Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021

Karen Leth Nielsen; Marc Sørensen; Frederik Boëtius Hertz; Maria Anna Misiakou; Henrik Hasman; Susanne Häussler; Marie Helleberg; Kristian Schønning

doi:10.2807/1560-7917.ES.2023.28.17.2300196

Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021

Karen Leth Nielsen, Marc Sørensen, Frederik Boëtius Hertz, Maria Anna Misiakou, Henrik Hasman, Susanne Häussler, Marie Helleberg, Kristian Schønning

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

2 Citationer (Scopus)

16 Downloads (Pure)

Abstract

A hypervirulent Klebsiella pneumoniae SL218 (ST23-KL57), phylogenetically distinct from the classical hypervirulent SL23 (ST23-KL1) lineage, was transmitted between hospitalised patients in Denmark in 2021. The isolate carried a hybrid resistance and virulence plasmid containing blaNDM-1 and a plasmid containing blaOXA-48 (pOXA-48); the latter plasmid was horizontally transferred within-patient to Serratia marcescens. The convergence of drug resistance and virulence factors in single plasmids and in different lineages of K. pneumoniae is concerning and requires surveillance.

Originalsprog	Engelsk
Tidsskrift	Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
Vol/bind	28
Udgave nummer	17
Antal sider	7
ISSN	1025-496X
DOI	https://doi.org/10.2807/1560-7917.ES.2023.28.17.2300196
Status	Udgivet - 2023

Adgang til dokumentet

10.2807/1560-7917.ES.2023.28.17.2300196Licens: CC BY

FulltextForlagets udgivne version, 402 KBLicens: CC BY

Citationsformater

Nielsen, K. L., Sørensen, M., Hertz, F. B., Misiakou, M. A., Hasman, H., Häussler, S., Helleberg, M., & Schønning, K. (2023). Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 28(17). https://doi.org/10.2807/1560-7917.ES.2023.28.17.2300196

Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021. / Nielsen, Karen Leth; Sørensen, Marc ; Hertz, Frederik Boëtius; Misiakou, Maria Anna; Hasman, Henrik; Häussler, Susanne; Helleberg, Marie ; Schønning, Kristian.

I: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, Bind 28, Nr. 17, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Nielsen, KL, Sørensen, M , Hertz, FB, Misiakou, MA, Hasman, H, Häussler, S, Helleberg, M & Schønning, K 2023, 'Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021', Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, bind 28, nr. 17. https://doi.org/10.2807/1560-7917.ES.2023.28.17.2300196

Nielsen KL, Sørensen M , Hertz FB, Misiakou MA, Hasman H, Häussler S et al. Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 2023;28(17). https://doi.org/10.2807/1560-7917.ES.2023.28.17.2300196

Nielsen, Karen Leth ; Sørensen, Marc ; Hertz, Frederik Boëtius ; Misiakou, Maria Anna ; Hasman, Henrik ; Häussler, Susanne ; Helleberg, Marie ; Schønning, Kristian. / Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021. I: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 2023 ; Bind 28, Nr. 17.

@article{0424bb7d56f8401ba4c289cf1889c744,

title = "Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021",

abstract = "A hypervirulent Klebsiella pneumoniae SL218 (ST23-KL57), phylogenetically distinct from the classical hypervirulent SL23 (ST23-KL1) lineage, was transmitted between hospitalised patients in Denmark in 2021. The isolate carried a hybrid resistance and virulence plasmid containing blaNDM-1 and a plasmid containing blaOXA-48 (pOXA-48); the latter plasmid was horizontally transferred within-patient to Serratia marcescens. The convergence of drug resistance and virulence factors in single plasmids and in different lineages of K. pneumoniae is concerning and requires surveillance.",

keywords = "antimicrobial resistance, Hospital-acquired infections, hypervirulent K. pneumoniae, OXA-48, within-patient plasmid transfer",

author = "Nielsen, {Karen Leth} and Marc S{\o}rensen and Hertz, {Frederik Bo{\"e}tius} and Misiakou, {Maria Anna} and Henrik Hasman and Susanne H{\"a}ussler and Marie Helleberg and Kristian Sch{\o}nning",

year = "2023",

doi = "10.2807/1560-7917.ES.2023.28.17.2300196",

language = "English",

volume = "28",

journal = "Eurosurveillance",

issn = "1025-496X",

publisher = "Centre Europeen pour la Surveillance Epidemiologique du SIDA",

number = "17",

}

TY - JOUR

T1 - Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021

AU - Nielsen, Karen Leth

AU - Sørensen, Marc

AU - Hertz, Frederik Boëtius

AU - Misiakou, Maria Anna

AU - Hasman, Henrik

AU - Häussler, Susanne

AU - Helleberg, Marie

AU - Schønning, Kristian

PY - 2023

Y1 - 2023

N2 - A hypervirulent Klebsiella pneumoniae SL218 (ST23-KL57), phylogenetically distinct from the classical hypervirulent SL23 (ST23-KL1) lineage, was transmitted between hospitalised patients in Denmark in 2021. The isolate carried a hybrid resistance and virulence plasmid containing blaNDM-1 and a plasmid containing blaOXA-48 (pOXA-48); the latter plasmid was horizontally transferred within-patient to Serratia marcescens. The convergence of drug resistance and virulence factors in single plasmids and in different lineages of K. pneumoniae is concerning and requires surveillance.

AB - A hypervirulent Klebsiella pneumoniae SL218 (ST23-KL57), phylogenetically distinct from the classical hypervirulent SL23 (ST23-KL1) lineage, was transmitted between hospitalised patients in Denmark in 2021. The isolate carried a hybrid resistance and virulence plasmid containing blaNDM-1 and a plasmid containing blaOXA-48 (pOXA-48); the latter plasmid was horizontally transferred within-patient to Serratia marcescens. The convergence of drug resistance and virulence factors in single plasmids and in different lineages of K. pneumoniae is concerning and requires surveillance.

KW - antimicrobial resistance

KW - Hospital-acquired infections

KW - hypervirulent K. pneumoniae

KW - OXA-48

KW - within-patient plasmid transfer

U2 - 10.2807/1560-7917.ES.2023.28.17.2300196

DO - 10.2807/1560-7917.ES.2023.28.17.2300196

M3 - Journal article

C2 - 37103784

AN - SCOPUS:85159241948

VL - 28

JO - Eurosurveillance

JF - Eurosurveillance

SN - 1025-496X

IS - 17

ER -