Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies

Nadeem Sarwar; Manjinder S Sandhu; Sally L Ricketts; Adam S Butterworth; Emanuele Di Angelantonio; S Matthijs Boekholdt; Willem Ouwehand; Hugh Watkins; Nilesh J Samani; Danish Saleheen; Debbie Lawlor; Muredach P Reilly; Aroon D Hingorani; Philippa J Talmud; John Danesh; Torben Jørgensen; Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration; Anne Tybjærg-Hansen; Ruth Frikke-Schmidt; Børge G. Nordestgaard

doi:10.1016/S0140-6736(10)60545-4

Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies

Nadeem Sarwar, Manjinder S Sandhu, Sally L Ricketts, Adam S Butterworth, Emanuele Di Angelantonio, S Matthijs Boekholdt, Willem Ouwehand, Hugh Watkins, Nilesh J Samani, Danish Saleheen, Debbie Lawlor, Muredach P Reilly, Aroon D Hingorani, Philippa J Talmud, John Danesh, Torben Jørgensen, Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration, Anne Tybjærg-Hansen, Ruth Frikke-Schmidt, Børge G. Nordestgaard

Institut for Folkesundhedsvidenskab

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

612 Citationer (Scopus)

Abstract

Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality.

Originalsprog	Engelsk
Tidsskrift	Lancet
Vol/bind	375
Udgave nummer	9726
Sider (fra-til)	1634-9
Antal sider	6
ISSN	0140-6736
DOI	https://doi.org/10.1016/S0140-6736(10)60545-4
Status	Udgivet - 8 maj 2010

Adgang til dokumentet

10.1016/S0140-6736(10)60545-4

Citationsformater

Sarwar, N., Sandhu, M. S., Ricketts, S. L., Butterworth, A. S., Di Angelantonio, E., Boekholdt, S. M., Ouwehand, W., Watkins, H., Samani, N. J., Saleheen, D., Lawlor, D., Reilly, M. P., Hingorani, A. D., Talmud, P. J., Danesh, J., Jørgensen, T., Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration, Tybjærg-Hansen, A., Frikke-Schmidt, R., & Nordestgaard, B. G. (2010). Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet, 375(9726), 1634-9. https://doi.org/10.1016/S0140-6736(10)60545-4

Sarwar, N, Sandhu, MS, Ricketts, SL, Butterworth, AS, Di Angelantonio, E, Boekholdt, SM, Ouwehand, W, Watkins, H, Samani, NJ, Saleheen, D, Lawlor, D, Reilly, MP, Hingorani, AD, Talmud, PJ, Danesh, J, Jørgensen, T, Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration, Tybjærg-Hansen, A, Frikke-Schmidt, R & Nordestgaard, BG 2010, 'Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies', Lancet, bind 375, nr. 9726, s. 1634-9. https://doi.org/10.1016/S0140-6736(10)60545-4

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title = "Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies",

abstract = "Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality.",

keywords = "Apolipoproteins, Apolipoproteins A, Coronary Disease, Gene Frequency, Genotype, Humans, Lipids, Lipoproteins, HDL, Lipoproteins, LDL, Lipoproteins, VLDL, Mendelian Randomization Analysis, Particle Size, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Risk Factors, Triglycerides",

author = "Nadeem Sarwar and Sandhu, {Manjinder S} and Ricketts, {Sally L} and Butterworth, {Adam S} and {Di Angelantonio}, Emanuele and Boekholdt, {S Matthijs} and Willem Ouwehand and Hugh Watkins and Samani, {Nilesh J} and Danish Saleheen and Debbie Lawlor and Reilly, {Muredach P} and Hingorani, {Aroon D} and Talmud, {Philippa J} and John Danesh and Torben J{\o}rgensen and Anne Tybj{\ae}rg-Hansen and Anne Tybj{\ae}rg-Hansen and Ruth Frikke-Schmidt and Nordestgaard, {B{\o}rge G.}",

year = "2010",

month = may,

day = "8",

doi = "10.1016/S0140-6736(10)60545-4",

language = "English",

volume = "375",

pages = "1634--9",

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TY - JOUR

T1 - Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies

AU - Sarwar, Nadeem

AU - Sandhu, Manjinder S

AU - Ricketts, Sally L

AU - Butterworth, Adam S

AU - Di Angelantonio, Emanuele

AU - Boekholdt, S Matthijs

AU - Ouwehand, Willem

AU - Watkins, Hugh

AU - Samani, Nilesh J

AU - Saleheen, Danish

AU - Lawlor, Debbie

AU - Reilly, Muredach P

AU - Hingorani, Aroon D

AU - Talmud, Philippa J

AU - Danesh, John

AU - Jørgensen, Torben

AU - Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration

AU - Tybjærg-Hansen, Anne

AU - Frikke-Schmidt, Ruth

AU - Nordestgaard, Børge G.

PY - 2010/5/8

Y1 - 2010/5/8

N2 - Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality.

AB - Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality.

KW - Apolipoproteins

KW - Apolipoproteins A

KW - Coronary Disease

KW - Gene Frequency

KW - Genotype

KW - Humans

KW - Lipids

KW - Lipoproteins, HDL

KW - Lipoproteins, LDL

KW - Lipoproteins, VLDL

KW - Mendelian Randomization Analysis

KW - Particle Size

KW - Polymorphism, Single Nucleotide

KW - Promoter Regions, Genetic

KW - Risk Factors

KW - Triglycerides

U2 - 10.1016/S0140-6736(10)60545-4

DO - 10.1016/S0140-6736(10)60545-4

M3 - Journal article

C2 - 20452521

SN - 0140-6736

VL - 375

SP - 1634

EP - 1639

JO - Lancet

JF - Lancet

IS - 9726

ER -