Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients

Gitte Kronborg; Nina Weis; Hans O Madsen; Svend S Pedersen; Christian Wejse; Henrik Nielsen; Peter Skinhøj; Peter Garred; Nina Weis

doi:10.1086/340216

Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients

Gitte Kronborg, Nina Weis, Hans O Madsen, Svend S Pedersen, Christian Wejse, Henrik Nielsen, Peter Skinhøj, Peter Garred, Nina Weis

Institut for Klinisk Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

103 Citationer (Scopus)

Abstract

Udgivelsesdato: 2002-May-15

Originalsprog	Engelsk
Tidsskrift	Journal of Infectious Diseases
Vol/bind	185
Udgave nummer	10
Sider (fra-til)	1517-20
Antal sider	3
ISSN	0022-1899
DOI	https://doi.org/10.1086/340216 https://doi.org/10.1086/340216
Status	Udgivet - 2002

Adgang til dokumentet

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11992290&itool=iconabstr&query_hl=13&itool=pubmed_docsum

Citationsformater

Kronborg, G., Weis, N., Madsen, H. O., Pedersen, S. S., Wejse, C., Nielsen, H., Skinhøj, P., Garred, P., & Weis, N. (2002). Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients. Journal of Infectious Diseases, 185(10), 1517-20. https://doi.org/10.1086/340216, https://doi.org/10.1086/340216

Kronborg, G, Weis, N, Madsen, HO, Pedersen, SS, Wejse, C, Nielsen, H, Skinhøj, P, Garred, P & Weis, N 2002, 'Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients', Journal of Infectious Diseases, bind 185, nr. 10, s. 1517-20. https://doi.org/10.1086/340216, https://doi.org/10.1086/340216

@article{834e4bc0bc604e75a4695946d6f9b948,

title = "Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients",

abstract = "Invasive pneumococcal disease is a serious infection that primarily affects very young children and elderly or immunocompromised individuals but also affects previously healthy people. Variant mannose-binding lectin (MBL) alleles are associated with recurrent infections and may be a risk factor for pneumococcal infections. To assess the influence of MBL genotypes on the course and outcome of invasive pneumococcal disease, clinical data for 141 adult patients were collected prospectively and their genotypes were determined. All patients included had positive blood cultures for Streptococcus pneumoniae. The distribution of variant MBL alleles related to low MBL serum concentrations was similar among the patients and healthy individuals, and MBL genotype was not associated with infection outcome. Thus, in a random adult population with invasive pneumococcal infection, MBL does not seem to play a role in the pathophysiology, in contrast to earlier observations in patients with other concomitant immune abnormalities.",

author = "Gitte Kronborg and Nina Weis and Madsen, {Hans O} and Pedersen, {Svend S} and Christian Wejse and Henrik Nielsen and Peter Skinh{\o}j and Peter Garred and Nina Weis",

year = "2002",

doi = "10.1086/340216",

language = "English",

volume = "185",

pages = "1517--20",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

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TY - JOUR

T1 - Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients

AU - Kronborg, Gitte

AU - Weis, Nina

AU - Madsen, Hans O

AU - Pedersen, Svend S

AU - Wejse, Christian

AU - Nielsen, Henrik

AU - Skinhøj, Peter

AU - Garred, Peter

AU - Weis, Nina

PY - 2002

Y1 - 2002

N2 - Invasive pneumococcal disease is a serious infection that primarily affects very young children and elderly or immunocompromised individuals but also affects previously healthy people. Variant mannose-binding lectin (MBL) alleles are associated with recurrent infections and may be a risk factor for pneumococcal infections. To assess the influence of MBL genotypes on the course and outcome of invasive pneumococcal disease, clinical data for 141 adult patients were collected prospectively and their genotypes were determined. All patients included had positive blood cultures for Streptococcus pneumoniae. The distribution of variant MBL alleles related to low MBL serum concentrations was similar among the patients and healthy individuals, and MBL genotype was not associated with infection outcome. Thus, in a random adult population with invasive pneumococcal infection, MBL does not seem to play a role in the pathophysiology, in contrast to earlier observations in patients with other concomitant immune abnormalities.

AB - Invasive pneumococcal disease is a serious infection that primarily affects very young children and elderly or immunocompromised individuals but also affects previously healthy people. Variant mannose-binding lectin (MBL) alleles are associated with recurrent infections and may be a risk factor for pneumococcal infections. To assess the influence of MBL genotypes on the course and outcome of invasive pneumococcal disease, clinical data for 141 adult patients were collected prospectively and their genotypes were determined. All patients included had positive blood cultures for Streptococcus pneumoniae. The distribution of variant MBL alleles related to low MBL serum concentrations was similar among the patients and healthy individuals, and MBL genotype was not associated with infection outcome. Thus, in a random adult population with invasive pneumococcal infection, MBL does not seem to play a role in the pathophysiology, in contrast to earlier observations in patients with other concomitant immune abnormalities.

U2 - 10.1086/340216

DO - 10.1086/340216

M3 - Journal article

C2 - 11992290

SN - 0022-1899

VL - 185

SP - 1517

EP - 1520

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 10

ER -