Virus-specific antibody indices may supplement the total IgG index in diagnostics of multiple sclerosis

C. Kyllesbech; N. Trier; R. Slibinskas; E. Ciplys; A. Tsakiri; J. L. Frederiksen; G. Houen

doi:10.1016/j.jneuroim.2022.577868

Virus-specific antibody indices may supplement the total IgG index in diagnostics of multiple sclerosis

C. Kyllesbech, N. Trier, R. Slibinskas, E. Ciplys, A. Tsakiri, J. L. Frederiksen, G. Houen^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

6 Citationer (Scopus)

Abstract

Intrathecal antibody synthesis to viruses is associated with multiple sclerosis (MS). Here, IgG levels to Epstein-Barr virus (EBV) BamHI-A rightward frame 1 (BARF1), EBV nuclear antigen 1 (EBNA1), mumps virus (MuV) nucleoprotein (NuP), measles virus (MeV) NuP and rubella virus (RuV) capsid protein (CaP) were found to be elevated in serum and cerebrospinal fluid (CSF) of MS patients compared to healthy controls (HCs), whereas the opposite was found for cytomegalovirus (CMV) pp52. Strong correlations between serum and CSF IgG were seen for MeV, CMV and RuV in both MS patients and HCs. The antigen panel obtained high sensitivity (81%) and specificity (86%), demonstrating that antigen panels may supplement the total IgG index used in MS diagnosis.

Originalsprog	Engelsk
Artikelnummer	577868
Tidsskrift	Journal of Neuroimmunology
Vol/bind	367
Antal sider	9
ISSN	0165-5728
DOI	https://doi.org/10.1016/j.jneuroim.2022.577868
Status	Udgivet - 2022
Udgivet eksternt	Ja

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10.1016/j.jneuroim.2022.577868

FulltextForlagets udgivne version, 1,94 MB

Citationsformater

@article{9e82e2d2504847fd9685c43b520055f1,

title = "Virus-specific antibody indices may supplement the total IgG index in diagnostics of multiple sclerosis",

abstract = "Intrathecal antibody synthesis to viruses is associated with multiple sclerosis (MS). Here, IgG levels to EpsteinBarr virus (EBV) BamHI-A rightward frame 1 (BARF1), EBV nuclear antigen 1 (EBNA1), mumps virus (MuV) nucleoprotein (NuP), measles virus (MeV) NuP and rubella virus (RuV) capsid protein (CaP) were found to be elevated in serum and cerebrospinal fluid (CSF) of MS patients compared to healthy controls (HCs), whereas the opposite was found for cytomegalovirus (CMV) pp52. Strong correlations between serum and CSF IgG were seen for MeV, CMV and RuV in both MS patients and HCs. The antigen panel obtained high sensitivity (81%) and specificity (86%), demonstrating that antigen panels may supplement the total IgG index used in MS diagnosis.",

keywords = "Antibody index, Antigen, Cerebrospinal fluid, Multiple sclerosis, Oligoclonal bands, Serum, Virus, EPSTEIN-BARR-VIRUS, IMMUNE-RESPONSE, MRZ REACTION, INFECTION, MARKER",

author = "C. Kyllesbech and N. Trier and R. Slibinskas and E. Ciplys and A. Tsakiri and Frederiksen, {J. L.} and G. Houen",

year = "2022",

doi = "10.1016/j.jneuroim.2022.577868",

language = "English",

volume = "367",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

}

TY - JOUR

T1 - Virus-specific antibody indices may supplement the total IgG index in diagnostics of multiple sclerosis

AU - Kyllesbech, C.

AU - Trier, N.

AU - Slibinskas, R.

AU - Ciplys, E.

AU - Tsakiri, A.

AU - Frederiksen, J. L.

AU - Houen, G.

PY - 2022

Y1 - 2022

N2 - Intrathecal antibody synthesis to viruses is associated with multiple sclerosis (MS). Here, IgG levels to EpsteinBarr virus (EBV) BamHI-A rightward frame 1 (BARF1), EBV nuclear antigen 1 (EBNA1), mumps virus (MuV) nucleoprotein (NuP), measles virus (MeV) NuP and rubella virus (RuV) capsid protein (CaP) were found to be elevated in serum and cerebrospinal fluid (CSF) of MS patients compared to healthy controls (HCs), whereas the opposite was found for cytomegalovirus (CMV) pp52. Strong correlations between serum and CSF IgG were seen for MeV, CMV and RuV in both MS patients and HCs. The antigen panel obtained high sensitivity (81%) and specificity (86%), demonstrating that antigen panels may supplement the total IgG index used in MS diagnosis.

AB - Intrathecal antibody synthesis to viruses is associated with multiple sclerosis (MS). Here, IgG levels to EpsteinBarr virus (EBV) BamHI-A rightward frame 1 (BARF1), EBV nuclear antigen 1 (EBNA1), mumps virus (MuV) nucleoprotein (NuP), measles virus (MeV) NuP and rubella virus (RuV) capsid protein (CaP) were found to be elevated in serum and cerebrospinal fluid (CSF) of MS patients compared to healthy controls (HCs), whereas the opposite was found for cytomegalovirus (CMV) pp52. Strong correlations between serum and CSF IgG were seen for MeV, CMV and RuV in both MS patients and HCs. The antigen panel obtained high sensitivity (81%) and specificity (86%), demonstrating that antigen panels may supplement the total IgG index used in MS diagnosis.

KW - Antibody index

KW - Antigen

KW - Cerebrospinal fluid

KW - Multiple sclerosis

KW - Oligoclonal bands

KW - Serum

KW - Virus

KW - EPSTEIN-BARR-VIRUS

KW - IMMUNE-RESPONSE

KW - MRZ REACTION

KW - INFECTION

KW - MARKER

U2 - 10.1016/j.jneuroim.2022.577868

DO - 10.1016/j.jneuroim.2022.577868

M3 - Journal article

C2 - 35477126

SN - 0165-5728

VL - 367

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

M1 - 577868

ER -