TY - JOUR
T1 - TIP60 in aging and neurodegeneration
AU - Li, Zhiquan
AU - Rasmussen, Lene Juel
PY - 2020
Y1 - 2020
N2 - Epigenetic modification of chromatin, including histone methylation and acetylation, plays critical roles in eukaryotic cells and has a significant impact on chromatin structure/accessibility, gene regulation and, susceptibility to aging, neurodegenerative disease, cancer, and other age-related diseases. This article reviews the current advances on TIP60/KAT5, a major histone acetyltransferase with diverse functions in eukaryotes, with emphasis on its regulation of autophagy, proteasome-dependent protein turnover, RNA transcription, DNA repair, circadian rhythms, learning and memory, and other neurological functions implicated in aging and neurodegeneration. Moreover, the promising therapeutic potential of TIP60 is discussed to target Alzheimer's disease and other neurological diseases.
AB - Epigenetic modification of chromatin, including histone methylation and acetylation, plays critical roles in eukaryotic cells and has a significant impact on chromatin structure/accessibility, gene regulation and, susceptibility to aging, neurodegenerative disease, cancer, and other age-related diseases. This article reviews the current advances on TIP60/KAT5, a major histone acetyltransferase with diverse functions in eukaryotes, with emphasis on its regulation of autophagy, proteasome-dependent protein turnover, RNA transcription, DNA repair, circadian rhythms, learning and memory, and other neurological functions implicated in aging and neurodegeneration. Moreover, the promising therapeutic potential of TIP60 is discussed to target Alzheimer's disease and other neurological diseases.
KW - Acetylation
KW - Alzheimer's disease
KW - Autophagy
KW - Gene expression
KW - Genome instability
KW - Memory
U2 - 10.1016/j.arr.2020.101195
DO - 10.1016/j.arr.2020.101195
M3 - Review
C2 - 33091598
AN - SCOPUS:85096172039
SN - 1568-1637
VL - 64
JO - Ageing Research Reviews
JF - Ageing Research Reviews
M1 - 101195
ER -