@article{44a21980832b11de8bc9000ea68e967b,
title = "The role of metallothionein II in neuronal differentiation and survival",
abstract = "Metallothionein I and II (MT-I+II) are antioxidant and tissue protective factors. We have previously shown that MT-I+II prevent oxidative stress and apoptotic cell death and are of therapeutic value in brain inflammation. However, MT-I+II are expressed in glia and it remains to be elucidated if MT-I+II can affect neurons directly. It is likely that MT isoforms could be beneficial also during neurodegenerative disorders. In this study, we have examined if MT-II affects survival and neurite extension of dopaminergic and hippocampal neurons. We show for the first time that MT-II treatment can significantly stimulate neurite extension from both dopaminergic and hippocampal neurons. Moreover, MT-II treatment significantly increases survival of dopaminergic neurons exposed to 6-hydroxydopamine (6-OHDA) and protects significantly hippocampal neurons from amyloid beta-peptide-induced neurotoxicity. Accordingly, treatment with MT-II may be of therapeutic value in neurodegenerative disorders.",
author = "K{\o}hler, {Lene B} and Vladimir Berezin and Elisabeth Bock and Milena Penkowa",
note = "Keywords: Adrenergic Agents; Amyloid beta-Protein; Animals; Animals, Newborn; Cell Differentiation; Cell Survival; Cells, Cultured; Dopamine; Embryo, Mammalian; Hippocampus; Metallothionein; Neurons; Neuroprotective Agents; Oxidopamine; Rats; Rats, Wistar",
year = "2003",
language = "English",
volume = "992",
pages = "128--36",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",
}