Toward a Concept of Stretch Coupling in Smooth Muscle: A Thesis by Lars Thuneberg on Contractile Activity in Neonatal Interstitial Cells of Cajal

Jan D Huizinga; Wim J E P Lammers; Hanne B Mikkelsen; Yaohui Zhu; Xuan-Yu Wang

doi:10.1002/ar.21214

Toward a Concept of Stretch Coupling in Smooth Muscle: A Thesis by Lars Thuneberg on Contractile Activity in Neonatal Interstitial Cells of Cajal

Jan D Huizinga, Wim J E P Lammers, Hanne B Mikkelsen, Yaohui Zhu, Xuan-Yu Wang

Institut for Cellulær og Molekylær Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

10 Citationer (Scopus)

Abstract

Udgivelsesdato: 2010-Aug-4

Originalsprog	Engelsk
Tidsskrift	Anatomical Record
Vol/bind	293
Udgave nummer	9
Sider (fra-til)	1543-1552
Antal sider	10
ISSN	0003-276X
DOI	https://doi.org/10.1002/ar.21214
Status	Udgivet - sep. 2010

Adgang til dokumentet

10.1002/ar.21214

Citationsformater

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title = "Toward a Concept of Stretch Coupling in Smooth Muscle: A Thesis by Lars Thuneberg on Contractile Activity in Neonatal Interstitial Cells of Cajal",

abstract = "The hypothesis was put forward by Thuneberg that rhythmically contracting interstitial cells of Cajal (ICC) were sensing stretch of the musculature and that this information was transmitted to smooth muscle cells via peg and socket contacts. The present study provides the evidence for the contractile nature of ICC as perceived by Thuneberg. The contractile activity is shown by video frame subtraction and by tracking areas of interest in sequential video frames. Thuneberg used neonatal ICC in culture maintained between two coverslips thereby allowing growth factors to quickly reach optimal concentrations. Contractions of ICC were seen to precede smooth muscle contractions. In addition, strong contractions were observed solely in branches of ICC. It is hoped that this communication will stimulate discussion about the contractile nature of ICC and that this phenomenon will eventually find its place amongst the physiological properties of the ICC networks of the gut musculature. Anat Rec, 2010. (c) 2010 Wiley-Liss, Inc.",

author = "Huizinga, {Jan D} and Lammers, {Wim J E P} and Mikkelsen, {Hanne B} and Yaohui Zhu and Xuan-Yu Wang",

year = "2010",

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doi = "10.1002/ar.21214",

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T1 - Toward a Concept of Stretch Coupling in Smooth Muscle: A Thesis by Lars Thuneberg on Contractile Activity in Neonatal Interstitial Cells of Cajal

AU - Huizinga, Jan D

AU - Lammers, Wim J E P

AU - Mikkelsen, Hanne B

AU - Zhu, Yaohui

AU - Wang, Xuan-Yu

PY - 2010/9

Y1 - 2010/9

N2 - The hypothesis was put forward by Thuneberg that rhythmically contracting interstitial cells of Cajal (ICC) were sensing stretch of the musculature and that this information was transmitted to smooth muscle cells via peg and socket contacts. The present study provides the evidence for the contractile nature of ICC as perceived by Thuneberg. The contractile activity is shown by video frame subtraction and by tracking areas of interest in sequential video frames. Thuneberg used neonatal ICC in culture maintained between two coverslips thereby allowing growth factors to quickly reach optimal concentrations. Contractions of ICC were seen to precede smooth muscle contractions. In addition, strong contractions were observed solely in branches of ICC. It is hoped that this communication will stimulate discussion about the contractile nature of ICC and that this phenomenon will eventually find its place amongst the physiological properties of the ICC networks of the gut musculature. Anat Rec, 2010. (c) 2010 Wiley-Liss, Inc.

AB - The hypothesis was put forward by Thuneberg that rhythmically contracting interstitial cells of Cajal (ICC) were sensing stretch of the musculature and that this information was transmitted to smooth muscle cells via peg and socket contacts. The present study provides the evidence for the contractile nature of ICC as perceived by Thuneberg. The contractile activity is shown by video frame subtraction and by tracking areas of interest in sequential video frames. Thuneberg used neonatal ICC in culture maintained between two coverslips thereby allowing growth factors to quickly reach optimal concentrations. Contractions of ICC were seen to precede smooth muscle contractions. In addition, strong contractions were observed solely in branches of ICC. It is hoped that this communication will stimulate discussion about the contractile nature of ICC and that this phenomenon will eventually find its place amongst the physiological properties of the ICC networks of the gut musculature. Anat Rec, 2010. (c) 2010 Wiley-Liss, Inc.

U2 - 10.1002/ar.21214

DO - 10.1002/ar.21214

M3 - Journal article

C2 - 20687173

SN - 0003-276X

VL - 293

SP - 1543

EP - 1552

JO - Anatomical Record

JF - Anatomical Record

IS - 9

ER -