Updates from the Danish studies of neuroinflammation in psychiatry – Immune exposures from fetus life to disease onset including the influence of immunogenetics and anti-inflammatory treatments

In this session we will present new studies since the last meeting utilizing the nationwide Danish registers and biobanks, with longitudinal information on immune-related exposure and associations with mental disorders. 1. Parental infections during fetal life and risk of mental disorders in the child-presenter Cecilie Lydholm, Research-year student: Presentation of the largest study conducted so far of all treated parental infections during pregnancy and the subsequent risk of mental illness in the offspring, including comparison groups of parental infections outside of the pregnancy period. 2. Infections and the risk of mental disorder, including immune markers at disease onset and new meta-analysis of antiinflammatory treatment-presenter Ole Kohler-Forsberg, MD, PhD-student: Presentation of (1) nationwide study of all treated infections and the subsequent risk of mental disorders, (2) populationbased study of CRP and leucocyte levels in people with schizophrenia and affective disorders, together with associations with mortality, and (3) Updated meta-analysis of randomized studies with anti-inflammatory treatment and efficacy on depression and depressive symptoms. 3. CNS infections and the risk of mental disorders-presenter Emilie Marie Juelstorp Pedersen, Research-year student: Presentation of the largest study on CNS infections with specific types and the longitudinal risk of mental illness and the effect on school performance. 4. Systematic review and meta-analysis of all immune-related CSF studies-presenter Sonja Orlovska, MD, PhD-student: Presentation of the first systematic review and meta-analysis of all immune-related CSF studies conducted on individuals with psychosis and affective disorders. 5. Autoantibody test results and immunogenetics in relation to mental disorders-presenter Michael Eriksen Benros, Senior Researcher, MD, PhD: Presentation of (1) Nationwide autoantibody test results and longitudinal associations with mental illness. (2) Immunogenetic studies on the largest gene-environmental cohort (iPSYCH) with >80,000 tested, out of which 50,000 have mental disorders (Autism, ADHD, Schizophrenia, Bipolar and Affective disorders), where associations between mental illness and immune-related genes will be explored.