Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Hypertension |
| Vol/bind | 47 |
| Udgave nummer | 1 |
| Sider (fra-til) | 69-73 |
| Antal sider | 4 |
| DOI | |
| Status | Udgivet - 2005 |
Bibliografisk note
Keywords: Adult; Astronauts; Blood Pressure; Cardiac Output; Heart Rate; Humans; Middle Aged; Time Factors; Vascular Resistance; Vasodilation; WeightlessnessAdgang til dokumentet
Citationsformater
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
I: Hypertension, Bind 47, Nr. 1, 2005, s. 69-73.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
}
TY - JOUR
T1 - Vasorelaxation in space.
AU - Norsk, Peter
AU - Damgaard, Morten
AU - Petersen, Lonnie Grove
AU - Gybel, Mikkel
AU - Pump, Bettina
AU - Gabrielsen, Anders
AU - Christensen, Niels Juel
N1 - Keywords: Adult; Astronauts; Blood Pressure; Cardiac Output; Heart Rate; Humans; Middle Aged; Time Factors; Vascular Resistance; Vasodilation; Weightlessness
PY - 2005
Y1 - 2005
N2 - During everyday life, gravity constantly stresses the cardiovascular system in upright humans by diminishing venous return. This decreases cardiac output and induces systemic vasoconstriction to prevent blood pressure from falling. We therefore tested the hypothesis that entering weightlessness leads to a prompt increase in cardiac output and to systemic vasodilatation and that these effects persist for at least a week of weightlessness in space. Cardiac output and mean arterial pressure were measured in 8 healthy humans during acute 20-s periods of weightlessness in parabolic airplane flights and on the seventh and eighth day of weightlessness in 4 astronauts in space. The seated 1-G position acted as reference. Entering weightlessness promptly increased cardiac output by 29+/-7%, from 6.6+/-0.7 to 8.4+/-0.9 L min(-1) (mean+/-SEM; P=0.003), whereas mean arterial pressure and heart rate were unaffected. Thus, systemic vascular resistance decreased by 24+/-4% (P=0.017). After a week of weightlessness in space, cardiac output was increased by 22+/-8% from 5.1+/-0.3 to 6.1+/-0.1 L min(-1) (P=0.021), with mean arterial pressure and heart rate being unchanged so that systemic vascular resistance was decreased by 14+/-9% (P=0.047). In conclusion, entering weightlessness promptly increases cardiac output and dilates the systemic circulation. This vasorelaxation persists for at least a week into spaceflight. Thus, it is probably healthy for the human cardiovascular system to fly in space.
AB - During everyday life, gravity constantly stresses the cardiovascular system in upright humans by diminishing venous return. This decreases cardiac output and induces systemic vasoconstriction to prevent blood pressure from falling. We therefore tested the hypothesis that entering weightlessness leads to a prompt increase in cardiac output and to systemic vasodilatation and that these effects persist for at least a week of weightlessness in space. Cardiac output and mean arterial pressure were measured in 8 healthy humans during acute 20-s periods of weightlessness in parabolic airplane flights and on the seventh and eighth day of weightlessness in 4 astronauts in space. The seated 1-G position acted as reference. Entering weightlessness promptly increased cardiac output by 29+/-7%, from 6.6+/-0.7 to 8.4+/-0.9 L min(-1) (mean+/-SEM; P=0.003), whereas mean arterial pressure and heart rate were unaffected. Thus, systemic vascular resistance decreased by 24+/-4% (P=0.017). After a week of weightlessness in space, cardiac output was increased by 22+/-8% from 5.1+/-0.3 to 6.1+/-0.1 L min(-1) (P=0.021), with mean arterial pressure and heart rate being unchanged so that systemic vascular resistance was decreased by 14+/-9% (P=0.047). In conclusion, entering weightlessness promptly increases cardiac output and dilates the systemic circulation. This vasorelaxation persists for at least a week into spaceflight. Thus, it is probably healthy for the human cardiovascular system to fly in space.
U2 - 10.1161/01.HYP.0000194332.98674.57
DO - 10.1161/01.HYP.0000194332.98674.57
M3 - Journal article
C2 - 16301338
SN - 1524-4563
VL - 47
SP - 69
EP - 73
JO - Hypertension
JF - Hypertension
IS - 1
ER -