Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Lancet |
| Vol/bind | 363 |
| Udgave nummer | 9405 |
| Sider (fra-til) | 283-9 |
| Antal sider | 6 |
| ISSN | 0140-6736 |
| DOI | |
| Status | Udgivet - 2004 |
Bibliografisk note
Keywords: Animals; Antibodies, Protozoan; Antigens, Protozoan; Antigens, Surface; Cell Adhesion; Chondroitin Sulfates; Erythrocytes; Female; Flow Cytometry; Humans; Immunity, Natural; Immunoglobulin G; Infant, Low Birth Weight; Infant, Newborn; Malaria Vaccines; Malaria, Falciparum; Placenta Diseases; Plasmodium falciparum; Pregnancy; Pregnancy Complications, ParasiticAdgang til dokumentet
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Variant surface antigen-specific IgG and protection against clinical consequences of pregnancy-associated Plasmodium falciparum malaria. / Staalsoe, Trine; Shulman, Caroline E; Bulmer, Judith N; Kawuondo, Ken; Marsh, Kevin; Hviid, Lars.
I: Lancet, Bind 363, Nr. 9405, 2004, s. 283-9.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Variant surface antigen-specific IgG and protection against clinical consequences of pregnancy-associated Plasmodium falciparum malaria
AU - Staalsoe, Trine
AU - Shulman, Caroline E
AU - Bulmer, Judith N
AU - Kawuondo, Ken
AU - Marsh, Kevin
AU - Hviid, Lars
N1 - Keywords: Animals; Antibodies, Protozoan; Antigens, Protozoan; Antigens, Surface; Cell Adhesion; Chondroitin Sulfates; Erythrocytes; Female; Flow Cytometry; Humans; Immunity, Natural; Immunoglobulin G; Infant, Low Birth Weight; Infant, Newborn; Malaria Vaccines; Malaria, Falciparum; Placenta Diseases; Plasmodium falciparum; Pregnancy; Pregnancy Complications, Parasitic
PY - 2004
Y1 - 2004
N2 - BACKGROUND: Pregnancy-associated malaria caused by Plasmodium falciparum adherence to chondroitin sulfate A in the placental intervillous space is a major cause of low birthweight and maternal anaemia in areas of endemic P falciparum transmission. Adhesion-blocking antibodies that specifically recognise parasite-encoded variant surface antigens (VSA) are associated with resistance to pregnancy-associated malaria. We looked for a possible relation between VSA-specific antibody concentrations, placental infection, and protection from low birthweight and maternal anaemia. METHODS: We used flow cytometry to measure VSA-specific IgG concentrations in plasma samples taken during child birth from 477 Kenyan women selected from a cohort of 910 women on the basis of HIV-1 status, gravidity, and placental histology. We measured VSA expressed by one placental P falciparum isolate and two isolates selected or not selected for chondroitin sulfate A adhesiveness in-vitro. FINDINGS: Concentrations of plasma IgG specific for VSA, expressed by chondroitin sulfate A-adhering parasites (VSA in pregnancy-associated malaria or vsa-pam), increased with gravidity and were associated with placental histological findings. Women with chronic pregnancy-associated malaria and low or absent VSA-PAM-specific IgG had lower haemoglobin values (reduced by 17 g/L; 95% CI 8.1-25.2) and delivered smaller babies (birthweight reduced by 0.26 kg; 0.10-0.55) than did corresponding women with high VSA-PAM-specific IgG. No such relation was shown for concentrations of IgG with specificity for non-pregnancy-associated malaria VSA. INTERPRETATION: VSA-PAM-specific IgG protects against low birthweight and maternal anaemia. Our data indicate an important mechanism of clinical protection against malaria and raise hope for the clinical effectiveness of a potential VSA-based vaccine against pregnancy-associated malaria.
AB - BACKGROUND: Pregnancy-associated malaria caused by Plasmodium falciparum adherence to chondroitin sulfate A in the placental intervillous space is a major cause of low birthweight and maternal anaemia in areas of endemic P falciparum transmission. Adhesion-blocking antibodies that specifically recognise parasite-encoded variant surface antigens (VSA) are associated with resistance to pregnancy-associated malaria. We looked for a possible relation between VSA-specific antibody concentrations, placental infection, and protection from low birthweight and maternal anaemia. METHODS: We used flow cytometry to measure VSA-specific IgG concentrations in plasma samples taken during child birth from 477 Kenyan women selected from a cohort of 910 women on the basis of HIV-1 status, gravidity, and placental histology. We measured VSA expressed by one placental P falciparum isolate and two isolates selected or not selected for chondroitin sulfate A adhesiveness in-vitro. FINDINGS: Concentrations of plasma IgG specific for VSA, expressed by chondroitin sulfate A-adhering parasites (VSA in pregnancy-associated malaria or vsa-pam), increased with gravidity and were associated with placental histological findings. Women with chronic pregnancy-associated malaria and low or absent VSA-PAM-specific IgG had lower haemoglobin values (reduced by 17 g/L; 95% CI 8.1-25.2) and delivered smaller babies (birthweight reduced by 0.26 kg; 0.10-0.55) than did corresponding women with high VSA-PAM-specific IgG. No such relation was shown for concentrations of IgG with specificity for non-pregnancy-associated malaria VSA. INTERPRETATION: VSA-PAM-specific IgG protects against low birthweight and maternal anaemia. Our data indicate an important mechanism of clinical protection against malaria and raise hope for the clinical effectiveness of a potential VSA-based vaccine against pregnancy-associated malaria.
U2 - 10.1016/S0140-6736(03)15386-X
DO - 10.1016/S0140-6736(03)15386-X
M3 - Journal article
C2 - 14751701
VL - 363
SP - 283
EP - 289
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 9405
ER -