The role of SPECT-CT in the lymphoscintigraphic identification of sentinel nodes in patients with oral cancer

Anders Bilde; Christian Von Buchwald; Jann Mortensen; Jens Marving; Marianne Hamilton Therkildsen; Jørgen Kirkegaard; Birgitte Charabi; Lena Specht

doi:10.1080/00016480600794453

The role of SPECT-CT in the lymphoscintigraphic identification of sentinel nodes in patients with oral cancer

Anders Bilde, Christian Von Buchwald, Jann Mortensen, Jens Marving, Marianne Hamilton Therkildsen, Jørgen Kirkegaard, Birgitte Charabi, Lena Specht

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

61 Citationer (Scopus)

Abstract

Udgivelsesdato: 2006-Oct

Originalsprog	Engelsk
Tidsskrift	Acta Oto-Laryngologica
Vol/bind	126
Udgave nummer	10
Sider (fra-til)	1096-103
Antal sider	8
ISSN	0001-6489
DOI	https://doi.org/10.1080/00016480600794453
Status	Udgivet - 2006

Bibliografisk note

Keywords: Aged; Carcinoma, Squamous Cell; Cohort Studies; Female; Humans; Image Processing, Computer-Assisted; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Mouth Neoplasms; Neoplasm Staging; Prognosis; Prospective Studies; Tomography, Emission-Computed, Single-Photon

Adgang til dokumentet

10.1080/00016480600794453

Citationsformater

@article{e0891f304c7d11df928f000ea68e967b,

title = "The role of SPECT-CT in the lymphoscintigraphic identification of sentinel nodes in patients with oral cancer",

abstract = "CONCLUSION: SPECT-CT may improve the localization of sentinel nodes (SNs) in patients with oral squamous cell carcinoma (OSCC). Compared with planar lymphoscintigraphy SPECT-CT detected more SNs and provided additional anatomical and spatial information about their localization. New generation SPECT with higher resolution CT scanners are expected to provide more accurate information about the localization of SNs. OBJECTIVE: To assess the role of combined SPECT-CT in SN identification in the clinically negative neck of patients with OSCC. MATERIALS AND METHODS: Lymphoscintigraphy comprising planar and SPECT-CT acquisition was performed in 34 consecutive patients with OSCC stage I and II (T1-2N0M0) prior to sentinel node biopsy (SNB) and selective neck dissection. The number of SNs and anatomical location was recorded according to lymphoscintigraphy and operative findings. RESULTS: SNB was conducted in 33 patients. SNs were identified in 94% (32/34) of the patients using SPECT-CT. In 91% (29/32) of the patients SNs were harvested from all of the levels involved on SPECT-CT. SPECT-CT imaging demonstrated extra SNs compared with planar lymphoscintigraphic imaging in 47% (15/32) of patients. In seven cases the anatomical level of SN according to SPECT-CT was reclassified during surgery. The overall incidence of lymph node metastases was 19% (6/32). There were no false negative SNs.",

author = "Anders Bilde and {Von Buchwald}, Christian and Jann Mortensen and Jens Marving and {Hamilton Therkildsen}, Marianne and J{\o}rgen Kirkegaard and Birgitte Charabi and Lena Specht",

note = "Keywords: Aged; Carcinoma, Squamous Cell; Cohort Studies; Female; Humans; Image Processing, Computer-Assisted; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Mouth Neoplasms; Neoplasm Staging; Prognosis; Prospective Studies; Tomography, Emission-Computed, Single-Photon",

year = "2006",

doi = "10.1080/00016480600794453",

language = "English",

volume = "126",

pages = "1096--103",

journal = "Acta Oto-Laryngologica",

issn = "0001-6489",

publisher = "Taylor & Francis",

number = "10",

}

TY - JOUR

T1 - The role of SPECT-CT in the lymphoscintigraphic identification of sentinel nodes in patients with oral cancer

AU - Bilde, Anders

AU - Von Buchwald, Christian

AU - Mortensen, Jann

AU - Marving, Jens

AU - Hamilton Therkildsen, Marianne

AU - Kirkegaard, Jørgen

AU - Charabi, Birgitte

AU - Specht, Lena

N1 - Keywords: Aged; Carcinoma, Squamous Cell; Cohort Studies; Female; Humans; Image Processing, Computer-Assisted; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Mouth Neoplasms; Neoplasm Staging; Prognosis; Prospective Studies; Tomography, Emission-Computed, Single-Photon

PY - 2006

Y1 - 2006

N2 - CONCLUSION: SPECT-CT may improve the localization of sentinel nodes (SNs) in patients with oral squamous cell carcinoma (OSCC). Compared with planar lymphoscintigraphy SPECT-CT detected more SNs and provided additional anatomical and spatial information about their localization. New generation SPECT with higher resolution CT scanners are expected to provide more accurate information about the localization of SNs. OBJECTIVE: To assess the role of combined SPECT-CT in SN identification in the clinically negative neck of patients with OSCC. MATERIALS AND METHODS: Lymphoscintigraphy comprising planar and SPECT-CT acquisition was performed in 34 consecutive patients with OSCC stage I and II (T1-2N0M0) prior to sentinel node biopsy (SNB) and selective neck dissection. The number of SNs and anatomical location was recorded according to lymphoscintigraphy and operative findings. RESULTS: SNB was conducted in 33 patients. SNs were identified in 94% (32/34) of the patients using SPECT-CT. In 91% (29/32) of the patients SNs were harvested from all of the levels involved on SPECT-CT. SPECT-CT imaging demonstrated extra SNs compared with planar lymphoscintigraphic imaging in 47% (15/32) of patients. In seven cases the anatomical level of SN according to SPECT-CT was reclassified during surgery. The overall incidence of lymph node metastases was 19% (6/32). There were no false negative SNs.

AB - CONCLUSION: SPECT-CT may improve the localization of sentinel nodes (SNs) in patients with oral squamous cell carcinoma (OSCC). Compared with planar lymphoscintigraphy SPECT-CT detected more SNs and provided additional anatomical and spatial information about their localization. New generation SPECT with higher resolution CT scanners are expected to provide more accurate information about the localization of SNs. OBJECTIVE: To assess the role of combined SPECT-CT in SN identification in the clinically negative neck of patients with OSCC. MATERIALS AND METHODS: Lymphoscintigraphy comprising planar and SPECT-CT acquisition was performed in 34 consecutive patients with OSCC stage I and II (T1-2N0M0) prior to sentinel node biopsy (SNB) and selective neck dissection. The number of SNs and anatomical location was recorded according to lymphoscintigraphy and operative findings. RESULTS: SNB was conducted in 33 patients. SNs were identified in 94% (32/34) of the patients using SPECT-CT. In 91% (29/32) of the patients SNs were harvested from all of the levels involved on SPECT-CT. SPECT-CT imaging demonstrated extra SNs compared with planar lymphoscintigraphic imaging in 47% (15/32) of patients. In seven cases the anatomical level of SN according to SPECT-CT was reclassified during surgery. The overall incidence of lymph node metastases was 19% (6/32). There were no false negative SNs.

U2 - 10.1080/00016480600794453

DO - 10.1080/00016480600794453

M3 - Journal article

C2 - 16923717

SN - 0001-6489

VL - 126

SP - 1096

EP - 1103

JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

IS - 10

ER -