The structure of the serotonin system: A PET imaging study

Vincent Beliveau; Brice Ozenne; Stephen Strother; Douglas N. Greve; Claus Svarer; Gitte Moos Knudsen; Melanie Ganz

doi:10.1016/j.neuroimage.2019.116240

The structure of the serotonin system: A PET imaging study

Vincent Beliveau, Brice Ozenne, Stephen Strother, Douglas N. Greve, Claus Svarer, Gitte Moos Knudsen, Melanie Ganz^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

23 Citationer (Scopus)

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Abstract

The human brain atlas of the serotonin (5-HT) system does not conform with commonly used parcellations of neocortex, since the spatial distribution of homogeneous 5-HT receptors and transporter is not aligned with such brain regions. This discrepancy indicates that a neocortical parcellation specific to the 5-HT system is needed. We first outline issues with an existing parcellation of the 5-HT system, and present an alternative parcellation derived from brain MR- and high-resolution PET images of five different 5-HT targets from 210 healthy controls. We then explore how well this new 5-HT parcellation can explain mRNA levels of all 5-HT genes. The parcellation derived here represents a characterization of the 5-HT system which is more stable and explains the underlying 5-HT molecular imaging data better than other atlases, and may hence be more sensitive to capture region-specific changes modulated by 5-HT.

Originalsprog	Engelsk
Artikelnummer	116240
Tidsskrift	NeuroImage
Vol/bind	205
ISSN	1053-8119
DOI	https://doi.org/10.1016/j.neuroimage.2019.116240
Status	Udgivet - 2020

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10.1016/j.neuroimage.2019.116240Licens: CC BY-NC-ND

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abstract = "The human brain atlas of the serotonin (5-HT) system does not conform with commonly used parcellations of neocortex, since the spatial distribution of homogeneous 5-HT receptors and transporter is not aligned with such brain regions. This discrepancy indicates that a neocortical parcellation specific to the 5-HT system is needed. We first outline issues with an existing parcellation of the 5-HT system, and present an alternative parcellation derived from brain MR- and high-resolution PET images of five different 5-HT targets from 210 healthy controls. We then explore how well this new 5-HT parcellation can explain mRNA levels of all 5-HT genes. The parcellation derived here represents a characterization of the 5-HT system which is more stable and explains the underlying 5-HT molecular imaging data better than other atlases, and may hence be more sensitive to capture region-specific changes modulated by 5-HT.",

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AU - Ozenne, Brice

AU - Strother, Stephen

AU - Greve, Douglas N.

AU - Svarer, Claus

AU - Knudsen, Gitte Moos

AU - Ganz, Melanie

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