TOPping up ATR activity

Jiri Bartek; Niels Mailand

doi:10.1016/j.cell.2006.02.029

TOPping up ATR activity

Jiri Bartek, Niels Mailand

Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › peer review

12 Citationer (Scopus)

Abstract

The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity.

Originalsprog	Engelsk
Tidsskrift	Cell
Vol/bind	124
Udgave nummer	5
Sider (fra-til)	888-90
Antal sider	3
ISSN	0092-8674
DOI	https://doi.org/10.1016/j.cell.2006.02.029
Status	Udgivet - 10 mar. 2006
Udgivet eksternt	Ja

Adgang til dokumentet

10.1016/j.cell.2006.02.029

Citationsformater

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title = "TOPping up ATR activity",

abstract = "The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity.",

keywords = "Animals, Ataxia Telangiectasia Mutated Proteins, Carrier Proteins, Cell Cycle Proteins, DNA Repair, DNA-Binding Proteins, Enzyme Activation, Gene Expression Regulation, Humans, Models, Genetic, Nuclear Proteins, Protein-Serine-Threonine Kinases, Xenopus Proteins",

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AU - Mailand, Niels

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AB - The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity.

KW - Animals

KW - Ataxia Telangiectasia Mutated Proteins

KW - Carrier Proteins

KW - Cell Cycle Proteins

KW - DNA Repair

KW - DNA-Binding Proteins

KW - Enzyme Activation

KW - Gene Expression Regulation

KW - Humans

KW - Models, Genetic

KW - Nuclear Proteins

KW - Protein-Serine-Threonine Kinases

KW - Xenopus Proteins

U2 - 10.1016/j.cell.2006.02.029

DO - 10.1016/j.cell.2006.02.029

M3 - Comment/debate

C2 - 16530035

VL - 124

SP - 888

EP - 890

JO - Cell

JF - Cell

SN - 0092-8674

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