Validation of a register-based algorithm for recurrence in rectal cancer

Emilie Palmgren Colov; Tina Fransgaard; Mads Klein; Ismail Gögenur

Validation of a register-based algorithm for recurrence in rectal cancer

Emilie Palmgren Colov, Tina Fransgaard, Mads Klein, Ismail Gögenur

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

INTRODUCTION: Colorectal cancer is the third most common type of cancer worldwide. Recurrence is an important end-point in colorectal cancer research. This study aimed to validate a previously developed algorithm to determine recurrence after surgery for rectal cancer.

METHODS: Information about a cohort of 500 patients with rectal cancer was retrieved from the Danish Civil Registration System, the Danish National Patient Register and the Danish National Pathology Register. Patients with an ICD-10 code for metastatic disease, chemotherapy or SNOMED code suggesting metastasis were identified as having recurrence. In a previous study, medical records of the same cohort had been reviewed to identify recurrence. Recurrence identified by the algorithm was compared with the previously retrieved information from the medical records using Kappa statistics. The sensitivity and specificity of the algorithm were determined.

RESULTS: Of the 500 patients, 393 were included in the validation analysis. Kappa statistics showed good concordance with a Kappa value (95% confidence interval) of 0.80 (0.72-0.88). The sensitivity and specificity of the algorithm were 88% (77-95%) and 96% (93-98%), respectively.

CONCLUSIONS: The study showed good concordance between the algorithm and medical record information. The algorithm makes it possible to perform large register-based studies of recurrence and disease-free survival in colorectal cancer patients without the need for evaluation of medical records.

FUNDING: none.

TRIAL REGISTRATION: not relevant.

Originalsprog	Engelsk
Artikelnummer	A5507
Tidsskrift	Danish Medical Journal
Vol/bind	65
Udgave nummer	10
Antal sider	4
ISSN	1603-9629
Status	Udgivet - 2018

Bibliografisk note

Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Validation of a register-based algorithm for recurrence in rectal cancerForlagets udgivne version, 82,2 KBLicens: Ikke-specificeret

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Citationsformater

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title = "Validation of a register-based algorithm for recurrence in rectal cancer",

abstract = "INTRODUCTION: Colorectal cancer is the third most common type of cancer worldwide. Recurrence is an important end-point in colorectal cancer research. This study aimed to validate a previously developed algorithm to determine recurrence after surgery for rectal cancer.METHODS: Information about a cohort of 500 patients with rectal cancer was retrieved from the Danish Civil Registration System, the Danish National Patient Register and the Danish National Pathology Register. Patients with an ICD-10 code for metastatic disease, chemotherapy or SNOMED code suggesting metastasis were identified as having recurrence. In a previous study, medical records of the same cohort had been reviewed to identify recurrence. Recurrence identified by the algorithm was compared with the previously retrieved information from the medical records using Kappa statistics. The sensitivity and specificity of the algorithm were determined.RESULTS: Of the 500 patients, 393 were included in the validation analysis. Kappa statistics showed good concordance with a Kappa value (95% confidence interval) of 0.80 (0.72-0.88). The sensitivity and specificity of the algorithm were 88% (77-95%) and 96% (93-98%), respectively.CONCLUSIONS: The study showed good concordance between the algorithm and medical record information. The algorithm makes it possible to perform large register-based studies of recurrence and disease-free survival in colorectal cancer patients without the need for evaluation of medical records.FUNDING: none.TRIAL REGISTRATION: not relevant.",

keywords = "Algorithms, Cohort Studies, Colorectal Neoplasms/epidemiology, Denmark/epidemiology, Humans, Incidence, Neoplasm Recurrence, Local/epidemiology, Registries, Sensitivity and Specificity",

author = "Colov, {Emilie Palmgren} and Tina Fransgaard and Mads Klein and Ismail G{\"o}genur",

note = "Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.",

year = "2018",

language = "English",

volume = "65",

journal = "Danish Medical Journal",

issn = "1603-9629",

publisher = "Almindelige Danske Laegeforening",

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TY - JOUR

T1 - Validation of a register-based algorithm for recurrence in rectal cancer

AU - Colov, Emilie Palmgren

AU - Fransgaard, Tina

AU - Klein, Mads

AU - Gögenur, Ismail

N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

PY - 2018

Y1 - 2018

N2 - INTRODUCTION: Colorectal cancer is the third most common type of cancer worldwide. Recurrence is an important end-point in colorectal cancer research. This study aimed to validate a previously developed algorithm to determine recurrence after surgery for rectal cancer.METHODS: Information about a cohort of 500 patients with rectal cancer was retrieved from the Danish Civil Registration System, the Danish National Patient Register and the Danish National Pathology Register. Patients with an ICD-10 code for metastatic disease, chemotherapy or SNOMED code suggesting metastasis were identified as having recurrence. In a previous study, medical records of the same cohort had been reviewed to identify recurrence. Recurrence identified by the algorithm was compared with the previously retrieved information from the medical records using Kappa statistics. The sensitivity and specificity of the algorithm were determined.RESULTS: Of the 500 patients, 393 were included in the validation analysis. Kappa statistics showed good concordance with a Kappa value (95% confidence interval) of 0.80 (0.72-0.88). The sensitivity and specificity of the algorithm were 88% (77-95%) and 96% (93-98%), respectively.CONCLUSIONS: The study showed good concordance between the algorithm and medical record information. The algorithm makes it possible to perform large register-based studies of recurrence and disease-free survival in colorectal cancer patients without the need for evaluation of medical records.FUNDING: none.TRIAL REGISTRATION: not relevant.

AB - INTRODUCTION: Colorectal cancer is the third most common type of cancer worldwide. Recurrence is an important end-point in colorectal cancer research. This study aimed to validate a previously developed algorithm to determine recurrence after surgery for rectal cancer.METHODS: Information about a cohort of 500 patients with rectal cancer was retrieved from the Danish Civil Registration System, the Danish National Patient Register and the Danish National Pathology Register. Patients with an ICD-10 code for metastatic disease, chemotherapy or SNOMED code suggesting metastasis were identified as having recurrence. In a previous study, medical records of the same cohort had been reviewed to identify recurrence. Recurrence identified by the algorithm was compared with the previously retrieved information from the medical records using Kappa statistics. The sensitivity and specificity of the algorithm were determined.RESULTS: Of the 500 patients, 393 were included in the validation analysis. Kappa statistics showed good concordance with a Kappa value (95% confidence interval) of 0.80 (0.72-0.88). The sensitivity and specificity of the algorithm were 88% (77-95%) and 96% (93-98%), respectively.CONCLUSIONS: The study showed good concordance between the algorithm and medical record information. The algorithm makes it possible to perform large register-based studies of recurrence and disease-free survival in colorectal cancer patients without the need for evaluation of medical records.FUNDING: none.TRIAL REGISTRATION: not relevant.

KW - Algorithms

KW - Cohort Studies

KW - Colorectal Neoplasms/epidemiology

KW - Denmark/epidemiology

KW - Humans

KW - Incidence

KW - Neoplasm Recurrence, Local/epidemiology

KW - Registries

KW - Sensitivity and Specificity

M3 - Journal article

C2 - 30269749

SN - 1603-9629

VL - 65

JO - Danish Medical Journal

JF - Danish Medical Journal

IS - 10

M1 - A5507

ER -