Uncoupling of collagen II metabolism in newly diagnosed, untreated rheumatoid arthritis is linked to inflammation and antibodies against cyclic citrullinated peptides

Anne Friesgaard Christensen; Kim Hørslev-Petersen; Stephan Christgau; Hanne Merete Lindegaard; Tine Lottenburger; Kirsten Junker; Merete Lund Hetland; Kristian Stengaard-Pedersen; Søren Jacobsen; Torkell Ellingsen; Lis Smedegaard Andersen; Ib Hansen; Henrik Skjødt; Jens Kristian Pedersen; Ulrik Birk Lauridsen; Anders Jørgen Svendsen; Ulrik Tarp; Jan Pødenphanth; Niels H H Heegaard; Aage Vestergaard; Anne Grethe Jurik; Mikkel Østergaard; Peter Junker

doi:10.3899/jrheum.091265

Uncoupling of collagen II metabolism in newly diagnosed, untreated rheumatoid arthritis is linked to inflammation and antibodies against cyclic citrullinated peptides

Anne Friesgaard Christensen, Kim Hørslev-Petersen, Stephan Christgau, Hanne Merete Lindegaard, Tine Lottenburger, Kirsten Junker, Merete Lund Hetland, Kristian Stengaard-Pedersen, Søren Jacobsen, Torkell Ellingsen, Lis Smedegaard Andersen, Ib Hansen, Henrik Skjødt, Jens Kristian Pedersen, Ulrik Birk Lauridsen, Anders Jørgen Svendsen, Ulrik Tarp, Jan Pødenphanth, Niels H H Heegaard, Aage VestergaardAnne Grethe Jurik, Mikkel Østergaard, Peter Junker

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

14 Citationer (Scopus)

Abstract

Objective. To investigate the relationship between markers of collagen 11 synthesis and degradation with disease activity measures, autoantibodies, and radiographic outcomes in a 4-year protocol on patients with early rheumatoid arthritis (RA) who are naive to disease-modifying antirheumatic drugs. Methods. One hundred sixty patients with newly diagnosed, untreated RA entered the Cyclosporine, Methotrexate, Steroid in RA (CIMESTRA) trial. Disease activity and radiograph status were measured at baseline and 4 years. The N-terminal propeptide of collagen IIA (PIIANP) and the crosslinked C-telopeptide of collagen II (CTX-II) were quantified at baseline by ELISA. PIIANP was also assayed at 2 and 4 years. Anticyclic citrullinated peptide (anti-CCP) was recorded at baseline. An uncoupling index for cartilage collagen metabolism was calculated from PHANP and CTX-II measurements. Results. PIIANP was low at diagnosis and 4 years on (p

Originalsprog	Engelsk
Tidsskrift	Journal of Rheumatology
Vol/bind	37
Udgave nummer	6
Sider (fra-til)	1113-20
Antal sider	8
ISSN	0315-162X
DOI	https://doi.org/10.3899/jrheum.091265
Status	Udgivet - 2010

Adgang til dokumentet

10.3899/jrheum.091265

Citationsformater

Christensen, A. F., Hørslev-Petersen, K., Christgau, S., Lindegaard, H. M., Lottenburger, T., Junker, K., Hetland, M. L., Stengaard-Pedersen, K., Jacobsen, S., Ellingsen, T., Andersen, L. S., Hansen, I., Skjødt, H., Pedersen, J. K., Lauridsen, U. B., Svendsen, A. J., Tarp, U., Pødenphanth, J., Heegaard, N. H. H., ... Junker, P. (2010). Uncoupling of collagen II metabolism in newly diagnosed, untreated rheumatoid arthritis is linked to inflammation and antibodies against cyclic citrullinated peptides. Journal of Rheumatology, 37(6), 1113-20. https://doi.org/10.3899/jrheum.091265

Uncoupling of collagen II metabolism in newly diagnosed, untreated rheumatoid arthritis is linked to inflammation and antibodies against cyclic citrullinated peptides. / Christensen, Anne Friesgaard; Hørslev-Petersen, Kim; Christgau, Stephan et al.
I: Journal of Rheumatology, Bind 37, Nr. 6, 2010, s. 1113-20.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Christensen, AF, Hørslev-Petersen, K, Christgau, S, Lindegaard, HM, Lottenburger, T, Junker, K, Hetland, ML, Stengaard-Pedersen, K, Jacobsen, S, Ellingsen, T, Andersen, LS, Hansen, I, Skjødt, H, Pedersen, JK, Lauridsen, UB, Svendsen, AJ, Tarp, U, Pødenphanth, J, Heegaard, NHH, Vestergaard, A, Jurik, AG, Østergaard, M & Junker, P 2010, 'Uncoupling of collagen II metabolism in newly diagnosed, untreated rheumatoid arthritis is linked to inflammation and antibodies against cyclic citrullinated peptides', Journal of Rheumatology, bind 37, nr. 6, s. 1113-20. https://doi.org/10.3899/jrheum.091265

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title = "Uncoupling of collagen II metabolism in newly diagnosed, untreated rheumatoid arthritis is linked to inflammation and antibodies against cyclic citrullinated peptides",

abstract = "Objective. To investigate the relationship between markers of collagen 11 synthesis and degradation with disease activity measures, autoantibodies, and radiographic outcomes in a 4-year protocol on patients with early rheumatoid arthritis (RA) who are naive to disease-modifying antirheumatic drugs. Methods. One hundred sixty patients with newly diagnosed, untreated RA entered the Cyclosporine, Methotrexate, Steroid in RA (CIMESTRA) trial. Disease activity and radiograph status were measured at baseline and 4 years. The N-terminal propeptide of collagen IIA (PIIANP) and the crosslinked C-telopeptide of collagen II (CTX-II) were quantified at baseline by ELISA. PIIANP was also assayed at 2 and 4 years. Anticyclic citrullinated peptide (anti-CCP) was recorded at baseline. An uncoupling index for cartilage collagen metabolism was calculated from PHANP and CTX-II measurements. Results. PIIANP was low at diagnosis and 4 years on (p",

author = "Christensen, {Anne Friesgaard} and Kim H{\o}rslev-Petersen and Stephan Christgau and Lindegaard, {Hanne Merete} and Tine Lottenburger and Kirsten Junker and Hetland, {Merete Lund} and Kristian Stengaard-Pedersen and S{\o}ren Jacobsen and Torkell Ellingsen and Andersen, {Lis Smedegaard} and Ib Hansen and Henrik Skj{\o}dt and Pedersen, {Jens Kristian} and Lauridsen, {Ulrik Birk} and Svendsen, {Anders J{\o}rgen} and Ulrik Tarp and Jan P{\o}denphanth and Heegaard, {Niels H H} and Aage Vestergaard and Jurik, {Anne Grethe} and Mikkel {\O}stergaard and Peter Junker",

year = "2010",

doi = "10.3899/jrheum.091265",

language = "English",

volume = "37",

pages = "1113--20",

journal = "Journal of Rheumatology",

issn = "0315-162X",

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TY - JOUR

T1 - Uncoupling of collagen II metabolism in newly diagnosed, untreated rheumatoid arthritis is linked to inflammation and antibodies against cyclic citrullinated peptides

AU - Christensen, Anne Friesgaard

AU - Hørslev-Petersen, Kim

AU - Christgau, Stephan

AU - Lindegaard, Hanne Merete

AU - Lottenburger, Tine

AU - Junker, Kirsten

AU - Hetland, Merete Lund

AU - Stengaard-Pedersen, Kristian

AU - Jacobsen, Søren

AU - Ellingsen, Torkell

AU - Andersen, Lis Smedegaard

AU - Hansen, Ib

AU - Skjødt, Henrik

AU - Pedersen, Jens Kristian

AU - Lauridsen, Ulrik Birk

AU - Svendsen, Anders Jørgen

AU - Tarp, Ulrik

AU - Pødenphanth, Jan

AU - Heegaard, Niels H H

AU - Vestergaard, Aage

AU - Jurik, Anne Grethe

AU - Østergaard, Mikkel

AU - Junker, Peter

PY - 2010

Y1 - 2010

N2 - Objective. To investigate the relationship between markers of collagen 11 synthesis and degradation with disease activity measures, autoantibodies, and radiographic outcomes in a 4-year protocol on patients with early rheumatoid arthritis (RA) who are naive to disease-modifying antirheumatic drugs. Methods. One hundred sixty patients with newly diagnosed, untreated RA entered the Cyclosporine, Methotrexate, Steroid in RA (CIMESTRA) trial. Disease activity and radiograph status were measured at baseline and 4 years. The N-terminal propeptide of collagen IIA (PIIANP) and the crosslinked C-telopeptide of collagen II (CTX-II) were quantified at baseline by ELISA. PIIANP was also assayed at 2 and 4 years. Anticyclic citrullinated peptide (anti-CCP) was recorded at baseline. An uncoupling index for cartilage collagen metabolism was calculated from PHANP and CTX-II measurements. Results. PIIANP was low at diagnosis and 4 years on (p

AB - Objective. To investigate the relationship between markers of collagen 11 synthesis and degradation with disease activity measures, autoantibodies, and radiographic outcomes in a 4-year protocol on patients with early rheumatoid arthritis (RA) who are naive to disease-modifying antirheumatic drugs. Methods. One hundred sixty patients with newly diagnosed, untreated RA entered the Cyclosporine, Methotrexate, Steroid in RA (CIMESTRA) trial. Disease activity and radiograph status were measured at baseline and 4 years. The N-terminal propeptide of collagen IIA (PIIANP) and the crosslinked C-telopeptide of collagen II (CTX-II) were quantified at baseline by ELISA. PIIANP was also assayed at 2 and 4 years. Anticyclic citrullinated peptide (anti-CCP) was recorded at baseline. An uncoupling index for cartilage collagen metabolism was calculated from PHANP and CTX-II measurements. Results. PIIANP was low at diagnosis and 4 years on (p

U2 - 10.3899/jrheum.091265

DO - 10.3899/jrheum.091265

M3 - Journal article

SN - 0315-162X

VL - 37

SP - 1113

EP - 1120

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 6

ER -