The Swedish National Facility for Magnetoencephalography Parkinson's Disease Dataset (v1.1)

Parkinson's disease (PD) is characterised by a loss of dopamine and dopaminergic cells. The consequences hereof are widespread network disturbances in brain function. It is still an ongoing topic of investigation how these disease-related changes in brain function manifest in PD relate to clinical symptoms in the motor-, cognitive-, and emotional domains. We present The Swedish National Facility for Magnetoencephalography Parkinson's Disease Dataset (NatMEG-PD) as an Open Science contribution to identify the functional neural signatures of Parkinson's disease and contribute to diagnosis and treatment. The dataset consists of whole-head magnetoencephalographic (MEG) recordings from 66 well-characterized PD patients and 68 age- and sex-matched healthy controls. NatMEG-PD was acquired for investigating beta-band activity and contains resting-state MEG, MEG during an active movement task, and MEG during passive movements. The data includes anonymised MRI for source analysis and clinical scores for motor, cognitive and depressive symptoms. MEG data is rich in nature and can be used to explore numerous kinds of functional brain changes in PD. By sharing these data, we hope other researchers will contribute to advancing our understanding of the relationship between brain activity and disease state or symptoms.