Vitamin D Concentrations at Birth and the Risk of Rheumatoid Arthritis in Early Adulthood: A Danish Population-Based Case-Cohort Study

Isabel Cardoso, Ina Olmer Specht*, Fanney Thorsteinsdottir, Marta Jadwiga Thorbek, Amélie Keller, Maria Stougaard, Arieh S. Cohen, Mina Nicole Händel, Lars Erik Kristensen, Berit Lilienthal Heitmann

*Corresponding author af dette arbejde

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Abstract

Background: Low vitamin D in pregnancy may impair the development of the fetal immune system and influence the risk of later development of rheumatoid arthritis (RA) in the offspring. The aim was to examine whether lower 25-hydroxyvitamin D3 (25(OH)D) concentrations at birth were associated with the risk of developing RA in early adulthood. Methods: This case-cohort study obtained data from Danish registers and biobanks. Cases included all individuals born during 1981–1996 and recorded in the Danish National Patient Register with a diagnosis of RA with age >18 years at first admission. The random comparison consisted of a subset of Danish children. Vitamin D concentrations were measured in newborn dried blood. In total, 805 RA cases and 2416 individuals from the subcohort were included in the final analysis. Weighted Cox regression was used to calculate hazard ratio (HR). Results: The median (interquartile rage (IQR)) 25(OH)D concentrations among cases were 24.9 nmol/L (IQR:15.4;36.9) and 23.9 nmol/L (IQR:13.6;36.4) among the subcohort. There was no indication of a lower risk of RA among individuals in the highest vitamin D quintile compared with the lowest (HRadj.:1.21 (0.90;1.63)). Conclusion: The risk of RA in early adulthood was not associated with vitamin D concentrations at birth.

OriginalsprogEngelsk
Artikelnummer447
TidsskriftNutrients
Vol/bind14
Udgave nummer3
Antal sider11
ISSN2072-6643
DOI
StatusUdgivet - 2022

Bibliografisk note

Funding Information:
This research was funded by grants from The Danish Rheumatism Association (Gigt-foreningen), Gangstedfonden, Dagmar Marshalls Fond, and Kong Christian den Tiendes Fond, and the Programme Commission on Health, Food and Welfare under the Danish Council for Strategic research (Grant number 0603-00453B). We are further grateful to the Oak Foundation for the essential co-financing of the Parker Institute (Grant number OCAY-18-774-OFIL).

Funding Information:
Funding: This research was funded by grants from The Danish Rheumatism Association (Gigt-foreningen), Gangstedfonden, Dagmar Marshalls Fond, and Kong Christian den Tiendes Fond, and the Programme Commission on Health, Food and Welfare under the Danish Council for Strategic research (Grant number 0603-00453B). We are further grateful to the Oak Foundation for the essential co-financing of the Parker Institute (Grant number OCAY-18-774-OFIL).

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

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