Watch Out for Those Terrible Twos! Dinucleotide Accumulation Dysregulates Mitochondrial Transcription

Melvin Noe Gonzalez; Jesper Q Svejstrup

doi:10.1016/j.molcel.2019.11.002

Watch Out for Those Terrible Twos! Dinucleotide Accumulation Dysregulates Mitochondrial Transcription

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Rådgivning

Abstract

In this issue of Molecular Cell, Nicholls et al. (2019) show that the oligoribonuclease REXO2 degrades mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome, shedding new light on the importance of complete RNA degradation for transcriptional integrity.

Originalsprog	Engelsk
Tidsskrift	Molecular Cell
Vol/bind	76
Udgave nummer	5
Sider (fra-til)	696-698
Antal sider	3
ISSN	1097-2765
DOI	https://doi.org/10.1016/j.molcel.2019.11.002
Status	Udgivet - 5 dec. 2019
Udgivet eksternt	Ja

Bibliografisk note

Adgang til dokumentet

10.1016/j.molcel.2019.11.002Licens: Ikke-specificeret

Citationsformater

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abstract = "In this issue of Molecular Cell, Nicholls et al. (2019) show that the oligoribonuclease REXO2 degrades mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome, shedding new light on the importance of complete RNA degradation for transcriptional integrity.",

keywords = "Animals, Mitochondria, Mitophagy, Promoter Regions, Genetic, RNA, Transcription, Genetic",

author = "{Noe Gonzalez}, Melvin and Svejstrup, {Jesper Q}",

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AB - In this issue of Molecular Cell, Nicholls et al. (2019) show that the oligoribonuclease REXO2 degrades mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome, shedding new light on the importance of complete RNA degradation for transcriptional integrity.

KW - Animals

KW - Mitochondria

KW - Mitophagy

KW - Promoter Regions, Genetic

KW - RNA

KW - Transcription, Genetic

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DO - 10.1016/j.molcel.2019.11.002

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