Witnessed sleep apneas together with elevated plasma glucose are predictors of COPD exacerbations

Truls S. Ingebrigtsen; Jacob L. Marott; Peter Lange

doi:10.1080/20018525.2020.1765543

Witnessed sleep apneas together with elevated plasma glucose are predictors of COPD exacerbations

Truls S. Ingebrigtsen, Jacob L. Marott, Peter Lange^*

^*Corresponding author af dette arbejde

Afdeling for Epidemiologi

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

1 Citationer (Scopus)

14 Downloads (Pure)

Abstract

Objective

Sleep apnea and elevated plasma glucose associates with inflammation which associates with the risk of COPD exacerbations. We investigated the risk of exacerbations in individuals with COPD, witnessed sleep apneas, and elevated plasma glucose.

Methods

From the Copenhagen City Heart Study cohort, we identified 564 individuals with COPD (forced expiratory volume in 1 sec divided by forced vital capacity, FEV1/FVC

Results

We identified 74 (13%) individuals with sleep apnea without elevated plasma glucose, 70 (12%) had elevated plasma glucose (above 6.9 mM (>125 mg/dL)) without sleep apnea and 11 individuals had the presence of both conditions. In univariable analysis, witnessed apneas together with elevated plasma glucose had a high risk of exacerbations, hazard ratio (HR) = 5.81 (2.34-14.4, p = 0.0001) compared to those without sleep apnea and without elevated plasma glucose. Multivariable analysis, adjusting for several risk factors of exacerbations, showed a similar result, HR = 3.45 (1.13-10.5, p = 0.03). Both presence of sleep apnea without elevated plasma glucose and the presence of elevated plasma glucose without sleep apnea showed no associations with the risk of exacerbations.

Conclusions

Witnessed sleep apneas in COPD are associated with increased risk of exacerbations, but only among those with elevated plasma glucose.

Originalsprog	Engelsk
Artikelnummer	1765543
Tidsskrift	European Clinical Respiratory Journal
Vol/bind	7
Udgave nummer	1
Antal sider	8
ISSN	2001-8525
DOI	https://doi.org/10.1080/20018525.2020.1765543
Status	Udgivet - 2020

Adgang til dokumentet

10.1080/20018525.2020.1765543Licens: CC BY

Witnessed sleep apneas together with elevated plasma glucose are predictors of COPD exacerbationsForlagets udgivne version, 1,16 MBLicens: CC BY

Citationsformater

@article{dd748e385a2d41cb80e8db7a84abdcfb,

title = "Witnessed sleep apneas together with elevated plasma glucose are predictors of COPD exacerbations",

abstract = "ObjectiveSleep apnea and elevated plasma glucose associates with inflammation which associates with the risk of COPD exacerbations. We investigated the risk of exacerbations in individuals with COPD, witnessed sleep apneas, and elevated plasma glucose.MethodsFrom the Copenhagen City Heart Study cohort, we identified 564 individuals with COPD (forced expiratory volume in 1 sec divided by forced vital capacity, FEV1/FVCResultsWe identified 74 (13%) individuals with sleep apnea without elevated plasma glucose, 70 (12%) had elevated plasma glucose (above 6.9 mM (>125 mg/dL)) without sleep apnea and 11 individuals had the presence of both conditions. In univariable analysis, witnessed apneas together with elevated plasma glucose had a high risk of exacerbations, hazard ratio (HR) = 5.81 (2.34-14.4, p = 0.0001) compared to those without sleep apnea and without elevated plasma glucose. Multivariable analysis, adjusting for several risk factors of exacerbations, showed a similar result, HR = 3.45 (1.13-10.5, p = 0.03). Both presence of sleep apnea without elevated plasma glucose and the presence of elevated plasma glucose without sleep apnea showed no associations with the risk of exacerbations.ConclusionsWitnessed sleep apneas in COPD are associated with increased risk of exacerbations, but only among those with elevated plasma glucose.",

keywords = "Sleep apnea, glucose, COPD, severe exacerbations, OBSTRUCTIVE PULMONARY-DISEASE, METABOLIC SYNDROME, HYPERGLYCEMIA, INFLAMMATION, OUTCOMES, HEALTH, DYSFUNCTION, PREVALENCE, BIOMARKERS, OVERWEIGHT",

author = "Ingebrigtsen, {Truls S.} and Marott, {Jacob L.} and Peter Lange",

year = "2020",

doi = "10.1080/20018525.2020.1765543",

language = "English",

volume = "7",

journal = "European Clinical Respiratory Journal",

issn = "2001-8525",

publisher = "Co-Action Publishing",

number = "1",

}

TY - JOUR

T1 - Witnessed sleep apneas together with elevated plasma glucose are predictors of COPD exacerbations

AU - Ingebrigtsen, Truls S.

AU - Marott, Jacob L.

AU - Lange, Peter

PY - 2020

Y1 - 2020

N2 - ObjectiveSleep apnea and elevated plasma glucose associates with inflammation which associates with the risk of COPD exacerbations. We investigated the risk of exacerbations in individuals with COPD, witnessed sleep apneas, and elevated plasma glucose.MethodsFrom the Copenhagen City Heart Study cohort, we identified 564 individuals with COPD (forced expiratory volume in 1 sec divided by forced vital capacity, FEV1/FVCResultsWe identified 74 (13%) individuals with sleep apnea without elevated plasma glucose, 70 (12%) had elevated plasma glucose (above 6.9 mM (>125 mg/dL)) without sleep apnea and 11 individuals had the presence of both conditions. In univariable analysis, witnessed apneas together with elevated plasma glucose had a high risk of exacerbations, hazard ratio (HR) = 5.81 (2.34-14.4, p = 0.0001) compared to those without sleep apnea and without elevated plasma glucose. Multivariable analysis, adjusting for several risk factors of exacerbations, showed a similar result, HR = 3.45 (1.13-10.5, p = 0.03). Both presence of sleep apnea without elevated plasma glucose and the presence of elevated plasma glucose without sleep apnea showed no associations with the risk of exacerbations.ConclusionsWitnessed sleep apneas in COPD are associated with increased risk of exacerbations, but only among those with elevated plasma glucose.

AB - ObjectiveSleep apnea and elevated plasma glucose associates with inflammation which associates with the risk of COPD exacerbations. We investigated the risk of exacerbations in individuals with COPD, witnessed sleep apneas, and elevated plasma glucose.MethodsFrom the Copenhagen City Heart Study cohort, we identified 564 individuals with COPD (forced expiratory volume in 1 sec divided by forced vital capacity, FEV1/FVCResultsWe identified 74 (13%) individuals with sleep apnea without elevated plasma glucose, 70 (12%) had elevated plasma glucose (above 6.9 mM (>125 mg/dL)) without sleep apnea and 11 individuals had the presence of both conditions. In univariable analysis, witnessed apneas together with elevated plasma glucose had a high risk of exacerbations, hazard ratio (HR) = 5.81 (2.34-14.4, p = 0.0001) compared to those without sleep apnea and without elevated plasma glucose. Multivariable analysis, adjusting for several risk factors of exacerbations, showed a similar result, HR = 3.45 (1.13-10.5, p = 0.03). Both presence of sleep apnea without elevated plasma glucose and the presence of elevated plasma glucose without sleep apnea showed no associations with the risk of exacerbations.ConclusionsWitnessed sleep apneas in COPD are associated with increased risk of exacerbations, but only among those with elevated plasma glucose.

KW - Sleep apnea

KW - glucose

KW - COPD

KW - severe exacerbations

KW - OBSTRUCTIVE PULMONARY-DISEASE

KW - METABOLIC SYNDROME

KW - HYPERGLYCEMIA

KW - INFLAMMATION

KW - OUTCOMES

KW - HEALTH

KW - DYSFUNCTION

KW - PREVALENCE

KW - BIOMARKERS

KW - OVERWEIGHT

U2 - 10.1080/20018525.2020.1765543

DO - 10.1080/20018525.2020.1765543

M3 - Journal article

C2 - 33224452

VL - 7

JO - European Clinical Respiratory Journal

JF - European Clinical Respiratory Journal

SN - 2001-8525

IS - 1

M1 - 1765543

ER -