Abstract
Extrachromosomal circular DNAs (eccDNAs) are a type of circular DNAs originating from but independent of chromosomal DNAs. Nowadays, with the rapid development of sequencing and bioinformatics, the accuracy of eccDNAs detection has significantly improved. This advancement has consequently enhanced the feasibility of exploring the biological characteristics and functions of eccDNAs. This review elucidates the potential mechanisms of eccDNA generation, the existing methods for their detection and analysis, and their basic features. Furthermore, it focuses on the biological functions of eccDNAs in regulating gene expression under both physiological and pathological conditions. Additionally, the review summarizes the clinical implications of eccDNAs in human cancers and health.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 276 |
| Tidsskrift | Molecular Cancer |
| Vol/bind | 23 |
| Udgave nummer | 1 |
| Antal sider | 30 |
| ISSN | 1476-4598 |
| DOI | |
| Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:The authors thank the OE Biotech CO. Ltd. (Shanghai, China) for supporting. The figures were created using Figdraw 2.0 on Home for Researchers.\u00A0We thank the investigators whose studies have not yet been cited.
Funding Information:
This work was funded by the grants from Clinical Research Fund of the Seventh Affiliated Hospital, Sun Yat-sen University (ZSQYLCKYJJ202317), Shenzhen Medical Research Special Fund Project of Shenzhen Medical Academy of Research and Translation (A2301001), Shenzhen Science and Technology Innovation Commission (JCYJ20220530145014033 and JCYJ20230807110401003), the Research Start-up Fund of the Seventh Affiliated Hospital, Sun Yat-sen University (592026), Guangdong Provincial Key Laboratory of Digestive Cancer Research (2021B1212040006), the Open Fund of Guangdong Provincial Key Laboratory of Digestive Cancer Research (GPKLDCR202206M), Fundamental Research Funds for the Central Universities, Sun Yat-sen University (2023KYPT02) and the Lateral Research Project of Sun Yat-sen University (ZSQY-XQ-2309\u20130884).
Publisher Copyright:
© The Author(s) 2024.