotonergic signaling, which occurs during treatment with SSRIs. We speculate that the set-point of serotonergic signaling in an individual represents a trade-off between flexibility and vulnerability when exposed to environmental stress.
U2 - 10.1016/j.neuroimage.2008.12.001
DO - 10.1016/j.neuroimage.2008.12.001
M3 - Journal article
C2 - 19135154
VL - 45
SP - 280
EP - 285
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 2
ER -