The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells

André Brannvoll, Xiaoyu Xue, Youngho Kwon, Smaragdi Kompocholi, Anne Katrine W. Simonsen, Keerthana S. Viswalingam, Leticia Gonzalez, Ian D. Hickson, Vibe H. Oestergaard, Hocine W. Mankouri, Patrick Sung, Michael Lisby*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

11 Citationer (Scopus)
146 Downloads (Pure)

Abstract

DNA helicases are important for DNA repair processes. Here, Brannvoll et al. show that ZGRF1 is a 5′-to-3′ DNA helicase that promotes the resolution of replication-blocking DNA lesions by homologous recombination. ZGRF1 is recruited to sites of DNA damage and directly stimulates the RAD51 recombinase.

OriginalsprogEngelsk
Artikelnummer107849
TidsskriftCell Reports
Vol/bind32
Udgave nummer1
Antal sider25
ISSN2211-1247
DOI
StatusUdgivet - 2020

Citationsformater