Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | European Journal of Endocrinology |
| Vol/bind | 161 |
| Udgave nummer | 3 |
| Sider (fra-til) | 475-81 |
| Antal sider | 7 |
| ISSN | 0804-4643 |
| DOI | |
| Status | Udgivet - 2009 |
Bibliografisk note
Keywords: Adolescent; Adult; Aged; Biological Markers; Cross-Sectional Studies; Deficiency Diseases; Denmark; Female; Humans; Iodine; Male; Middle Aged; Nutritional Status; Population; Prevalence; Prognosis; Thyroglobulin; Young AdultAdgang til dokumentet
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Thyroglobulin as a marker of iodine nutrition status in the general population. / Vejbjerg, Pernille; Knudsen, Nils; Perrild, Hans; Laurberg, Peter; Carlé, Allan; Pedersen, Inge Bülow; Rasmussen, Lone B; Ovesen, Lars; Jørgensen, Torben.
I: European Journal of Endocrinology, Bind 161, Nr. 3, 2009, s. 475-81.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Thyroglobulin as a marker of iodine nutrition status in the general population
AU - Vejbjerg, Pernille
AU - Knudsen, Nils
AU - Perrild, Hans
AU - Laurberg, Peter
AU - Carlé, Allan
AU - Pedersen, Inge Bülow
AU - Rasmussen, Lone B
AU - Ovesen, Lars
AU - Jørgensen, Torben
N1 - Keywords: Adolescent; Adult; Aged; Biological Markers; Cross-Sectional Studies; Deficiency Diseases; Denmark; Female; Humans; Iodine; Male; Middle Aged; Nutritional Status; Population; Prevalence; Prognosis; Thyroglobulin; Young Adult
PY - 2009
Y1 - 2009
N2 - OBJECTIVE: The iodine status of a population is traditionally evaluated by either urinary iodine (UI) excretion or by some measure of thyroid volume and the prevalence of goitre. In this prospective study of a mandatory iodization programme, we aimed to evaluate serum thyroglobulin (Tg) as a marker of iodine status in the population. METHODS: Two identical cross-sectional studies were performed before (1997-1998, n=4649) and after (2004-2005, n=3570) the initiation of the Danish iodization programme in two areas with mild and moderate iodine deficiency. Serum Tg was measured from blood samples. Thyroid volume was measured by ultrasonography. RESULTS: Before iodization, the median serum Tg was considerably higher in moderate than in mild iodine deficiency. Iodization led to a lower serum Tg in all examined age groups. The marked pre-iodization difference in Tg level between the regions was eliminated. The prevalence of Tg above the suggested reference limit (40 microg/l) decreased from 11.3 to 3.7% (P<0.0001). Using bootstrapping, we demonstrated a higher efficacy of Tg than of thyroid volume to show a difference between pre- and post-iodization values. CONCLUSION: We found serum Tg to be a suitable marker of iodine nutrition status in the population. The results may suggest that the Danish iodization programme has led to a sufficient iodine intake, even if the median UI excretion is still marginally low according to WHO criteria.
AB - OBJECTIVE: The iodine status of a population is traditionally evaluated by either urinary iodine (UI) excretion or by some measure of thyroid volume and the prevalence of goitre. In this prospective study of a mandatory iodization programme, we aimed to evaluate serum thyroglobulin (Tg) as a marker of iodine status in the population. METHODS: Two identical cross-sectional studies were performed before (1997-1998, n=4649) and after (2004-2005, n=3570) the initiation of the Danish iodization programme in two areas with mild and moderate iodine deficiency. Serum Tg was measured from blood samples. Thyroid volume was measured by ultrasonography. RESULTS: Before iodization, the median serum Tg was considerably higher in moderate than in mild iodine deficiency. Iodization led to a lower serum Tg in all examined age groups. The marked pre-iodization difference in Tg level between the regions was eliminated. The prevalence of Tg above the suggested reference limit (40 microg/l) decreased from 11.3 to 3.7% (P<0.0001). Using bootstrapping, we demonstrated a higher efficacy of Tg than of thyroid volume to show a difference between pre- and post-iodization values. CONCLUSION: We found serum Tg to be a suitable marker of iodine nutrition status in the population. The results may suggest that the Danish iodization programme has led to a sufficient iodine intake, even if the median UI excretion is still marginally low according to WHO criteria.
U2 - 10.1530/EJE-09-0262
DO - 10.1530/EJE-09-0262
M3 - Journal article
C2 - 19556382
VL - 161
SP - 475
EP - 481
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 3
ER -