TY - JOUR
T1 - VEGF-D is expressed in activated lymphoid cells and in tumors of hematopoietic and lymphoid tissues.
AU - Bardelli, Monia
AU - Leucci, Eleonora
AU - Schürfeld, Karin
AU - Bellan, Cristiana
AU - Passiatore, Giovanni
AU - Rocchigiani, Marina
AU - Bartolommei, Sabrina
AU - Orlandini, Maurizio
AU - Zagursky, Jennifer
AU - Lazzi, Stefano
AU - De Falco, Giulia
AU - Tosi, Piero
AU - Oliviero, Salvatore
AU - Leoncini, Lorenzo
N1 - Keywords: Antibodies, Monoclonal; Biopsy; Bone Marrow Cells; Cell Line, Tumor; Gene Expression Regulation, Leukemic; Gene Expression Regulation, Neoplastic; HL-60 Cells; Hematopoietic Stem Cells; Humans; K562 Cells; Lymph Nodes; Lymphocytes; Vascular Endothelial Growth Factor D; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factor Receptor-3
PY - 2007
Y1 - 2007
N2 - Vascular Endothelial Growth Factor (VEGF)-D is a member of the VEGF family of angiogenic growth factors that activate the Vascular Endothelial Growth Factor Receptor (VEGFR)-2 and VEGFR-3, which are mainly expressed in blood and lymphatic vessels. Here we have analyzed by using monoclonal antibodies, the expression of VEGF-D and its cognate receptor VEGFR-3 in normal and pathologic bone marrow and lymph node biopsies. This analysis revealed that VEGF-D is expressed in B cells of the germinal centers, scattered B and T blasts, myeloid progenitors, acute leukemia, several types of non Hodgkin lymphoma, and classical Hodgkin's lymphoma. In normal tissues VEGFR-3 was only expressed in fenestrated capillaries of bone marrow and in lymphatic vessels of lymph nodes, while in VEGF-D expressing tumors newly formed vessels, but not malignant cells, showed high VEGFR-3 expression. These data suggest that VEGF-D could contribute to leukemia and lymphoma growth via the induction of angiogenesis in bone marrow and lymphoid tissues.
AB - Vascular Endothelial Growth Factor (VEGF)-D is a member of the VEGF family of angiogenic growth factors that activate the Vascular Endothelial Growth Factor Receptor (VEGFR)-2 and VEGFR-3, which are mainly expressed in blood and lymphatic vessels. Here we have analyzed by using monoclonal antibodies, the expression of VEGF-D and its cognate receptor VEGFR-3 in normal and pathologic bone marrow and lymph node biopsies. This analysis revealed that VEGF-D is expressed in B cells of the germinal centers, scattered B and T blasts, myeloid progenitors, acute leukemia, several types of non Hodgkin lymphoma, and classical Hodgkin's lymphoma. In normal tissues VEGFR-3 was only expressed in fenestrated capillaries of bone marrow and in lymphatic vessels of lymph nodes, while in VEGF-D expressing tumors newly formed vessels, but not malignant cells, showed high VEGFR-3 expression. These data suggest that VEGF-D could contribute to leukemia and lymphoma growth via the induction of angiogenesis in bone marrow and lymphoid tissues.
U2 - 10.1080/10428190701540975
DO - 10.1080/10428190701540975
M3 - Journal article
C2 - 17917969
SN - 1042-8194
VL - 48
SP - 2014
EP - 2021
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 10
ER -