Abstract
Originalsprog | Engelsk |
---|---|
Tidsskrift | Bone Marrow Transplantation |
Vol/bind | 43 |
Udgave nummer | 7 |
Sider (fra-til) | 539-45 |
Antal sider | 6 |
ISSN | 0268-3369 |
DOI | |
Status | Udgivet - 2008 |
Bibliografisk note
Keywords: Aged; Female; Haplotypes; Humans; Interleukin-1beta; Male; Middle Aged; Multiple Myeloma; Multivariate Analysis; Polymorphism, Single Nucleotide; Prognosis; Stem Cell Transplantation; Survival Analysis; Transplantation, AutologousAdgang til dokumentet
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The polymorphism IL-1beta T-31C is associated with a longer overall survival in patients with multiple myeloma undergoing auto-SCT. / Vangsted, A J; Klausen, T W; Ruminski, W; Gimsing, P; Andersen, N F; Gang, A O; Abildgaard, N; Knudsen, L M; Nielsen, J L; Gregersen, H; Vogel, U.
I: Bone Marrow Transplantation, Bind 43, Nr. 7, 2008, s. 539-45.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - The polymorphism IL-1beta T-31C is associated with a longer overall survival in patients with multiple myeloma undergoing auto-SCT
AU - Vangsted, A J
AU - Klausen, T W
AU - Ruminski, W
AU - Gimsing, P
AU - Andersen, N F
AU - Gang, A O
AU - Abildgaard, N
AU - Knudsen, L M
AU - Nielsen, J L
AU - Gregersen, H
AU - Vogel, U
N1 - Keywords: Aged; Female; Haplotypes; Humans; Interleukin-1beta; Male; Middle Aged; Multiple Myeloma; Multivariate Analysis; Polymorphism, Single Nucleotide; Prognosis; Stem Cell Transplantation; Survival Analysis; Transplantation, Autologous
PY - 2008
Y1 - 2008
N2 - Proinflammatory cytokines are suspected to play a role in the pathogenesis of multiple myeloma (MM). Therefore, it is possible that inborn genetic variations leading to a modified expression of these cytokines will influence the outcome for these patients. We investigated 348 MM patients undergoing high-dose melphalan treatment followed by Auto-SCT and examined the influence of single nucleotide polymorphisms (SNPs) in genes involved in the inflammatory response. We found that the polymorphism IL-1beta T-31C significantly influenced overall survival (OS; P=0.02) and that carriers of the variant C-allele had a significantly longer survival than homozygous wild-type allele TT-carriers (relative risk 0.6 (95% CI=0.5-0.9); P=0.008). The polymorphisms IL-6 G-174C, IL-10 C592A, PPARgamma2 Pro(12)Ala, COX-2 A-1195G, COX-2 T8473C and NFKB1 ins/del did not influence the OS in this group of patients. Furthermore, homozygous carriers of the variant allele of IL-1beta T-31C were at 1.37-fold (CI=1.05-1.80) increased risk of MM as compared with population-based controls (P=0.02). Our results indicate that IL-1beta is involved in the pathogenesis of MM.
AB - Proinflammatory cytokines are suspected to play a role in the pathogenesis of multiple myeloma (MM). Therefore, it is possible that inborn genetic variations leading to a modified expression of these cytokines will influence the outcome for these patients. We investigated 348 MM patients undergoing high-dose melphalan treatment followed by Auto-SCT and examined the influence of single nucleotide polymorphisms (SNPs) in genes involved in the inflammatory response. We found that the polymorphism IL-1beta T-31C significantly influenced overall survival (OS; P=0.02) and that carriers of the variant C-allele had a significantly longer survival than homozygous wild-type allele TT-carriers (relative risk 0.6 (95% CI=0.5-0.9); P=0.008). The polymorphisms IL-6 G-174C, IL-10 C592A, PPARgamma2 Pro(12)Ala, COX-2 A-1195G, COX-2 T8473C and NFKB1 ins/del did not influence the OS in this group of patients. Furthermore, homozygous carriers of the variant allele of IL-1beta T-31C were at 1.37-fold (CI=1.05-1.80) increased risk of MM as compared with population-based controls (P=0.02). Our results indicate that IL-1beta is involved in the pathogenesis of MM.
U2 - 10.1038/bmt.2008.351
DO - 10.1038/bmt.2008.351
M3 - Journal article
C2 - 18997828
VL - 43
SP - 539
EP - 545
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
SN - 0268-3369
IS - 7
ER -