The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations

Majken K Jensen; Eric B Rimm; Kenneth J Mukamal; Andrew C Edmondson; Daniel J Rader; Ulla Vogel; Anne Tjønneland; Thorkild I A Sørensen; Erik B Schmidt; Kim Overvad

doi:10.1093/eurheartj/ehp145

The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations

Majken K Jensen, Eric B Rimm, Kenneth J Mukamal, Andrew C Edmondson, Daniel J Rader, Ulla Vogel, Anne Tjønneland, Thorkild I A Sørensen, Erik B Schmidt, Kim Overvad

Institut for Folkesundhedsvidenskab

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

37 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Jul

Originalsprog	Engelsk
Tidsskrift	European Heart Journal
Vol/bind	30
Udgave nummer	13
Sider (fra-til)	1584-9
Antal sider	6
ISSN	0195-668X
DOI	https://doi.org/10.1093/eurheartj/ehp145
Status	Udgivet - 2009

Bibliografisk note

Keywords: Adult; Aged; Case-Control Studies; Cholesterol, HDL; Coronary Disease; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Lipase; Lipids; Male; Middle Aged; Risk Factors

Adgang til dokumentet

10.1093/eurheartj/ehp145

Citationsformater

The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations. / Jensen, Majken K; Rimm, Eric B; Mukamal, Kenneth J; Edmondson, Andrew C; Rader, Daniel J; Vogel, Ulla; Tjønneland, Anne; Sørensen, Thorkild I A; Schmidt, Erik B; Overvad, Kim.

I: European Heart Journal, Bind 30, Nr. 13, 2009, s. 1584-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

@article{cf54d8507e0311df928f000ea68e967b,

title = "The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations",

abstract = "AIMS: Endothelial lipase (LIPG) is implicated in the metabolism of high-density lipoprotein cholesterol (HDL-C). Small studies in selected populations have reported higher HDL-C levels among carriers of the common T111I variant in LIPG, but whether this variant is associated with plasma lipids and risk of coronary heart disease (CHD) in the general population is unclear. The objective of this study was to address the associations of the T111I variant with plasma lipids and risk of CHD in three independent prospective studies of generally healthy men and women. METHODS AND RESULTS: The T111I variant was genotyped in case-control studies of CHD nested within the Diet, Cancer, and Health study with 998 cases, Nurses' Health Study with 241 cases, and Health Professionals Follow-up Study with 262 cases. The minor allele frequency in the combined pool of controls was 0.29. The T111I variant was not associated with HDL-C or any other lipid and lipoprotein measures. Compared with wildtype homozygotes, the pooled estimate for risk of CHD was 0.95 (0.85-1.06) per T111I allele. CONCLUSION: Our analysis among healthy Caucasian men and women from three independent studies does not support an association between the T111I variant and HDL-C, other plasma lipids, or risk of CHD.",

author = "Jensen, {Majken K} and Rimm, {Eric B} and Mukamal, {Kenneth J} and Edmondson, {Andrew C} and Rader, {Daniel J} and Ulla Vogel and Anne Tj{\o}nneland and S{\o}rensen, {Thorkild I A} and Schmidt, {Erik B} and Kim Overvad",

note = "Keywords: Adult; Aged; Case-Control Studies; Cholesterol, HDL; Coronary Disease; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Lipase; Lipids; Male; Middle Aged; Risk Factors",

year = "2009",

doi = "10.1093/eurheartj/ehp145",

language = "English",

volume = "30",

pages = "1584--9",

journal = "European Heart Journal",

issn = "0195-668X",

publisher = "Oxford University Press",

number = "13",

}

TY - JOUR

T1 - The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations

AU - Jensen, Majken K

AU - Rimm, Eric B

AU - Mukamal, Kenneth J

AU - Edmondson, Andrew C

AU - Rader, Daniel J

AU - Vogel, Ulla

AU - Tjønneland, Anne

AU - Sørensen, Thorkild I A

AU - Schmidt, Erik B

AU - Overvad, Kim

N1 - Keywords: Adult; Aged; Case-Control Studies; Cholesterol, HDL; Coronary Disease; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Lipase; Lipids; Male; Middle Aged; Risk Factors

PY - 2009

Y1 - 2009

N2 - AIMS: Endothelial lipase (LIPG) is implicated in the metabolism of high-density lipoprotein cholesterol (HDL-C). Small studies in selected populations have reported higher HDL-C levels among carriers of the common T111I variant in LIPG, but whether this variant is associated with plasma lipids and risk of coronary heart disease (CHD) in the general population is unclear. The objective of this study was to address the associations of the T111I variant with plasma lipids and risk of CHD in three independent prospective studies of generally healthy men and women. METHODS AND RESULTS: The T111I variant was genotyped in case-control studies of CHD nested within the Diet, Cancer, and Health study with 998 cases, Nurses' Health Study with 241 cases, and Health Professionals Follow-up Study with 262 cases. The minor allele frequency in the combined pool of controls was 0.29. The T111I variant was not associated with HDL-C or any other lipid and lipoprotein measures. Compared with wildtype homozygotes, the pooled estimate for risk of CHD was 0.95 (0.85-1.06) per T111I allele. CONCLUSION: Our analysis among healthy Caucasian men and women from three independent studies does not support an association between the T111I variant and HDL-C, other plasma lipids, or risk of CHD.

AB - AIMS: Endothelial lipase (LIPG) is implicated in the metabolism of high-density lipoprotein cholesterol (HDL-C). Small studies in selected populations have reported higher HDL-C levels among carriers of the common T111I variant in LIPG, but whether this variant is associated with plasma lipids and risk of coronary heart disease (CHD) in the general population is unclear. The objective of this study was to address the associations of the T111I variant with plasma lipids and risk of CHD in three independent prospective studies of generally healthy men and women. METHODS AND RESULTS: The T111I variant was genotyped in case-control studies of CHD nested within the Diet, Cancer, and Health study with 998 cases, Nurses' Health Study with 241 cases, and Health Professionals Follow-up Study with 262 cases. The minor allele frequency in the combined pool of controls was 0.29. The T111I variant was not associated with HDL-C or any other lipid and lipoprotein measures. Compared with wildtype homozygotes, the pooled estimate for risk of CHD was 0.95 (0.85-1.06) per T111I allele. CONCLUSION: Our analysis among healthy Caucasian men and women from three independent studies does not support an association between the T111I variant and HDL-C, other plasma lipids, or risk of CHD.

U2 - 10.1093/eurheartj/ehp145

DO - 10.1093/eurheartj/ehp145

M3 - Journal article

C2 - 19411665

VL - 30

SP - 1584

EP - 1589

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 13

ER -