Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort

Stine Gry Kristensen; Yu Wakimoto; Lotte Berdiin Colmorn; Margit Dueholm; Susanne Elisabeth Pors; Kirsten Tryde Macklon; Linn Salto Mamsen; Dmitry Nikiforov; Jesús Cadenas; Vinnie Hornshøj Greve; Anne-Mette Bay Bjørn; Mikkel Rosendahl; Anette Tønnes Pedersen; Anders Nyboe Andersen; Jens Fedder; Erik Ernst; Claus Yding Andersen

doi:10.1016/j.fertnstert.2021.05.096

Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort

Stine Gry Kristensen, Yu Wakimoto, Lotte Berdiin Colmorn, Margit Dueholm, Susanne Elisabeth Pors, Kirsten Tryde Macklon, Linn Salto Mamsen, Dmitry Nikiforov, Jesús Cadenas, Vinnie Hornshøj Greve, Anne-Mette Bay Bjørn, Mikkel Rosendahl, Anette Tønnes Pedersen, Anders Nyboe Andersen, Jens Fedder, Erik Ernst, Claus Yding Andersen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

25 Citationer (Scopus)

16 Downloads (Pure)

Abstract

OBJECTIVE: To evaluate the use of cryopreserved ovarian tissue in the Danish fertility preservation cohort.

DESIGN: Retrospective cohort study.

SETTING: University hospitals and fertility clinics.

PATIENT(S): Ovarian tissue cryopreservation (OTC) was performed for 1,186 Danish girls and women from 1999-2020, of whom 117 subsequently underwent ovarian tissue transplantation (OTT). Subgroup 1 included 759 patients with a follow-up period of >5 years. Out of these, OTT rates were further analyzed for those patients who were alive and aged >24 years in July 2020 (subgroup 2; n = 554).

INTERVENTION(S): OTC and OTT.

MAIN OUTCOME MEASURE(S): OTT, death, donation of tissue.

RESULT(S): In subgroup 1, 14% of the patients had undergone OTT, 18% had died, 9% had donated their tissue for research, and 59% still had their tissue stored. In subgroup 2, 19% had undergone OTT and for most diagnoses the OTT rates ranged from 15% to 22% with benign hematologic diseases having the highest OTT rate (35%). On the basis of the entire cohort, stratified age analysis indicated that women aged ≥30 years at OTC were more likely to return for OTT than women aged 18-29 years at OTC; mean storage times were 3.7 and 3.6 years, respectively. Only 4% of the girls aged <18 years at OTC had undergone OTT.

CONCLUSION(S): The OTT rates depended on the diagnosis, age at OTC, and follow-up time. Specific criteria are needed for reporting and comparing OTT rates. Six out of 10 patients still had their cryopreserved tissue stored and longer follow-up is needed, especially for younger girls.

Originalsprog	Engelsk
Tidsskrift	Fertility and Sterility
Vol/bind	116
Udgave nummer	4
Sider (fra-til)	1098-1106
Antal sider	9
ISSN	0015-0282
DOI	https://doi.org/10.1016/j.fertnstert.2021.05.096
Status	Udgivet - 2021

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10.1016/j.fertnstert.2021.05.096Licens: CC BY

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Citationsformater

Kristensen, S. G., Wakimoto, Y., Colmorn, L. B., Dueholm, M., Pors, S. E., Macklon, K. T., Mamsen, L. S., Nikiforov, D., Cadenas, J., Greve, V. H., Bay Bjørn, A-M., Rosendahl, M., Pedersen, A. T., Nyboe Andersen, A., Fedder, J., Ernst, E., & Andersen, C. Y. (2021). Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort. Fertility and Sterility, 116(4), 1098-1106. https://doi.org/10.1016/j.fertnstert.2021.05.096

Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort. / Kristensen, Stine Gry; Wakimoto, Yu; Colmorn, Lotte Berdiin; Dueholm, Margit; Pors, Susanne Elisabeth; Macklon, Kirsten Tryde; Mamsen, Linn Salto; Nikiforov, Dmitry; Cadenas, Jesús; Greve, Vinnie Hornshøj; Bay Bjørn, Anne-Mette; Rosendahl, Mikkel; Pedersen, Anette Tønnes; Nyboe Andersen, Anders; Fedder, Jens; Ernst, Erik; Andersen, Claus Yding.

I: Fertility and Sterility, Bind 116, Nr. 4, 2021, s. 1098-1106.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Kristensen, SG, Wakimoto, Y, Colmorn, LB, Dueholm, M, Pors, SE, Macklon, KT, Mamsen, LS, Nikiforov, D, Cadenas, J, Greve, VH, Bay Bjørn, A-M, Rosendahl, M, Pedersen, AT, Nyboe Andersen, A, Fedder, J, Ernst, E & Andersen, CY 2021, 'Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort', Fertility and Sterility, bind 116, nr. 4, s. 1098-1106. https://doi.org/10.1016/j.fertnstert.2021.05.096

Kristensen, Stine Gry ; Wakimoto, Yu ; Colmorn, Lotte Berdiin ; Dueholm, Margit ; Pors, Susanne Elisabeth ; Macklon, Kirsten Tryde ; Mamsen, Linn Salto ; Nikiforov, Dmitry ; Cadenas, Jesús ; Greve, Vinnie Hornshøj ; Bay Bjørn, Anne-Mette ; Rosendahl, Mikkel ; Pedersen, Anette Tønnes ; Nyboe Andersen, Anders ; Fedder, Jens ; Ernst, Erik ; Andersen, Claus Yding. / Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort. I: Fertility and Sterility. 2021 ; Bind 116, Nr. 4. s. 1098-1106.

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title = "Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort",

abstract = "OBJECTIVE: To evaluate the use of cryopreserved ovarian tissue in the Danish fertility preservation cohort.DESIGN: Retrospective cohort study.SETTING: University hospitals and fertility clinics.PATIENT(S): Ovarian tissue cryopreservation (OTC) was performed for 1,186 Danish girls and women from 1999-2020, of whom 117 subsequently underwent ovarian tissue transplantation (OTT). Subgroup 1 included 759 patients with a follow-up period of >5 years. Out of these, OTT rates were further analyzed for those patients who were alive and aged >24 years in July 2020 (subgroup 2; n = 554).INTERVENTION(S): OTC and OTT.MAIN OUTCOME MEASURE(S): OTT, death, donation of tissue.RESULT(S): In subgroup 1, 14% of the patients had undergone OTT, 18% had died, 9% had donated their tissue for research, and 59% still had their tissue stored. In subgroup 2, 19% had undergone OTT and for most diagnoses the OTT rates ranged from 15% to 22% with benign hematologic diseases having the highest OTT rate (35%). On the basis of the entire cohort, stratified age analysis indicated that women aged ≥30 years at OTC were more likely to return for OTT than women aged 18-29 years at OTC; mean storage times were 3.7 and 3.6 years, respectively. Only 4% of the girls aged <18 years at OTC had undergone OTT.CONCLUSION(S): The OTT rates depended on the diagnosis, age at OTC, and follow-up time. Specific criteria are needed for reporting and comparing OTT rates. Six out of 10 patients still had their cryopreserved tissue stored and longer follow-up is needed, especially for younger girls.",

keywords = "Adolescent, Adult, Cryopreservation/trends, Denmark, Female, Fertility, Fertility Preservation, Humans, Infertility, Female/diagnosis, Organ Transplantation/trends, Ovary/transplantation, Pregnancy, Primary Ovarian Insufficiency/etiology, Retrospective Studies, Risk Factors, Time Factors, Young Adult",

author = "Kristensen, {Stine Gry} and Yu Wakimoto and Colmorn, {Lotte Berdiin} and Margit Dueholm and Pors, {Susanne Elisabeth} and Macklon, {Kirsten Tryde} and Mamsen, {Linn Salto} and Dmitry Nikiforov and Jes{\'u}s Cadenas and Greve, {Vinnie Hornsh{\o}j} and {Bay Bj{\o}rn}, Anne-Mette and Mikkel Rosendahl and Pedersen, {Anette T{\o}nnes} and {Nyboe Andersen}, Anders and Jens Fedder and Erik Ernst and Andersen, {Claus Yding}",

year = "2021",

doi = "10.1016/j.fertnstert.2021.05.096",

language = "English",

volume = "116",

pages = "1098--1106",

journal = "Sexuality, Reproduction and Menopause",

issn = "1546-2501",

publisher = "Elsevier",

number = "4",

}

TY - JOUR

T1 - Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort

AU - Kristensen, Stine Gry

AU - Wakimoto, Yu

AU - Colmorn, Lotte Berdiin

AU - Dueholm, Margit

AU - Pors, Susanne Elisabeth

AU - Macklon, Kirsten Tryde

AU - Mamsen, Linn Salto

AU - Nikiforov, Dmitry

AU - Cadenas, Jesús

AU - Greve, Vinnie Hornshøj

AU - Bay Bjørn, Anne-Mette

AU - Rosendahl, Mikkel

AU - Pedersen, Anette Tønnes

AU - Nyboe Andersen, Anders

AU - Fedder, Jens

AU - Ernst, Erik

AU - Andersen, Claus Yding

PY - 2021

Y1 - 2021

N2 - OBJECTIVE: To evaluate the use of cryopreserved ovarian tissue in the Danish fertility preservation cohort.DESIGN: Retrospective cohort study.SETTING: University hospitals and fertility clinics.PATIENT(S): Ovarian tissue cryopreservation (OTC) was performed for 1,186 Danish girls and women from 1999-2020, of whom 117 subsequently underwent ovarian tissue transplantation (OTT). Subgroup 1 included 759 patients with a follow-up period of >5 years. Out of these, OTT rates were further analyzed for those patients who were alive and aged >24 years in July 2020 (subgroup 2; n = 554).INTERVENTION(S): OTC and OTT.MAIN OUTCOME MEASURE(S): OTT, death, donation of tissue.RESULT(S): In subgroup 1, 14% of the patients had undergone OTT, 18% had died, 9% had donated their tissue for research, and 59% still had their tissue stored. In subgroup 2, 19% had undergone OTT and for most diagnoses the OTT rates ranged from 15% to 22% with benign hematologic diseases having the highest OTT rate (35%). On the basis of the entire cohort, stratified age analysis indicated that women aged ≥30 years at OTC were more likely to return for OTT than women aged 18-29 years at OTC; mean storage times were 3.7 and 3.6 years, respectively. Only 4% of the girls aged <18 years at OTC had undergone OTT.CONCLUSION(S): The OTT rates depended on the diagnosis, age at OTC, and follow-up time. Specific criteria are needed for reporting and comparing OTT rates. Six out of 10 patients still had their cryopreserved tissue stored and longer follow-up is needed, especially for younger girls.

AB - OBJECTIVE: To evaluate the use of cryopreserved ovarian tissue in the Danish fertility preservation cohort.DESIGN: Retrospective cohort study.SETTING: University hospitals and fertility clinics.PATIENT(S): Ovarian tissue cryopreservation (OTC) was performed for 1,186 Danish girls and women from 1999-2020, of whom 117 subsequently underwent ovarian tissue transplantation (OTT). Subgroup 1 included 759 patients with a follow-up period of >5 years. Out of these, OTT rates were further analyzed for those patients who were alive and aged >24 years in July 2020 (subgroup 2; n = 554).INTERVENTION(S): OTC and OTT.MAIN OUTCOME MEASURE(S): OTT, death, donation of tissue.RESULT(S): In subgroup 1, 14% of the patients had undergone OTT, 18% had died, 9% had donated their tissue for research, and 59% still had their tissue stored. In subgroup 2, 19% had undergone OTT and for most diagnoses the OTT rates ranged from 15% to 22% with benign hematologic diseases having the highest OTT rate (35%). On the basis of the entire cohort, stratified age analysis indicated that women aged ≥30 years at OTC were more likely to return for OTT than women aged 18-29 years at OTC; mean storage times were 3.7 and 3.6 years, respectively. Only 4% of the girls aged <18 years at OTC had undergone OTT.CONCLUSION(S): The OTT rates depended on the diagnosis, age at OTC, and follow-up time. Specific criteria are needed for reporting and comparing OTT rates. Six out of 10 patients still had their cryopreserved tissue stored and longer follow-up is needed, especially for younger girls.

KW - Adolescent

KW - Adult

KW - Cryopreservation/trends

KW - Denmark

KW - Female

KW - Fertility

KW - Fertility Preservation

KW - Humans

KW - Infertility, Female/diagnosis

KW - Organ Transplantation/trends

KW - Ovary/transplantation

KW - Pregnancy

KW - Primary Ovarian Insufficiency/etiology

KW - Retrospective Studies

KW - Risk Factors

KW - Time Factors

KW - Young Adult

U2 - 10.1016/j.fertnstert.2021.05.096

DO - 10.1016/j.fertnstert.2021.05.096

M3 - Journal article

C2 - 34130800

VL - 116

SP - 1098

EP - 1106

JO - Sexuality, Reproduction and Menopause

JF - Sexuality, Reproduction and Menopause

SN - 1546-2501

IS - 4

ER -