TY - JOUR
T1 - Total and cause-specific mortality by elevated transferrin saturation and hemochromatosis genotype in individuals with diabetes - two general population studies
AU - Ellervik, Christina
AU - Mandrup-Poulsen, Thomas
AU - Tybjærg-Hansen, Anne
AU - Nordestgaard, Børge G
PY - 2013/10/15
Y1 - 2013/10/15
N2 - ObjectiveMortality is increased in patients with hereditary hemochromatosis, in individuals from the general population with increased transferrin saturation(TS), and also in patients with diabetes type 1 and increased TS from a highly specialised diabetes clinic. Thus, we have recommended targeted screening for TS in specialised diabetes clinics. Whether mortality is also increased in individuals ascertained from the general population with diabetes and increased TS is unknown.Research design and methodsIn two Danish population studies(N=84,865), we examined mortality according to baseline TS and hemochromatosis genotype(HFE) C282Y/C282Y in individuals with diabetes(type 1,N=118;type 2,N=3228;total,N=3346).ResultsThe cumulative survival was reduced in individuals with diabetes with TS≥50% vs.
AB - ObjectiveMortality is increased in patients with hereditary hemochromatosis, in individuals from the general population with increased transferrin saturation(TS), and also in patients with diabetes type 1 and increased TS from a highly specialised diabetes clinic. Thus, we have recommended targeted screening for TS in specialised diabetes clinics. Whether mortality is also increased in individuals ascertained from the general population with diabetes and increased TS is unknown.Research design and methodsIn two Danish population studies(N=84,865), we examined mortality according to baseline TS and hemochromatosis genotype(HFE) C282Y/C282Y in individuals with diabetes(type 1,N=118;type 2,N=3228;total,N=3346).ResultsThe cumulative survival was reduced in individuals with diabetes with TS≥50% vs.
U2 - 10.2337/dc13-1198
DO - 10.2337/dc13-1198
M3 - Journal article
C2 - 24130348
VL - 37
SP - 444
EP - 452
JO - Diabetes Care
JF - Diabetes Care
SN - 0149-5992
IS - 2
ER -