TY - JOUR
T1 - Variant surface antigens, virulence genes and the pathogenesis of malaria
AU - Deitsch, Kirk W
AU - Hviid, Lars
N1 - Keywords: Animals; Antigens, Protozoan; Antigens, Surface; Gene Expression Regulation; Humans; Malaria, Falciparum; Plasmodium falciparum; Protozoan Proteins; Telomere; Virulence
PY - 2004
Y1 - 2004
N2 - The first Molecular Approaches to Malaria meeting was held 2-5 February 2000 in Lorne, Australia. Following the meeting, Brian Cooke, Mats Wahlgren and Ross Coppel predicted that research into the molecular details of the mechanisms behind sequestration of parasitized erythrocytes would "become increasingly more complicated, with further interactions, receptors, ligands and functional domains". Furthermore, they cautioned that "the challenge will be not to lose ourselves in the molecular detail, but remain focused on the role of [the var genes and other multigene families] in pathogenesis of malaria". We contemplate on these statements, following the recent second Molecular Approaches to Malaria meeting, which was held at the same venue on 2-5 February 2004.
AB - The first Molecular Approaches to Malaria meeting was held 2-5 February 2000 in Lorne, Australia. Following the meeting, Brian Cooke, Mats Wahlgren and Ross Coppel predicted that research into the molecular details of the mechanisms behind sequestration of parasitized erythrocytes would "become increasingly more complicated, with further interactions, receptors, ligands and functional domains". Furthermore, they cautioned that "the challenge will be not to lose ourselves in the molecular detail, but remain focused on the role of [the var genes and other multigene families] in pathogenesis of malaria". We contemplate on these statements, following the recent second Molecular Approaches to Malaria meeting, which was held at the same venue on 2-5 February 2004.
U2 - 10.1016/j.pt.2004.09.002
DO - 10.1016/j.pt.2004.09.002
M3 - Journal article
C2 - 15522665
SN - 1471-4922
VL - 20
SP - 562
EP - 566
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 12
ER -