Two episodes of anaphylaxis following exposure to hydroxypropyl methylcellulose during cataract surgery

Sofie J. Munk; Steffen Heegaard; Holger Mosbech; Lene H Garvey

doi:10.1016/j.jcrs.2013.02.034

Two episodes of anaphylaxis following exposure to hydroxypropyl methylcellulose during cataract surgery

Sofie J. Munk, Steffen Heegaard, Holger Mosbech, Lene H Garvey

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

20 Citationer (Scopus)

Abstract

We report a case of immediate severe anaphylaxis to hydroxypropyl methylcellulose (HPMC) on 2 separate occasions during cataract surgery in a 71-year-old patient. Skin prick tests were positive for HPMC, a constituent of Ocucoat and Xylocaine gel, which were administered intraocularly during surgery. Skin prick tests were also positive for methylcellulose. Based on symptoms and clinical signs of anaphylaxis following 2 separate cataract operations together with positive prick tests to HPMC, HPMC is the most plausible cause of the reactions. The patient has since had uneventful surgery for a detached retina avoiding HPMC. This case stresses the importance of considering all medication given to patients as possible causes of an anaphylactic reaction.

Originalsprog	Engelsk
Tidsskrift	Journal of Cataract & Refractive Surgery
Vol/bind	39
Udgave nummer	6
Sider (fra-til)	948-951
ISSN	0886-3350
DOI	https://doi.org/10.1016/j.jcrs.2013.02.034
Status	Udgivet - 2013

Bibliografisk note

FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

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Citationsformater

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title = "Two episodes of anaphylaxis following exposure to hydroxypropyl methylcellulose during cataract surgery",

abstract = "We report a case of immediate severe anaphylaxis to hydroxypropyl methylcellulose (HPMC) on 2 separate occasions during cataract surgery in a 71-year-old patient. Skin prick tests were positive for HPMC, a constituent of Ocucoat and Xylocaine gel, which were administered intraocularly during surgery. Skin prick tests were also positive for methylcellulose. Based on symptoms and clinical signs of anaphylaxis following 2 separate cataract operations together with positive prick tests to HPMC, HPMC is the most plausible cause of the reactions. The patient has since had uneventful surgery for a detached retina avoiding HPMC. This case stresses the importance of considering all medication given to patients as possible causes of an anaphylactic reaction.",

keywords = "Aged, Anaphylaxis, Cataract Extraction, Drug Hypersensitivity, Humans, Male, Methylcellulose, Ophthalmic Solutions, Recurrence, Skin Tests",

author = "Munk, {Sofie J.} and Steffen Heegaard and Holger Mosbech and Garvey, {Lene H}",

note = "FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.",

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T1 - Two episodes of anaphylaxis following exposure to hydroxypropyl methylcellulose during cataract surgery

AU - Munk, Sofie J.

AU - Heegaard, Steffen

AU - Mosbech, Holger

AU - Garvey, Lene H

N1 - FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

PY - 2013

Y1 - 2013

N2 - We report a case of immediate severe anaphylaxis to hydroxypropyl methylcellulose (HPMC) on 2 separate occasions during cataract surgery in a 71-year-old patient. Skin prick tests were positive for HPMC, a constituent of Ocucoat and Xylocaine gel, which were administered intraocularly during surgery. Skin prick tests were also positive for methylcellulose. Based on symptoms and clinical signs of anaphylaxis following 2 separate cataract operations together with positive prick tests to HPMC, HPMC is the most plausible cause of the reactions. The patient has since had uneventful surgery for a detached retina avoiding HPMC. This case stresses the importance of considering all medication given to patients as possible causes of an anaphylactic reaction.

AB - We report a case of immediate severe anaphylaxis to hydroxypropyl methylcellulose (HPMC) on 2 separate occasions during cataract surgery in a 71-year-old patient. Skin prick tests were positive for HPMC, a constituent of Ocucoat and Xylocaine gel, which were administered intraocularly during surgery. Skin prick tests were also positive for methylcellulose. Based on symptoms and clinical signs of anaphylaxis following 2 separate cataract operations together with positive prick tests to HPMC, HPMC is the most plausible cause of the reactions. The patient has since had uneventful surgery for a detached retina avoiding HPMC. This case stresses the importance of considering all medication given to patients as possible causes of an anaphylactic reaction.

KW - Aged

KW - Anaphylaxis

KW - Cataract Extraction

KW - Drug Hypersensitivity

KW - Humans

KW - Male

KW - Methylcellulose

KW - Ophthalmic Solutions

KW - Recurrence

KW - Skin Tests

U2 - 10.1016/j.jcrs.2013.02.034

DO - 10.1016/j.jcrs.2013.02.034

M3 - Journal article

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JO - Journal of Cataract & Refractive Surgery

JF - Journal of Cataract & Refractive Surgery

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