Variations in 5-HTTLPR: relation to familiar risk of affective disorder, life events, neuroticism and cortisol

Maj Vinberg; Erling Mellerup; Per Kragh Andersen; Bente Bennike; Lars Vedel Kessing

doi:10.1016/j.pnpbp.2009.10.002

Variations in 5-HTTLPR: relation to familiar risk of affective disorder, life events, neuroticism and cortisol

Maj Vinberg, Erling Mellerup, Per Kragh Andersen, Bente Bennike, Lars Vedel Kessing

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

17 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Oct-12

Originalsprog	Engelsk
Tidsskrift	Progress in Neuro-Psychopharmacology & Biological Psychiatry
Vol/bind	34
Udgave nummer	1
Sider (fra-til)	86-91
Antal sider	5
ISSN	0278-5846
DOI	https://doi.org/10.1016/j.pnpbp.2009.10.002
Status	Udgivet - 2009

Bibliografisk note

Adgang til dokumentet

10.1016/j.pnpbp.2009.10.002

Citationsformater

@article{dd4710b0ff6711de825d000ea68e967b,

title = "Variations in 5-HTTLPR: relation to familiar risk of affective disorder, life events, neuroticism and cortisol",

abstract = "BACKGROUND: Variations in the serotonin transporter gene (5-HTTLPR) and stressful life events are associated with affective disorders. AIM: To investigate whether the distribution of the alleles of the 5-HTTLPR is associated with a genetic predisposition to affective disorder and whether these variations interact with life events in relation to depressive symptoms, neuroticism and salivary cortisol. METHOD: In a high-risk population study, healthy monozygotic and dizygotic twins with (high-risk twins) and without (low-risk twins) a co-twin history of affective disorder were identified through nationwide registers. RESULTS: When comparing the 81 individuals homozygote for the long allele with the 125 individuals hetero- and homozygote for the short allele no associations between the allele distribution and a genetic predisposition were found. The presence of the short allele of the 5-HTTLPR and the experience of SLE was associated with a higher neuroticism score, but not with depressive symptoms nor awakening or evening salivary cortisol. CONCLUSION: A combination of variants in 5-HTTLPR and environmental stress seems to increase neuroticism in healthy individuals.",

author = "Maj Vinberg and Erling Mellerup and Andersen, {Per Kragh} and Bente Bennike and Kessing, {Lars Vedel}",

year = "2009",

doi = "10.1016/j.pnpbp.2009.10.002",

language = "English",

volume = "34",

pages = "86--91",

journal = "Progress in Neuro-Psychopharmacology & Biological Psychiatry",

issn = "0278-5846",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Variations in 5-HTTLPR: relation to familiar risk of affective disorder, life events, neuroticism and cortisol

AU - Vinberg, Maj

AU - Mellerup, Erling

AU - Andersen, Per Kragh

AU - Bennike, Bente

AU - Kessing, Lars Vedel

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Variations in the serotonin transporter gene (5-HTTLPR) and stressful life events are associated with affective disorders. AIM: To investigate whether the distribution of the alleles of the 5-HTTLPR is associated with a genetic predisposition to affective disorder and whether these variations interact with life events in relation to depressive symptoms, neuroticism and salivary cortisol. METHOD: In a high-risk population study, healthy monozygotic and dizygotic twins with (high-risk twins) and without (low-risk twins) a co-twin history of affective disorder were identified through nationwide registers. RESULTS: When comparing the 81 individuals homozygote for the long allele with the 125 individuals hetero- and homozygote for the short allele no associations between the allele distribution and a genetic predisposition were found. The presence of the short allele of the 5-HTTLPR and the experience of SLE was associated with a higher neuroticism score, but not with depressive symptoms nor awakening or evening salivary cortisol. CONCLUSION: A combination of variants in 5-HTTLPR and environmental stress seems to increase neuroticism in healthy individuals.

AB - BACKGROUND: Variations in the serotonin transporter gene (5-HTTLPR) and stressful life events are associated with affective disorders. AIM: To investigate whether the distribution of the alleles of the 5-HTTLPR is associated with a genetic predisposition to affective disorder and whether these variations interact with life events in relation to depressive symptoms, neuroticism and salivary cortisol. METHOD: In a high-risk population study, healthy monozygotic and dizygotic twins with (high-risk twins) and without (low-risk twins) a co-twin history of affective disorder were identified through nationwide registers. RESULTS: When comparing the 81 individuals homozygote for the long allele with the 125 individuals hetero- and homozygote for the short allele no associations between the allele distribution and a genetic predisposition were found. The presence of the short allele of the 5-HTTLPR and the experience of SLE was associated with a higher neuroticism score, but not with depressive symptoms nor awakening or evening salivary cortisol. CONCLUSION: A combination of variants in 5-HTTLPR and environmental stress seems to increase neuroticism in healthy individuals.

U2 - 10.1016/j.pnpbp.2009.10.002

DO - 10.1016/j.pnpbp.2009.10.002

M3 - Journal article

C2 - 19822181

SN - 0278-5846

VL - 34

SP - 86

EP - 91

JO - Progress in Neuro-Psychopharmacology & Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology & Biological Psychiatry

IS - 1

ER -