The role of antiretroviral therapy in the incidence of pancreatitis in HIV-positive individuals in the EuroSIDA study

Colette J Smith; Christian H Olsen; Amanda Mocroft; Jean Paul Viard; Schlomo Staszewski; George Panos; Therese Staub; Anders Blaxhult; Norbert Vetter; Jens Lundgren

doi:10.1097/QAD.0b013e3282f03094

The role of antiretroviral therapy in the incidence of pancreatitis in HIV-positive individuals in the EuroSIDA study

Colette J Smith, Christian H Olsen, Amanda Mocroft, Jean Paul Viard, Schlomo Staszewski, George Panos, Therese Staub, Anders Blaxhult, Norbert Vetter, Jens Lundgren

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

41 Citationer (Scopus)

Abstract

Udgivelsesdato: 2008-Jan-2

Originalsprog	Engelsk
Tidsskrift	AIDS
Vol/bind	22
Udgave nummer	1
Sider (fra-til)	47-56
Antal sider	9
ISSN	0269-9370
DOI	https://doi.org/10.1097/QAD.0b013e3282f03094
Status	Udgivet - 2008

Bibliografisk note

Keywords: Adult; Anti-Retroviral Agents; Argentina; CD4-Positive T-Lymphocytes; Case-Control Studies; Didanosine; Drug Therapy, Combination; Europe; Female; HIV; HIV Infections; Humans; Incidence; Israel; Lymphopenia; Male; Middle Aged; Pancreatitis; Reverse Transcriptase Inhibitors; Risk Factors; Stavudine

Adgang til dokumentet

10.1097/QAD.0b013e3282f03094

Citationsformater

@article{dc48f310ff3911ddb219000ea68e967b,

title = "The role of antiretroviral therapy in the incidence of pancreatitis in HIV-positive individuals in the EuroSIDA study",

abstract = "AIM: This study investigated the incidence of pancreatitis and its association with antiretroviral therapy (ART), focussing on stavudine and didanosine. METHODS: EuroSIDA has collected information on pancreatitis since Summer 2001. All identified cases have been verified by the coordinating centre. Individuals were followed from June 2001 or the date of entry into EuroSIDA (whichever occurred later) until a diagnosis of pancreatitis or the last study visit. Factors associated with pancreatitis were investigated using Poisson regression. Cumulative lengths of exposure to didanosine without stavudine, stavudine without didanosine, stavudine with didanosine, and other ART were time-updated variables. Treatment variables were fitted with a 6-month time lag. RESULTS: There were 43 (nine presumptive) pancreatic events in 9678 individuals during 33 742 person-years (incidence 1.27/1000 person-years). The incidence among those with no, 2 or less and over 2 years' exposure to ART including stavudine and didanosine was 1.24, 1.73 and 0.78/1000 person-years, respectively. In multivariable analysis, higher baseline CD4 cell counts were associated with a decreased risk of pancreatitis. There was no evidence of an association of pancreatitis with cumulative exposure to didanosine and stavudine, didanosine without stavudine, stavudine without didanosine, or other ART. CONCLUSION: We observed a low overall rate of pancreatitis in the years 2001-2006, and did not find an association of an increased incidence of pancreatitis with cumulative exposure to antiretroviral agents generally, and to didanosine and stavudine in particular.",

author = "Smith, {Colette J} and Olsen, {Christian H} and Amanda Mocroft and Viard, {Jean Paul} and Schlomo Staszewski and George Panos and Therese Staub and Anders Blaxhult and Norbert Vetter and Jens Lundgren",

note = "Keywords: Adult; Anti-Retroviral Agents; Argentina; CD4-Positive T-Lymphocytes; Case-Control Studies; Didanosine; Drug Therapy, Combination; Europe; Female; HIV; HIV Infections; Humans; Incidence; Israel; Lymphopenia; Male; Middle Aged; Pancreatitis; Reverse Transcriptase Inhibitors; Risk Factors; Stavudine",

year = "2008",

doi = "10.1097/QAD.0b013e3282f03094",

language = "English",

volume = "22",

pages = "47--56",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams & Wilkins, Ltd.",

number = "1",

}

TY - JOUR

T1 - The role of antiretroviral therapy in the incidence of pancreatitis in HIV-positive individuals in the EuroSIDA study

AU - Smith, Colette J

AU - Olsen, Christian H

AU - Mocroft, Amanda

AU - Viard, Jean Paul

AU - Staszewski, Schlomo

AU - Panos, George

AU - Staub, Therese

AU - Blaxhult, Anders

AU - Vetter, Norbert

AU - Lundgren, Jens

N1 - Keywords: Adult; Anti-Retroviral Agents; Argentina; CD4-Positive T-Lymphocytes; Case-Control Studies; Didanosine; Drug Therapy, Combination; Europe; Female; HIV; HIV Infections; Humans; Incidence; Israel; Lymphopenia; Male; Middle Aged; Pancreatitis; Reverse Transcriptase Inhibitors; Risk Factors; Stavudine

PY - 2008

Y1 - 2008

N2 - AIM: This study investigated the incidence of pancreatitis and its association with antiretroviral therapy (ART), focussing on stavudine and didanosine. METHODS: EuroSIDA has collected information on pancreatitis since Summer 2001. All identified cases have been verified by the coordinating centre. Individuals were followed from June 2001 or the date of entry into EuroSIDA (whichever occurred later) until a diagnosis of pancreatitis or the last study visit. Factors associated with pancreatitis were investigated using Poisson regression. Cumulative lengths of exposure to didanosine without stavudine, stavudine without didanosine, stavudine with didanosine, and other ART were time-updated variables. Treatment variables were fitted with a 6-month time lag. RESULTS: There were 43 (nine presumptive) pancreatic events in 9678 individuals during 33 742 person-years (incidence 1.27/1000 person-years). The incidence among those with no, 2 or less and over 2 years' exposure to ART including stavudine and didanosine was 1.24, 1.73 and 0.78/1000 person-years, respectively. In multivariable analysis, higher baseline CD4 cell counts were associated with a decreased risk of pancreatitis. There was no evidence of an association of pancreatitis with cumulative exposure to didanosine and stavudine, didanosine without stavudine, stavudine without didanosine, or other ART. CONCLUSION: We observed a low overall rate of pancreatitis in the years 2001-2006, and did not find an association of an increased incidence of pancreatitis with cumulative exposure to antiretroviral agents generally, and to didanosine and stavudine in particular.

AB - AIM: This study investigated the incidence of pancreatitis and its association with antiretroviral therapy (ART), focussing on stavudine and didanosine. METHODS: EuroSIDA has collected information on pancreatitis since Summer 2001. All identified cases have been verified by the coordinating centre. Individuals were followed from June 2001 or the date of entry into EuroSIDA (whichever occurred later) until a diagnosis of pancreatitis or the last study visit. Factors associated with pancreatitis were investigated using Poisson regression. Cumulative lengths of exposure to didanosine without stavudine, stavudine without didanosine, stavudine with didanosine, and other ART were time-updated variables. Treatment variables were fitted with a 6-month time lag. RESULTS: There were 43 (nine presumptive) pancreatic events in 9678 individuals during 33 742 person-years (incidence 1.27/1000 person-years). The incidence among those with no, 2 or less and over 2 years' exposure to ART including stavudine and didanosine was 1.24, 1.73 and 0.78/1000 person-years, respectively. In multivariable analysis, higher baseline CD4 cell counts were associated with a decreased risk of pancreatitis. There was no evidence of an association of pancreatitis with cumulative exposure to didanosine and stavudine, didanosine without stavudine, stavudine without didanosine, or other ART. CONCLUSION: We observed a low overall rate of pancreatitis in the years 2001-2006, and did not find an association of an increased incidence of pancreatitis with cumulative exposure to antiretroviral agents generally, and to didanosine and stavudine in particular.

U2 - 10.1097/QAD.0b013e3282f03094

DO - 10.1097/QAD.0b013e3282f03094

M3 - Journal article

C2 - 18090391

SN - 0269-9370

VL - 22

SP - 47

EP - 56

JO - AIDS

JF - AIDS

IS - 1

ER -