@article{b82cfbc0a07011dd86a6000ea68e967b,
title = "The relation between T-cell expression of LFA-1 and immunological memory",
abstract = "Antibodies against isotypes of the leucocyte common antigen (LCA, CD45) can be used to identify largely reciprocal subsets of human peripheral T cells, characterized by differential ability to respond to recall antigen in vitro. The transition from naive, unprimed T cells to memory cells capable of responding to recall stimulating has been associated with a switch in surface expression of CD45 from the CD45RA isotype to CD45RO. It has been proposed that this transition is accompanied by the coordinated up-regulation of a number of cell-surface molecules involved in cellular adhesion and/or activation, including the leucocyte function-associated antigens (LFA). In the present study we have examined the expression of LFA-1 on subsets of human peripheral T cells, and related it to the expression of markers of cellular activation and CD45 isotypes, and thus to immunological memory. Our results suggest that the intensity of LFA-1 expression on the surface membrane of human peripheral T cells is not tightly associated with maturation status as judged by LCA isotype expression, but rather reflects the degree of cellular activation. This conclusion is supported by data of T-cell function in vitro, showing similar antigen- and mitogen-induced proliferative responses in T-cell subsets characterized by low as well as high surface expression of LFA-1.",
author = "L Hviid and N Odum and Theander, {T G}",
note = "Keywords: Adult; Antigens, CD; Antigens, CD11; Antigens, CD45; Cell Adhesion Molecules; Cells, Cultured; Humans; Immunologic Memory; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Receptors, Interleukin-2; T-Lymphocyte Subsets; T-Lymphocytes",
year = "1993",
language = "English",
volume = "78",
pages = "237--43",
journal = "Immunology",
issn = "0019-2805",
publisher = "Wiley-Blackwell",
number = "2",
}