Transcutaneous blood gas monitoring and tissue perfusion during common femoral thromboendarterectomy

Emilie Sigvardt*, Søren Møller Rasmussen, Jonas Peter Eiberg, Helge Bjarup Dissing Sørensen, Christian Sylvest Meyhoff, Eske Kvanner Aasvang

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

9 Downloads (Pure)

Abstract

Background: Improving tissue perfusion can improve clinical outcomes in surgical patients, where monitoring may aid clinicians in detecting adverse conditions and guide interventions. Transcutaneous monitoring (TCM) of oxygen (tcpO2) and carbon dioxide (tcpCO2) is a well-proven technology and could potentially serve as a measure of local circulation, perfusion and metabolism, but the clinical use is not thoroughly explored. The purpose of this proof-of-concept study was to investigate whether TCM of blood gasses could detect changes in perfusion during major vascular surgery. Methods: Ten patients with peripheral arterial disease scheduled for lower limb major arterial revascularization under general anaesthesia were consecutively included. TcpO2 and tcpCO2 were continuously recorded from anaesthesia induction until skin closure with a TCM monitor placed on both legs and the thorax. Peripheral oxygen saturation was kept ≥94% and mean arterial blood pressure ≥65 mmHg. The primary outcomes were changes in tcpO2 and tcpCO2 related to arterial clamping and declamping during the procedure and analyzed by paired statistics. Results: Femoral artery clamping resulted in a significant decrease in tcpO2 (−2.1 kPa, IQR-4.2; −0.8), p=.017)), followed by a significant increase in response to arterial declamping (5.5 kPa, IQR 0–7.3), p=.017)). Arterial clamping resulted in a statistically significant increase in tcpCO2 (0.9 kPa, IQR 0.3–5.4), p=.008)) and a significant decrease following declamping (−0.7 kPa, IQR −2.6; −0.2), p=.011)). Conclusion: Transcutaneous monitoring of oxygen and carbon dioxide is a feasible method for detection of extreme changes in tissue perfusion during arterial clamping and declamping, and its use for improving patient outcomes should be explored. Clinical Trials identifier: NCT04040478. Registered on July 31, 2019.

OriginalsprogEngelsk
TidsskriftScandinavian Journal of Clinical and Laboratory Investigation
Vol/bind82
Udgave nummer4
Sider (fra-til)334-340
Antal sider7
ISSN0036-5513
DOI
StatusUdgivet - 2022

Bibliografisk note

Funding Information:
EKA: Indirect departmental research funding from Norpharma as well as lecture fees from Radiometer. CSM: Direct and indirect departmental research funding from Boehringer Ingelheim and Merck, Sharp & Dohme as well as lecture fees from Radiometer. HBDS: HBDS, EKA and CSM has co-founded a start-up company, WARD247 ApS, with the aim of pursuing the regulatory and commercial activities of the WARD-project (Wireless Assessment of Respiratory and circulatory Distress, a project developing a clinical support system for continuous wireless monitoring of vital signs). WARD247 ApS has obtained license agreement for any WARD-project software and patents. One patent has been filed: “Wireless Assessment of Respiratory and circulatory Distress (WARD) – Clinical Support System (CSS) – an automated clinical support system to improve patient safety and outcomes”. JPE: No relevant conflicts of interests. Other authors report: No conflicts of interests.

Publisher Copyright:
© 2022 Medisinsk Fysiologisk Forenings Forlag (MFFF).

Citationsformater