Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | International Journal of Cancer |
| Vol/bind | 126 |
| Udgave nummer | 2 |
| Sider (fra-til) | 405-415 |
| Antal sider | 11 |
| ISSN | 0020-7136 |
| DOI | |
| Status | Udgivet - 2010 |
Bibliografisk note
Keywords: Antibodies, Bacterial; Costa Rica; Fluorescent Antibody Technique; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Immunohistochemistry; Macrophages; Microscopy, Confocal; Neoplasm Invasiveness; Neutrophils; Norway; Prognosis; Receptors, Urokinase Plasminogen Activator; Stomach NeoplasmsAdgang til dokumentet
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Urokinase plasminogen activator receptor is expressed in invasive cells in gastric carcinomas from high- and low-risk countries. / Alpizar Alpizar, Warner Enrique; Nielsen, Boye Schnack; Sierra, Rafaela; Illemann, Martin; Ramírez, Jose A.; Arias, Adriana; Durán, Sundry; Skarstein, Arne; Ovrebo, Kjell; Lund, Leif R.; Laerum, Ole D.
I: International Journal of Cancer, Bind 126, Nr. 2, 2010, s. 405-415.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Urokinase plasminogen activator receptor is expressed in invasive cells in gastric carcinomas from high- and low-risk countries
AU - Alpizar Alpizar, Warner Enrique
AU - Nielsen, Boye Schnack
AU - Sierra, Rafaela
AU - Illemann, Martin
AU - Ramírez, Jose A.
AU - Arias, Adriana
AU - Durán, Sundry
AU - Skarstein, Arne
AU - Ovrebo, Kjell
AU - Lund, Leif R.
AU - Laerum, Ole D
N1 - Keywords: Antibodies, Bacterial; Costa Rica; Fluorescent Antibody Technique; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Immunohistochemistry; Macrophages; Microscopy, Confocal; Neoplasm Invasiveness; Neutrophils; Norway; Prognosis; Receptors, Urokinase Plasminogen Activator; Stomach Neoplasms
PY - 2010
Y1 - 2010
N2 - Gastric cancer is the second cancer causing death worldwide. Both incidence and mortality rates vary according to geographical regions. The receptor for urokinase plasminogen activator (uPAR) is involved in extracellular matrix degradation by mediating cell surface associated plasminogen activation, and its presence on gastric cancer cells is linked to micro-metastasis and poor prognosis. Immunohistochemical analyses of a set of 44 gastric cancer lesions from Costa Rica showed expression of uPAR in cancer cells in both intestinal subtype (14 of 27) and diffuse subtype (10 of 17). We compared the expression pattern of uPAR in gastric cancers from a high-risk country (Costa Rica) with a low-risk country (Norway). We found uPAR on gastric cancer cells in 24 of 44 cases (54%) from Costa Rica and in 13 of 23 cases (56%) from Norway. uPAR was seen in macrophages and neutrophils in all cases. We also examined the nonneoplastic mucosa and found that uPAR was more frequently seen in epithelial cells located at the luminal edge of the crypts in cases with Helicobacter pylori infection than in similar epithelial cells in noninfected mucosa (p = 0.033; chi(2) = 4.54). In conclusion, the expression of uPAR in cancer cells in more than half of the gastric cancer cases suggests that their uPAR-positivity do not contribute to explain the different mortality rates between the 2 countries, however, the actual prevalence of uPAR-positive cancer cells in the gastric cancers may still provide prognostic information.
AB - Gastric cancer is the second cancer causing death worldwide. Both incidence and mortality rates vary according to geographical regions. The receptor for urokinase plasminogen activator (uPAR) is involved in extracellular matrix degradation by mediating cell surface associated plasminogen activation, and its presence on gastric cancer cells is linked to micro-metastasis and poor prognosis. Immunohistochemical analyses of a set of 44 gastric cancer lesions from Costa Rica showed expression of uPAR in cancer cells in both intestinal subtype (14 of 27) and diffuse subtype (10 of 17). We compared the expression pattern of uPAR in gastric cancers from a high-risk country (Costa Rica) with a low-risk country (Norway). We found uPAR on gastric cancer cells in 24 of 44 cases (54%) from Costa Rica and in 13 of 23 cases (56%) from Norway. uPAR was seen in macrophages and neutrophils in all cases. We also examined the nonneoplastic mucosa and found that uPAR was more frequently seen in epithelial cells located at the luminal edge of the crypts in cases with Helicobacter pylori infection than in similar epithelial cells in noninfected mucosa (p = 0.033; chi(2) = 4.54). In conclusion, the expression of uPAR in cancer cells in more than half of the gastric cancer cases suggests that their uPAR-positivity do not contribute to explain the different mortality rates between the 2 countries, however, the actual prevalence of uPAR-positive cancer cells in the gastric cancers may still provide prognostic information.
U2 - 10.1002/ijc.24755
DO - 10.1002/ijc.24755
M3 - Journal article
C2 - 19609941
VL - 126
SP - 405
EP - 415
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 2
ER -