The quality of life among first-episode psychotic patients in the OPUS trial

Anne Thorup; Lone Petersen; Pia Jeppesen; Merete Nordentoft

doi:10.1016/j.schres.2009.10.006

The quality of life among first-episode psychotic patients in the OPUS trial

Anne Thorup, Lone Petersen, Pia Jeppesen, Merete Nordentoft

Ph.d.-studienævnet for Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

37 Citationer (Scopus)

Abstract

Udgivelsesdato: 2010-Jan

Originalsprog	Engelsk
Tidsskrift	Schizophrenia Research
Vol/bind	116
Udgave nummer	1
Sider (fra-til)	27-34
Antal sider	7
ISSN	0920-9964
DOI	https://doi.org/10.1016/j.schres.2009.10.006
Status	Udgivet - 2010

Bibliografisk note

Keywords: Adult; Assertiveness; Behavior Therapy; Community Mental Health Services; Denmark; Female; Humans; Longitudinal Studies; Male; Psychiatric Status Rating Scales; Psychotic Disorders; Quality of Life; Retrospective Studies; Treatment Outcome; Young Adult

Adgang til dokumentet

10.1016/j.schres.2009.10.006

Citationsformater

@article{4bd2420946504b1a904fefe8bcfd7392,

title = "The quality of life among first-episode psychotic patients in the OPUS trial",

abstract = "BACKGROUND: From an 'objective' perspective, treatment of first-episode psychosis has improved in many ways with the development of specialised early and intensive team-based treatment like e.g. the 'OPUS' treatment. However, the patients' perspective is also important and was investigated in the 'OPUS' study by analysing data concerning quality of life. AIM: We aimed to investigate the 'quality of life from patients' perspective' among a cohort of young adults with a first-episode psychosis at the time of treatment initiation and after two years. Especially, we were interested in analysing if there were any significant effects on the subjective quality of life of receiving an intensive psychosocial assertive community treatment called 'OPUS' compared to standard treatment (ST). METHOD: This study is part of the Danish 'OPUS' trial, a randomised controlled trial (RCT) comparing 'treatment as usual' (standard treatment, ST) with 'OPUS' treatment. The Lancashire Quality of Life Profile (LQoLP), which is a combined objective and subjective instrument, was administered at baseline and after two years of treatment, N=280. RESULTS: The intensive 'OPUS' treatment did not affect the quality of life measured by Lancashire QoLP in a significantly different way from the standard treatment (ST). There were no significant differences in quality of life between the ST group and the OPUS group concerning the 9 life domains. Quality of life correlated with psychopathology (both psychotic and negative symptoms) to a minor extent and more strongly with the affective balance and level of self-esteem.",

author = "Anne Thorup and Lone Petersen and Pia Jeppesen and Merete Nordentoft",

note = "Keywords: Adult; Assertiveness; Behavior Therapy; Community Mental Health Services; Denmark; Female; Humans; Longitudinal Studies; Male; Psychiatric Status Rating Scales; Psychotic Disorders; Quality of Life; Retrospective Studies; Treatment Outcome; Young Adult",

year = "2010",

doi = "10.1016/j.schres.2009.10.006",

language = "English",

volume = "116",

pages = "27--34",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier",

number = "1",

}

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T1 - The quality of life among first-episode psychotic patients in the OPUS trial

AU - Thorup, Anne

AU - Petersen, Lone

AU - Jeppesen, Pia

AU - Nordentoft, Merete

N1 - Keywords: Adult; Assertiveness; Behavior Therapy; Community Mental Health Services; Denmark; Female; Humans; Longitudinal Studies; Male; Psychiatric Status Rating Scales; Psychotic Disorders; Quality of Life; Retrospective Studies; Treatment Outcome; Young Adult

PY - 2010

Y1 - 2010

N2 - BACKGROUND: From an 'objective' perspective, treatment of first-episode psychosis has improved in many ways with the development of specialised early and intensive team-based treatment like e.g. the 'OPUS' treatment. However, the patients' perspective is also important and was investigated in the 'OPUS' study by analysing data concerning quality of life. AIM: We aimed to investigate the 'quality of life from patients' perspective' among a cohort of young adults with a first-episode psychosis at the time of treatment initiation and after two years. Especially, we were interested in analysing if there were any significant effects on the subjective quality of life of receiving an intensive psychosocial assertive community treatment called 'OPUS' compared to standard treatment (ST). METHOD: This study is part of the Danish 'OPUS' trial, a randomised controlled trial (RCT) comparing 'treatment as usual' (standard treatment, ST) with 'OPUS' treatment. The Lancashire Quality of Life Profile (LQoLP), which is a combined objective and subjective instrument, was administered at baseline and after two years of treatment, N=280. RESULTS: The intensive 'OPUS' treatment did not affect the quality of life measured by Lancashire QoLP in a significantly different way from the standard treatment (ST). There were no significant differences in quality of life between the ST group and the OPUS group concerning the 9 life domains. Quality of life correlated with psychopathology (both psychotic and negative symptoms) to a minor extent and more strongly with the affective balance and level of self-esteem.

AB - BACKGROUND: From an 'objective' perspective, treatment of first-episode psychosis has improved in many ways with the development of specialised early and intensive team-based treatment like e.g. the 'OPUS' treatment. However, the patients' perspective is also important and was investigated in the 'OPUS' study by analysing data concerning quality of life. AIM: We aimed to investigate the 'quality of life from patients' perspective' among a cohort of young adults with a first-episode psychosis at the time of treatment initiation and after two years. Especially, we were interested in analysing if there were any significant effects on the subjective quality of life of receiving an intensive psychosocial assertive community treatment called 'OPUS' compared to standard treatment (ST). METHOD: This study is part of the Danish 'OPUS' trial, a randomised controlled trial (RCT) comparing 'treatment as usual' (standard treatment, ST) with 'OPUS' treatment. The Lancashire Quality of Life Profile (LQoLP), which is a combined objective and subjective instrument, was administered at baseline and after two years of treatment, N=280. RESULTS: The intensive 'OPUS' treatment did not affect the quality of life measured by Lancashire QoLP in a significantly different way from the standard treatment (ST). There were no significant differences in quality of life between the ST group and the OPUS group concerning the 9 life domains. Quality of life correlated with psychopathology (both psychotic and negative symptoms) to a minor extent and more strongly with the affective balance and level of self-esteem.

U2 - 10.1016/j.schres.2009.10.006

DO - 10.1016/j.schres.2009.10.006

M3 - Journal article

SN - 0920-9964

VL - 116

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EP - 34

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1

ER -