Abstract
Recent studies of dynamic interactions between epigenetic modifications of a host organism and the composition or activity of its associated gut microbiota suggest an opportunity for the host to shape its microbiome through epigenetic alterations that lead to changes in gene expression and noncoding RNA activity. We use insights from microbiota-induced epigenetic changes to review the potential of the host to epigenetically regulate its gut microbiome, from which a bidirectional ‘epigenome–microbiome axis’ emerges. This axis embeds environmentally induced variation, which may influence the adaptive evolution of host–microbe interactions. We furthermore present our perspective on how the epigenome–microbiome axis can be understood and investigated within a holo-omic framework with potential applications in the applied health and food sciences.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Trends in Microbiology |
| Vol/bind | 32 |
| Udgave nummer | 12 |
| Sider (fra-til) | 1229-1240 |
| Antal sider | 12 |
| ISSN | 0966-842X |
| DOI | |
| Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:We thank Tom Gilbert, \u00D8ystein Lie and members of the Applied Hologenomics group at CEH for stimulating discussions on the topic. We thank Shankar Iyer and two anonymous reviewers for valuable comments on previous versions of the manuscript. This project was funded by The Danish National Research Foundation (CEH \u2013 DNRF143), a Carlsberg Foundation award to M.T.L. (CF21-0356) and the European Union's Horizon 2020 Action grant to M.T.L. (952914 'FindingPheno'). Figures were created with BioRender.com. The authors declare no competing interests.
Funding Information:
We thank Tom Gilbert, \u00D8ystein Lie and members of the Applied Hologenomics group at CEH for stimulating discussions on the topic. We thank Shankar Iyer and two anonymous reviewers for valuable comments on previous versions of the manuscript. This project was funded by The Danish National Research Foundation award ( CEH \u2013 DNRF143 ), a Carlsberg Foundation award to M.T.L. ( CF21-0356 ) and the European Union\u2019s Horizon 2020 Action grant to M.T.L. ( 952914 \u201CFindingPheno\u201D). Figures were created with BioRender.com .
Publisher Copyright:
© 2024 The Author(s)