Abstract
Horse domestication revolutionized warfare and accelerated travel, trade, and the geographic expansion of languages. Here, we present the largest DNA time series for a non-human organism to date, including genome-scale data from 149 ancient animals and 129 ancient genomes (≥1-fold coverage), 87 of which are new. This extensive dataset allows us to assess the modern legacy of past equestrian civilizations. We find that two extinct horse lineages existed during early domestication, one at the far western (Iberia) and the other at the far eastern range (Siberia) of Eurasia. None of these contributed significantly to modern diversity. We show that the influence of Persian-related horse lineages increased following the Islamic conquests in Europe and Asia. Multiple alleles associated with elite-racing, including at the MSTN “speed gene,” only rose in popularity within the last millennium. Finally, the development of modern breeding impacted genetic diversity more dramatically than the previous millennia of human management. Genome-wide data from 278 ancient equids provide insights into how ancient equestrian civilizations managed, exchanged, and bred horses and indicate vast loss of genetic diversity as well as the existence of two extinct lineages of horses that failed to contribute to modern domestic animals.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Cell |
| Vol/bind | 177 |
| Udgave nummer | 6 |
| Sider (fra-til) | 1419-1435, e1-e31 |
| ISSN | 0092-8674 |
| DOI | |
| Status | Udgivet - 2019 |
Adgang til dokumentet
- Tracking Five Millennia of Horse Management with Extensive Ancient Genome Time SeriesForlagets udgivne version, 4,5 MBLicens: CC BY-NC-ND
Citationsformater
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
Tracking Five Millennia of Horse Management with Extensive Ancient Genome Time Series. / Fages, Antoine; Hanghøj, Kristian; Khan, Naveed; Gaunitz, Charleen; Seguin-Orlando, Andaine; Leonardi, Michela; McCrory Constantz, Christian; Gamba, Cristina; Al-Rasheid, Khaled A.S.; Albizuri, Silvia; Alfarhan, Ahmed H.; Allentoft, Morten; Alquraishi, Saleh; Anthony, David; Baimukhanov, Nurbol; Barrett, James H.; Bayarsaikhan, Jamsranjav; Benecke, Norbert; Bernáldez-Sánchez, Eloísa; Berrocal-Rangel, Luis; Biglari, Fereidoun; Boessenkool, Sanne; Boldgiv, Bazartseren; Brem, Gottfried; Brown, Dorcas; Burger, Joachim; Crubézy, Eric; Daugnora, Linas; Davoudi, Hossein; Damgaard, Peter de Barros; de los Ángeles de Chorro y de Villa-Ceballos, María; Deschler-Erb, Sabine; Detry, Cleia; Dill, Nadine; do Mar Oom, Maria; Dohr, Anna; Ellingvåg, Sturla; Erdenebaatar, Diimaajav; Fathi, Homa; Felkel, Sabine; Fernández-Rodríguez, Carlos; García-Viñas, Esteban; Germonpré, Mietje; Granado, José D.; Hallsson, Jón H.; Hemmer, Helmut; Hofreiter, Michael; Kasparov, Aleksei; Khasanov, Mutalib; Khazaeli, Roya; Kosintsev, Pavel; Kristiansen, Kristian; Kubatbek, Tabaldiev; Kuderna, Lukas; Kuznetsov, Pavel; Laleh, Haeedeh; Leonard, Jennifer A.; Lhuillier, Johanna; Liesau von Lettow-Vorbeck, Corina; Logvin, Andrey; Lõugas, Lembi; Ludwig, Arne; Luis, Cristina; Arruda, Ana Margarida; Marques-Bonet, Tomas; Matoso Silva, Raquel; Merz, Victor; Mijiddorj, Enkhbayar; Miller, Bryan K.; Monchalov, Oleg; Mohaseb, Fatemeh A.; Morales, Arturo; Nieto-Espinet, Ariadna; Nistelberger, Heidi; Onar, Vedat; Pálsdóttir, Albína H.; Pitulko, Vladimir; Pitskhelauri, Konstantin; Pruvost, Mélanie; Rajic Sikanjic, Petra; Rapan Papeša, Anita; Roslyakova, Natalia; Sardari, Alireza; Sauer, Eberhard; Schafberg, Renate; Scheu, Amelie; Schibler, Jörg; Schlumbaum, Angela; Serrand, Nathalie; Serres-Armero, Aitor; Shapiro, Beth; Sheikhi Seno, Shiva; Shevnina, Irina; Shidrang, Sonia; Southon, John; Star, Bastiaan; Sykes, Naomi; Taheri, Kamal; Taylor, William; Teegen, Wolf Rüdiger; Trbojević Vukičević, Tajana; Trixl, Simon; Tumen, Dashzeveg; Undrakhbold, Sainbileg; Usmanova, Emma; Vahdati, Ali; Valenzuela-Lamas, Silvia; Viegas, Catarina; Wallner, Barbara; Weinstock, Jaco; Zaibert, Victor; Clavel, Benoit; Lepetz, Sébastien; Mashkour, Marjan; Helgason, Agnar; Stefánsson, Kári; Barrey, Eric; Willerslev, Eske; Outram, Alan K.; Librado, Pablo; Orlando, Ludovic.
I: Cell, Bind 177, Nr. 6, 2019, s. 1419-1435, e1-e31.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
}
TY - JOUR
T1 - Tracking Five Millennia of Horse Management with Extensive Ancient Genome Time Series
AU - Fages, Antoine
AU - Hanghøj, Kristian
AU - Khan, Naveed
AU - Gaunitz, Charleen
AU - Seguin-Orlando, Andaine
AU - Leonardi, Michela
AU - McCrory Constantz, Christian
AU - Gamba, Cristina
AU - Al-Rasheid, Khaled A.S.
AU - Albizuri, Silvia
AU - Alfarhan, Ahmed H.
AU - Allentoft, Morten
AU - Alquraishi, Saleh
AU - Anthony, David
AU - Baimukhanov, Nurbol
AU - Barrett, James H.
AU - Bayarsaikhan, Jamsranjav
AU - Benecke, Norbert
AU - Bernáldez-Sánchez, Eloísa
AU - Berrocal-Rangel, Luis
AU - Biglari, Fereidoun
AU - Boessenkool, Sanne
AU - Boldgiv, Bazartseren
AU - Brem, Gottfried
AU - Brown, Dorcas
AU - Burger, Joachim
AU - Crubézy, Eric
AU - Daugnora, Linas
AU - Davoudi, Hossein
AU - Damgaard, Peter de Barros
AU - de los Ángeles de Chorro y de Villa-Ceballos, María
AU - Deschler-Erb, Sabine
AU - Detry, Cleia
AU - Dill, Nadine
AU - do Mar Oom, Maria
AU - Dohr, Anna
AU - Ellingvåg, Sturla
AU - Erdenebaatar, Diimaajav
AU - Fathi, Homa
AU - Felkel, Sabine
AU - Fernández-Rodríguez, Carlos
AU - García-Viñas, Esteban
AU - Germonpré, Mietje
AU - Granado, José D.
AU - Hallsson, Jón H.
AU - Hemmer, Helmut
AU - Hofreiter, Michael
AU - Kasparov, Aleksei
AU - Khasanov, Mutalib
AU - Khazaeli, Roya
AU - Kosintsev, Pavel
AU - Kristiansen, Kristian
AU - Kubatbek, Tabaldiev
AU - Kuderna, Lukas
AU - Kuznetsov, Pavel
AU - Laleh, Haeedeh
AU - Leonard, Jennifer A.
AU - Lhuillier, Johanna
AU - Liesau von Lettow-Vorbeck, Corina
AU - Logvin, Andrey
AU - Lõugas, Lembi
AU - Ludwig, Arne
AU - Luis, Cristina
AU - Arruda, Ana Margarida
AU - Marques-Bonet, Tomas
AU - Matoso Silva, Raquel
AU - Merz, Victor
AU - Mijiddorj, Enkhbayar
AU - Miller, Bryan K.
AU - Monchalov, Oleg
AU - Mohaseb, Fatemeh A.
AU - Morales, Arturo
AU - Nieto-Espinet, Ariadna
AU - Nistelberger, Heidi
AU - Onar, Vedat
AU - Pálsdóttir, Albína H.
AU - Pitulko, Vladimir
AU - Pitskhelauri, Konstantin
AU - Pruvost, Mélanie
AU - Rajic Sikanjic, Petra
AU - Rapan Papeša, Anita
AU - Roslyakova, Natalia
AU - Sardari, Alireza
AU - Sauer, Eberhard
AU - Schafberg, Renate
AU - Scheu, Amelie
AU - Schibler, Jörg
AU - Schlumbaum, Angela
AU - Serrand, Nathalie
AU - Serres-Armero, Aitor
AU - Shapiro, Beth
AU - Sheikhi Seno, Shiva
AU - Shevnina, Irina
AU - Shidrang, Sonia
AU - Southon, John
AU - Star, Bastiaan
AU - Sykes, Naomi
AU - Taheri, Kamal
AU - Taylor, William
AU - Teegen, Wolf Rüdiger
AU - Trbojević Vukičević, Tajana
AU - Trixl, Simon
AU - Tumen, Dashzeveg
AU - Undrakhbold, Sainbileg
AU - Usmanova, Emma
AU - Vahdati, Ali
AU - Valenzuela-Lamas, Silvia
AU - Viegas, Catarina
AU - Wallner, Barbara
AU - Weinstock, Jaco
AU - Zaibert, Victor
AU - Clavel, Benoit
AU - Lepetz, Sébastien
AU - Mashkour, Marjan
AU - Helgason, Agnar
AU - Stefánsson, Kári
AU - Barrey, Eric
AU - Willerslev, Eske
AU - Outram, Alan K.
AU - Librado, Pablo
AU - Orlando, Ludovic
PY - 2019
Y1 - 2019
N2 - Horse domestication revolutionized warfare and accelerated travel, trade, and the geographic expansion of languages. Here, we present the largest DNA time series for a non-human organism to date, including genome-scale data from 149 ancient animals and 129 ancient genomes (≥1-fold coverage), 87 of which are new. This extensive dataset allows us to assess the modern legacy of past equestrian civilizations. We find that two extinct horse lineages existed during early domestication, one at the far western (Iberia) and the other at the far eastern range (Siberia) of Eurasia. None of these contributed significantly to modern diversity. We show that the influence of Persian-related horse lineages increased following the Islamic conquests in Europe and Asia. Multiple alleles associated with elite-racing, including at the MSTN “speed gene,” only rose in popularity within the last millennium. Finally, the development of modern breeding impacted genetic diversity more dramatically than the previous millennia of human management. Genome-wide data from 278 ancient equids provide insights into how ancient equestrian civilizations managed, exchanged, and bred horses and indicate vast loss of genetic diversity as well as the existence of two extinct lineages of horses that failed to contribute to modern domestic animals.
AB - Horse domestication revolutionized warfare and accelerated travel, trade, and the geographic expansion of languages. Here, we present the largest DNA time series for a non-human organism to date, including genome-scale data from 149 ancient animals and 129 ancient genomes (≥1-fold coverage), 87 of which are new. This extensive dataset allows us to assess the modern legacy of past equestrian civilizations. We find that two extinct horse lineages existed during early domestication, one at the far western (Iberia) and the other at the far eastern range (Siberia) of Eurasia. None of these contributed significantly to modern diversity. We show that the influence of Persian-related horse lineages increased following the Islamic conquests in Europe and Asia. Multiple alleles associated with elite-racing, including at the MSTN “speed gene,” only rose in popularity within the last millennium. Finally, the development of modern breeding impacted genetic diversity more dramatically than the previous millennia of human management. Genome-wide data from 278 ancient equids provide insights into how ancient equestrian civilizations managed, exchanged, and bred horses and indicate vast loss of genetic diversity as well as the existence of two extinct lineages of horses that failed to contribute to modern domestic animals.
KW - ancient DNA
KW - animal breeding
KW - diversity
KW - domestication
KW - equestrian civilizations
KW - extinct lineages
KW - horses
KW - management
KW - mules
KW - selection
U2 - 10.1016/j.cell.2019.03.049
DO - 10.1016/j.cell.2019.03.049
M3 - Journal article
C2 - 31056281
AN - SCOPUS:85065780395
VL - 177
SP - 1419-1435, e1-e31
JO - Cell
JF - Cell
SN - 0092-8674
IS - 6
ER -