Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR)

Keld Danoe,; Francesco Blasi; Louring Roldan, Ann; Vittoria Cubellis, Maria; Teresa Masucci, Maria; Ettore Appella,; Wolf-Dieter Schleuning,; Niels Behrendt,; Ebbe Rønne; Peter Kristensen,; Jari Pollanen,; Eeva-Marjatta Salonen,; W Stephens, Ross; Hannele Tapiovaara,; Antti Vaheri,; Birk Moeller, Lisbeth; Vincent Ellis,; Roege Lund, Leif; Michael Ploug,; Charles Pyke; Laszlo Patthy

Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR)

Keld Danoe, (Opfinder), Francesco Blasi (Opfinder), Louring Roldan, Ann (Opfinder), Vittoria Cubellis, Maria (Opfinder), Teresa Masucci, Maria (Opfinder), Ettore Appella, (Opfinder), Wolf-Dieter Schleuning, (Opfinder), Niels Behrendt, (Opfinder), Ebbe Rønne (Opfinder), Peter Kristensen, (Opfinder), Jari Pollanen, (Opfinder), Eeva-Marjatta Salonen, (Opfinder), W Stephens, Ross (Opfinder), Hannele Tapiovaara, (Opfinder), Antti Vaheri, (Opfinder), Birk Moeller, Lisbeth (Opfinder), Vincent Ellis, (Opfinder), Roege Lund, Leif (Opfinder), Michael Ploug, (Opfinder), Charles Pyke (Opfinder)Laszlo Patthy (Opfinder)

Ph.d.-studienævnet for Medicin

Publikation: Patent

Abstract

Activation of plasminogen to plasma is inhibited by preventing the binding of a receptor binding form of urokinase-type plasminogen activator to a urokinase-type plasminogen activator receptor in a mammal, thereby preventing the urokinase-type plasminogen activator from converting plasminogen into plasmin. DNA fragments which encode for soluble, active fragments of the urokinase-type plasminogen activator are provided.

Originalsprog	Engelsk
IPC	A61K 38/ 00 A N
Patentnummer	US5891664
Land/Område	Danmark
Prioritetsdato	06/10/1994
Prioritetsnummer	US19940319052
Status	Udgivet - 6 apr. 1999

Citationsformater

Danoe, K., Blasi, F., Roldan, Ann, L., Cubellis, Maria, V., Masucci, Maria, T., Appella, E., Schleuning, W.-D., Behrendt, N., Rønne, E., Kristensen, P., Pollanen, J., Salonen, E.-M., Stephens, Ross, W., Tapiovaara, H., Vaheri, A., Moeller, Lisbeth, B., Ellis, V., Lund, Leif, R., Ploug, M., ... Patthy, L. (1999). Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR). (Patentnummer US5891664).

Danoe, K, Blasi, F, Roldan, Ann, L, Cubellis, Maria, V, Masucci, Maria, T, Appella, E, Schleuning, W-D, Behrendt, N, Rønne, E, Kristensen, P, Pollanen, J, Salonen, E-M, Stephens, Ross, W, Tapiovaara, H, Vaheri, A, Moeller, Lisbeth, B, Ellis, V, Lund, Leif, R, Ploug, M, Pyke, C & Patthy, L apr.. 06 1999, Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR), Patentnummer US5891664.

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title = "Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR)",

abstract = "Activation of plasminogen to plasma is inhibited by preventing the binding of a receptor binding form of urokinase-type plasminogen activator to a urokinase-type plasminogen activator receptor in a mammal, thereby preventing the urokinase-type plasminogen activator from converting plasminogen into plasmin. DNA fragments which encode for soluble, active fragments of the urokinase-type plasminogen activator are provided.",

author = "Keld Danoe, and Francesco Blasi and {Roldan, Ann}, Louring and {Cubellis, Maria}, Vittoria and {Masucci, Maria}, Teresa and Ettore Appella, and Wolf-Dieter Schleuning, and Niels Behrendt, and Ebbe R{\o}nne and Peter Kristensen, and Jari Pollanen, and Eeva-Marjatta Salonen, and {Stephens, Ross}, W and Hannele Tapiovaara, and Antti Vaheri, and {Moeller, Lisbeth}, Birk and Vincent Ellis, and {Lund, Leif}, Roege and Michael Ploug, and Charles Pyke and Laszlo Patthy",

year = "1999",

month = apr,

day = "6",

language = "English",

type = "Patent",

note = "US5891664; A61K 38/ 00 A N",

}

TY - PAT

T1 - Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR)

AU - Danoe,, Keld

AU - Blasi, Francesco

AU - Roldan, Ann, Louring

AU - Cubellis, Maria, Vittoria

AU - Masucci, Maria, Teresa

AU - Appella,, Ettore

AU - Schleuning,, Wolf-Dieter

AU - Behrendt,, Niels

AU - Rønne, Ebbe

AU - Kristensen,, Peter

AU - Pollanen,, Jari

AU - Salonen,, Eeva-Marjatta

AU - Stephens, Ross, W

AU - Tapiovaara,, Hannele

AU - Vaheri,, Antti

AU - Moeller, Lisbeth, Birk

AU - Ellis,, Vincent

AU - Lund, Leif, Roege

AU - Ploug,, Michael

AU - Pyke, Charles

AU - Patthy, Laszlo

PY - 1999/4/6

Y1 - 1999/4/6

N2 - Activation of plasminogen to plasma is inhibited by preventing the binding of a receptor binding form of urokinase-type plasminogen activator to a urokinase-type plasminogen activator receptor in a mammal, thereby preventing the urokinase-type plasminogen activator from converting plasminogen into plasmin. DNA fragments which encode for soluble, active fragments of the urokinase-type plasminogen activator are provided.

AB - Activation of plasminogen to plasma is inhibited by preventing the binding of a receptor binding form of urokinase-type plasminogen activator to a urokinase-type plasminogen activator receptor in a mammal, thereby preventing the urokinase-type plasminogen activator from converting plasminogen into plasmin. DNA fragments which encode for soluble, active fragments of the urokinase-type plasminogen activator are provided.

M3 - Patent

M1 - US5891664

ER -